Clinical study of senile retinoschisis.
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Biomedical subjects
Publications and source records attributed to N E Byer.
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Lattice degeneration of the retina is the most important of all clinically distinct entities that effect the peripheral fundus and are related to retinal detachment. The purpose of this review is to survey the extensive literature, to evaluate the many diverse opinions on this subject, and to correlate and summarize all the known facts regarding this disease entity. The disease is fully defined and described, both clinically and histologically. Some aspects of the disease are still poorly understood, and some remain controversial, especially in the area of management. For this reason, the indications for treatment are discussed under eight subsections, with a view toward providing practical guidelines for recommendations in management.
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Explore the source record for details and available documents.
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The natural history of senile retionoschisis was studied by observing a series of 193 eyes of 108 nonreferred patients who had no history of significant ocular disease, while refraining from the use of any form of prophylactic intervention, for follow-up periods ranging from 2 to 11 years. One patient at the outset of the study had double layer holes, which had already led to a localized subclinical retinal detachment that had been left untreated, and did not progress during observation for more than two years. One patient developed a small asymptomatic nonprogressive retinal detachment from an outer layer hole. Four eyes showed posterior extension, but in only one was this serious. Nine eyes developed new retinal breaks, one in both layers, but none progressed in extent of retinoschisis or to retinal detachment. Of particular interest were seven eyes which showed unmistakable regression, the retinoschisis disappearing completely in six eyes. Based on reported cases, an estimated computation is made which places the probable risk of frank, progressive, symptomatic retinal detachment resulting from retinoschisis at about 0.07%. Four indications for treatment are given which are considered justified at the present state of our knowledge.