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Biomedical subjects

N E Chernekhovskaia

Publications and source records attributed to N E Chernekhovskaia.

At least 19 recordsLinked to original sources
PubMed2005

[Potential of antiinflammatory therapy in patients with chronic obstructive lung disease].

The aim of the study was to investigate the effects of erespal (fenspirid) on the clinical manifestations and parameters of inflammation in patients with chronic obstructive lung disease (COLD). The two stages of the study included 3-weak treatment during exacerbation periods and a 3-month outpatient follow-up during clinical remission periods. Erespal was administered twice a day in a total dose of 160 mg/day. The study included evaluation of clinical symptoms, respiratory function, bronchoscopic data, laboratory indices of inflammation, antioxydative status, life quality (LQ), as well as cytological and cytochemical analysis of induced sputum (IS). During exacerbation periods of COLD the researchers observed early and noticeable antitussive and mucolytic action of erespal, which were associated with lessening of bronchial obstruction and inflammation, significant fall of C-reactive protein level, cytosis in IS, proportion of neutrophiles (p < 0.01), elevation of lysosomal cation proteins in neutrophiles (p < 0.01), increase of total oxidant serum level (in 46.2% of the patients vs. 26.3% of the patients in the conventional therapy group). Long term (3 months) treatment with erespal led to further positive dynamics of clinical and laboratory indices of inflammation, and improved the results of cytological and cytochemical study of IS. The results of the study demonstrate that inclusion of erespal in complex therapy of COLD increases efficacy of treatment, due to its anti-inflammatory action during the periods of exacerbation and relative remission, prevents augmenting of bronchial obstruction, and improves patients' LQ.

Adult↗
PubMed2003

[The stomach and duodenum condition in patients with chronic obstructive lung diseases].

Examining the gastroduodenal mucosa (GDM) in 61 patients with chronic obstructive pulmonary diseases (COPD) showed changes in the areas studied in all cases. GDM atrophy increased with the severity of COPD. Helicobacter pylori are essential in developing gastric pathology in patients with mild bronchopulmonary disease. The severity of atrophic gastritis increases with the longer duration of COPD and with more severity of hypoxia and bronchial obstruction.

Adolescent↗
PubMed2001

[Intratracheal lymphotropic ozone therapy in erosive-ulcerous tracheitis].

Under observation there were 452 patients with chronic stenosis of hollow organs of the neck having cannulas during the period from 3 months to several years. During the tracheobronchoscopic examination it was found that 35 patients had trachea ulcers, 46 patients had erosive tracheobronchitis. The ulcers were localized on the anterior wall of the thoracic part of the trachea. Their diameter was from 1 to 2.5 cm. The ulcers were accompanied by diffuse bilateral bronchitis of the II-III degree of the inflammation intensity. 2-3 ml of ozonated sodium chloride solution with the concentration of ozone in it 5 mg/l were introduced into the ulcer edges, i.e. lymphotropically, into the submucous membrane. The same solution (40-60 ml) was used for daily sanitation of the tracheobronchial tree. Complete epithelization of the ulcers and cleansing of the bronchial tree took 3-4 curative bronchoscopies.

Animals↗
PubMed2001

[Combined treatment of patients with acute cholecystitis complicated by choledocholithiasis and mechanical jaundice].

A scheme of combined treatment was used in 72 patients with a complicated form of cholelithiasis. It included retrograde pancreatocholangiography followed by endoscopic papillosphincterotomy, intraoperative cholangiography and drainage of the common bile duct after Pikovsky. There was not a single case of transition to traditional cholecystectomy. Four complications in the postoperative period were obviated during relaparoscopy.

Acute Disease↗
PubMed2001

[Zinc's biological in the pathogenesis of duodenal ulcer].

Zinc has important role in many biochemical processes such as regeneration, growth, tissues differentiation, transmission of heredity information and so on. Its role in the duodenal peptic ulcer's pathogenesis is connected with function of gastroduodenal defence.

Duodenal Ulcer↗
PubMed2001

[Serotonin level in endocrine cells in bronchial mucosa and stomach in chronic obstructive lung diseases].

85 patients aged 26-60 years with pulmonary chronic obstructive diseases (PCOD) and gastric and duodenal erosive-ulcerous lesions were investigated. In PCOD the increased bioamines level in endocrine cells of bronchial ciliated epithelium and gastric glandular epithelium was detected before the treatment. The complex treatment in the form of bronchoscopy with lymphotropic administration of antibiotic and immunomodulator against the background of intragastral ozonotherapy contributes to the decrease in tissue edema, restoration of their trophicity and inflammatory process resolution. Against the background of therapy the serotonin content in endocrine cells of bronchial ciliated epithelium and gastric mucosa decreased to the norm.

