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Biomedical subjects

N E Wiseman

Publications and source records attributed to N E Wiseman.

22 records · Page 2Linked to original sources

Neonatal arterial occlusion with ischemic limb gangrene.

Arterial occlusion in the extremity of a neonate is a rare event of obscure etiology. The diagnosis implies an urgent situation which may result in extremity gangrene and ultimate loss of limb. In contrast, early diagnosis and appropriate management should result in preservation of a normal limb. The key to successful management appears to be an awareness of this common clinical condition in an uncommon clinical setting.

Amputation, Surgical↗

Constant negative pressure: an adjunct in the treatment of gastroschisis.

Three cases of gastroschisis are described, managed surgically in the neonatal period by staged reduction employing a dacron reinforced silastic sac. All three cases were treated during the postoperative period with the application of constant negative pressure around the thorax and abdomen. Reduction of the eviscerated mass appeared to be accelerated and all three cases survived. The possible benefits of constant negative pressure around the thorax and abdomen in the treatment of gastroschisis are discussed.

Abdominal Muscles↗

Assessment of pulmonary wedge resection for the treatment of lung metastases.

Wedge resection for pulmonary metastases was performed on 18 children suffering from a variety of malignant tumors. The overall survival rate was 39%. However, tumor recurred at or near the site of resection in half the patients. A more extensive resection, such as lobectomy, should be considered for most patients. Wedge resection should be reserved for tumor involving many lobes or for neoplasms having a demonstrated sensitivity to chemotherapy and irradiation.

Adolescent↗

Congenital ependymoblastoma presenting as a sacrococcygeal mass in a newborn: an immunohistochemical, light and electron microscopic study.

We describe a case of congenital ependymoblastoma presenting as a subcutaneous mass in the sacrococcygeal area of a newborn male. The tumor was composed of primitive cells disposed in compact sheets and cords and exhibiting focal ependymal differentiation. No other line of cellular differentiation was identified by either immunohistochemistry or ultrastructural study. Elevated serum alpha-fetoprotein was found, which decreased following surgical extirpation of the tumor. We propose that this tumor had its origin in the ependymal medullary vestige, similar to other sacrococcygeal ependymomas.

Antigens, Neoplasm↗