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Biomedical subjects

N EMMELIN

Publications and source records attributed to N EMMELIN.

At least 37 records · Page 2Linked to original sources
PubMed1959

Supersensitivity due to prolonged administration of ganglion-blocking compounds.

Repeated subcutaneous injections of ganglionic blocking agents in cats were found to cause a supersensitivity towards adrenaline in the submaxillary gland and the nictitating membrane. The supersensitivity resembled that produced by preganglionic denervation, namely section of the chorda tympani in the case of the gland and of the cervical sympathetic trunk in the case of the membrane. The blocking compounds used were chlorisondamine chloride and hexamethonium. With the former, the sensitization could be obtained in the normally innervated structures. When hexamethonium was used, however, the effect on the gland could be produced only if the synapse had been made particularly susceptible to the blocking action of this agent; this was achieved by cross-suture experiments.

Animals↗
PubMed1959

Effects of cross-suture and of injected acetylcholine on the supersensitivity of denervated striated muscle.

The sensitivity of the tongue muscles to acetylcholine was examined in repeated experiments on cats anaesthetized with hexobarbitone. The supersensitivity which developed after section of the hypoglossal nerve was found to decrease when the muscles, after cross-suture, became re-innervated from the vagus or the chorda-lingual nerve. The supersensitivity caused by denervation could also be reduced by injecting acetylcholine repeatedly during six hours in acute experiments.

Acetylcholine↗
PubMed1958

The effect of anticholinesterases on the parotid gland after parasympathetic decentralization or denervation.

Anticholinesterases (eserine, ethyl pyrophosphate, paraoxon) were injected into the parotid ducts and found to cause a secretion of saliva. After previous preganglionic, parasympathetic denervation the effects were increased above normal; this was probably due to the supersensitivity to acetylcholine which develops after the operation. After previous postganglionic, parasympathetic denervation, on the other hand, the effects were much reduced, in spite of a pronounced supersensitivity towards, for example, acetylcholine. The cause of this "subsensitivity" towards cholinesterase inhibitors is discussed.

Acetylcholine↗