Adult↗
PubMed2000

[Bronchoscopy in complex examination and treatment of patients with lung abscess].

Lung abscess was diagnosed during a complex examination in 115 patients. All the patients had local treatment through the bronchoscope. Cleansing of the abscess cavity takes place 1,3 times quicker in the patients who were given laser irradiation in addition to sanitation bronchoscopy or to whom immunomodulators and antibiotics were introduced lymphotropically intrabronchially, than in those with usual sanitation. The administration of 20 ml of glycerol in the abscess cavity allowed cleansing of the cavity to be 2-3 times quicker.

Adjuvants, Immunologic↗
PubMed1991

[The state of bronchial ciliated epithelium and mucociliary transport during chronic bronchitis in long-term smokers].

Endoscopic examination of the bronchial tree and investigation of pulmonary mucociliary transport by aerosol scintigraphy of the lungs were carried out in 40 patients and 10 controls. All the patients had exacerbation of chronic obstructive bronchitis. 20 of these were smokers and 20 nonsmokers. Healthy controls without lung pathology have never smoked. The findings indicate that in chronic sufferers with bronchitis and long history of smoking the rate of mucociliary clearance is reduced to 44% of the normal value and to 65% of the value for nonsmoking patients. This evidence is confirmed by the data obtained on the involvement of bronchial mucosa epithelium and at histologic examination of biopsy specimens.

Adult↗
PubMed1990

[The importance of bronchoscopy in the comprehensive examination and treatment of patients with deforming bronchitis].

5-year experience gained in three Moscow hospitals with bronchoscopic examinations of tracheobronchial lesions is analyzed. Out of 10809 procedures performed 337 were indicative of deforming bronchitis. Diagnostic evidence was furnished by x-ray, bronchography, fiber bronchoscopy with biopsy, radiologic evaluation of the lungs. Local bronchoscopic treatment was delivered to 209 patients. As a rule, the course involved 5-6 therapeutic bronchoscopies and was repeated on demand. The response was achieved in 97.6% of the patients.

Adolescent↗
PubMed1990

[Diagnostic and therapeutic bronchoscopy in long-term presence of foreign bodies in the bronchi].

Bronchofibroscopy was conducted in 9,254 patients, foreign bodies aspired long ago were found in 12 of them. All foreign bodies were radiolucent. During bronchoscopy foreign bodies were detected on the right side in 7 and on the left side in 5 patients. All were surrounded by an inflammatory swelling and covered with granulations. The foreign bodies had remained in the bronchi for 4 months to 27 years. After removal of the foreign bodies all patients were subjected to therapeutic bronchoscopy until full abatement of the inflammatory process in the bronchi.

Adult↗
PubMed1990

[Value of bronchoscopy in the diagnosis and treatment of foreign bodies of the trachea and bronchi].

10-year experience gained at the Moscow Endoscopic Center attached to S. P. Botkin City Hospital with bronchoscopic investigations for tracheobronchial pathology verification covers 14542 procedures. Foreign bodies were detected in 38 patients, of these 12 patients had aspirated the bodies long before the investigation. There were 18 males and 20 females aged from 15 to 85 years. To remove the foreign bodies, a bronchofibroscope was used in 34, a rigid bronchoscope in 4 patients. Sharp bodies and dentures were extracted with a metal loop, those of complex configuration were pulled out by a forked forceps. The removal was followed by toilet bronchoscopy. Complications due to the diagnostic or therapeutic bronchoscopy in patients with foreign bodies were not recorded.

Adolescent↗
PubMed1989

[Complications of endoscopic examinations of the upper segments of the gastrointestinal tract].

A ten-year experience with 106610 diagnostic esophagogastroduodenoscopies provided evidence of a 0.03% rate of relevant complications and 2.38% mortality. Out of 39 patients with endoscopy-related complications 5 were operated on: 4 had esophageal perforations, 1 had hemorrhage following biopsy of the ulcer. Out of 7384 therapeutic and operative endoscopies none were associated with lethal outcome. Surgery was avoided either. Complications developed in 45 patients (0.036%): in 44 patients hemorrhages occurred after electroexcision of the polyps.

Adult↗