Critique of studies of the relationship between diet and osteoporosis.
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Biomedical subjects
Publications and source records attributed to N E Johnson.
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Quality of the mother's diet, expressed as a NAR index, was significantly correlated (r = 0.301, P less than 0.05) with birth weight of the infant. Eight women who reported that they had smoked during pregnancy had infants with significantly lower birth weights (P less than 0.01), gained less weight during prenatal care (P less than 0.01), and had a lower NAR index (P less than 0.10) than 32 women who said they did not smoke during pregnancy. The relationship of birth weight to 44 maternal and environmental factors was examined by multiple regression analysis to isolate variables significantly and independently related to birth weight. This analysis showed that birth weight of the infant was positively related to number of weeks of gestation, overall dietary quality, delivery weight of the mother squared, age of the mother squared, and number of previous pregnancies squared, and negatively related to weeks of gestation squared, iron and protein intake, age of mother, number of people in the household, and number of cigarettes smoked by the mother per day. Nine factors accounted for up to 86% of the variability in birth weight. Inclusion of quality of the diet improved the prediction equations by 6 to 8%.
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Studies of family size in successive generations have found a small but persistently positive effect of size of family of orientation. Recent work has suggested that this relationship may be influenced by birth order, intergenerational change in lifestyle, and familial satisfaction. Data from a 24-year longitudinal study of women in Pennsylvania indicate that number of siblings does influence size of family of procreation. More important, this relationship is stronger among women who were first-born that later-born, stronger for those not experiencing intergenerational change than for those who changed, and stronger among those who at age 16 were satisfied with their parental family than for those who were dissatisfied.
This pilot study explored the association between a measure of water pollution caused by benzene or chlorinated solvents and the incidence of low birth weights for white residents of Michigan counties. A positive relationship between water pollution by these contaminants and the per cent of low-weight births (less than 2,500 grams, or about 5.5 pounds) resulted despite controls for the incidence of teenaged childbearing, infrequent prenatal care, and mean household income from wages or salaries. Water pollution showed an association with the incidence of low birth weight that was as strong as that between low birth weight and low prenatal care. While correlation cannot prove causation, the finding suggests that impure water may impair fetal growth in Michigan.
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