PubMed Health⌕ Search

Biomedical subjects

N E Saheb

Publications and source records attributed to N E Saheb.

11 recordsLinked to original sources
PubMed2005

Cost considerations of the new fixed combinations for glaucoma medical therapy.

OBJECTIVE: To compare the costs of the new fixed combinations for glaucoma medical therapy. METHODS: The studied drugs were: Cosopt (5-mL bottle), Combigan (5-mL bottle) and Xalacom (2.5-mL bottle). Five bottles of each drug were obtained from pharmacies, and the medications lot numbers were recorded. To calculate the drop volume, 10 drops and 1 mL of each bottle were weighed with a digital precision scale. Drop volume was calculated by the relation between volume and weight. The cost of each bottle of medication was determined from the average retail price in Canada. The prices were obtained in Canadian dollars (dollars). RESULTS: The drops of Cosopt (39.60 +/- 0.45 microL) were considerably larger than the drops of Combigan (33.75 +/- 0.60 microL) and Xalacom (30.87 +/- 0.37 microL). The average number of drops per millilitre varied from 25.25 +/- 0.29 (Cosopt) to 32.40 +/- 0.39 microL (Xalacom). Combigan presented the lowest daily cost (dollars 0.87 +/- 0.02) followed by Xalacom (dollars 1.09 +/- 0.01) and Cosopt (dollars 1.22 +/- 0.01). The average cost by year varied from dollars 316.75 +/- 5.59 (Combigan) to dollars 445.96 +/- 5.16 (Cosopt), with a total difference of dollars 129.21 per year of treatment. CONCLUSIONS: There was a statistically significant difference in average drop size and cost among the three studied drugs. Combigan presented the lowest daily cost followed by Xalacom and Cosopt.

Administration, Topical↗
PubMed1993

Short-term results of holmium laser sclerostomy in patients with uncontrolled glaucoma.

Holmium laser sclerostomy, an ab externo filtering procedure done with minimal conjunctival dissection, was performed in 55 eyes, most of which had significant risk factors for failure of filtration. The success rate was 71% at 3 months and 74% at 6 months. Major complications included choroidal hemorrhage (in one eye) and cataract (in two). These short-term results are encouraging, particularly for complicated glaucomas.

Adolescent↗
PubMed1985

Timolol: long-term Canadian multicentre study.

This paper reports a 200-week-long study of the efficacy of timolol maleate ophthalmic preparations. At centres across Canada 117 patients were studied according to a rigid protocol. Timolol maleate was shown to be an effective antiglaucomatous drug, maintaining the intraocular pressure below 22 mm Hg throughout the study in 137 (60%) of the 227 eyes. No clinically significant effect on the pulse rate or the mean perfusion pressure was demonstrated, and the medication was well tolerated, causing few side effects or adverse reactions.

Blood Pressure↗
PubMed1983

Abnormal blood vessels on the optic disc.

Twenty-five patients with abnormal blood vessels on the optic nerve head were examined both clinically and with fluorescein angiography to determine the diagnostic significance of these abnormal vessels. Six patients had congenital abnormal vessels--prepapillary or optociliary arteries or veins, or vessels associated with congenital anomalies of the disc. Nineteen patients had acquired abnormal vessels that were associated with retinal vein occlusion, chronic glaucoma, chronic papilledema, meningioma or vasculitis. The clinical and fluorescein angiographic features that differentiated these groups are discussed in detail.

Adult↗
PubMed1982

Thymoxamine versus pilocarpine in the reversal of phenylephrine-induced mydriasis.

Thymoxamine, a selective alpha-adrenergic blocker, was compared with pilocarpine in 19 patients for its reversal of phenylephrine-induced mydriasis. Both agents constricted the pupil to its original size in less than half an hour, and thymoxamine's half-life was twice that of pilocarpine's. The advantages of thymoxamine miosis, particularly in patients with narrow angles, are discussed.

Adult↗
PubMed1980

Effect of thymoxamine and pilocarpine on the depth of the anterior chamber.

Thymoxamine, an alpha-adrenergic receptor blocking agent, was compared with pilocarpine in 11 patients for its effect on the depth of the anterior chamber. In the eyes treated with thymoxamine rapid and sustained miosis occurred without a significant change in the depth of the anterior chamber. On the other hand, the miosis induced by pilocarpine was accompanied by significant shallowing of the anterior chamber.

Adult↗
PubMed1978

Response to topical epinephrine in chronic open-angle glaucoma.

The epinephrine pressure reduction was determined in 32 patients with elevated intraocular pressure (IOP) and 18 patients with untreated chronic open-angle glaucoma. The prevalence of responders was 53% of those patients with elevated IOP and 56% in those patients with open-angle glaucoma. This lack of difference between the two groups is suggestive of the need for caution before applying epinephrine in clinical practice as a predictive factor of future field loss.

Analysis of Variance↗