Biomedical subjects

N Egund

Publications and source records attributed to N Egund.

At least 37 records · Page 2Linked to original sources

PubMed1995

Subsidence of tibial components in knee arthroplasty. A comparison between conventional radiography and roentgen stereophotogrammetry.

RATIONALE AND OBJECTIVES: To assess the ability of conventional radiography to identify subsidence of tibial components. METHODS: Forty-three cases of knee arthroplasty were followed for 4 years using roentgen stereophotogrammetric analysis as the gold standard. RESULTS: Roentgen stereophotogrammetric analysis showed subsidence in all uncemented prostheses, whereas two thirds of the cemented prostheses subsided. Medially, the sensitivity of conventional radiography was low, 25%, whereas the specificity was 83%. For the other regions, the sensitivity was almost 100%, although the specificity was as low as 66% frontally and dorsally. CONCLUSIONS: Medially, where most prostheses were inserted with a slight overhang, conventional radiography identified subsidence correctly. Laterally, frontally, and dorsally, however, conventional radiography overestimated the subsidence by a factor of 2 to 3. This error was caused by bony protrusions arising in the cranial direction from the uncovered bone surfaces, thus changing the points of reference. This problem arose more commonly in uncemented cases, whereas cement seemed to seal the bone.

Biomechanical Phenomena↗

PubMed1994

Effect of radiographic contrast media on granulocyte phagocytosis of Escherichia coli in a whole blood flow cytometric assay.

RATIONALE AND OBJECTIVES: Earlier studies have demonstrated an adverse effect of radiographic contrast media (CM) on granulocyte phagocytosis. Most studies in the past have depended on granulocyte separative procedures that may themselves affect granulocyte functions. This study was performed to evaluate the effect of CM on phagocytosis using a flow cytometric assay allowing more physiological assay conditions. METHODS: Twenty consecutive patients were blindly randomized to receive the nonionic ratio 3.0 CM iohexol or the ionic ratio 3.0 CM ioxaglate for intravenous urography. Granulocyte phagocytic potential was measured before and at 1, 5, and 20 minutes after CM administration with a flow cytometric whole blood method evaluating the ingestion of complement- and immunoglobulin G (IgG)-opsonized fluorescent Escherichia Coli bacteria. RESULTS: The ability of granulocytes to phagocytize opsonized E. Coli was adversely affected by both CM used. Compared with baseline values, significantly decreased phagocytic activity was observed for iohexol at 1, 5, and 20 minutes and for ioxaglate at 1 and 5 minutes. The largest decrease with ioxaglate was from 85.3 +/- 10.5 to 69.3 +/- 16.3 (5 minutes), and the largest change with iohexol was from 87.1 +/- 8.5 to 74.5 +/- 15.9 (5 minutes). CONCLUSION: These results confirm earlier reports that ionic and nonionic CM adversely affect the phagocytic ability of granulocytes after intravenous administration.

Escherichia coli↗

PubMed1994

Sonography and intracapsular pressure in Perthes' disease. 39 children examined 2-36 months after onset.

39 children with Legg-Calvé-Perthes Disease (LCPD) and with a radiographically unsatisfactory development were examined with sonography regarding synovitis and with intracapsular pressure recording and aspiration performed 15 (2-36) months after the onset of symptoms. The mean anterior sonographic capsular distension was 3.0 (1.0-7.0) mm greater than that of the contralateral, asymptomatic hip. The mean intracapsular pressure was 4.5 (0-11.5) kPa with the hips in extension and neutral rotation, 9.7 (1.3-27.3) kPa with the hips in extension and inward rotation and 0.9 (-0.8-4.7) kPa in 45 degrees of flexion. We conclude that these children have synovitis as diagnosed sonographically. This synovitis is probably symptomatically and prognostically important in LCPD due to increased intracapsular pressure, with pain, a decreased range of motion and, potential joint contracture.

Child↗

PubMed1994

Femoral head shape in Legg-Calvé-Perthes disease. Correlation between conventional radiography, arthrography and MR imaging.

Twenty-three children with Legg-Calvé-Perthes disease were examined to determine the femoral head shape. We evaluated and correlated conventional radiography, arthrography and MR imaging. In the a.p. view, measurements were obtained from the center of the femoral head along the bony or cartilaginous outline at 30 degrees intervals. Maximum flattening of the cartilaginous outline appeared laterally, 60 degrees from the center of the baseline of the epiphyseal index and the caput index. Maximum flattening of the bony outline was found at 75 degrees. Arthrography and MR imaging gave the same information about the shape of the femoral head cartilage. The bony femoral head shape on conventional radiographs in the a.p. view did not reflect the cartilage shape obtained by MR and arthrography.

Arthrography↗

PubMed1994

Assessment at CT of the rheumatoid shoulder with surgical correlation.

Eleven shoulders in 10 patients with rheumatoid arthritis were examined by conventional radiography and CT prior to cup hemiarthroplasty of the humeral head and the results were compared with the surgical findings. There was good agreement between preoperative CT and surgical findings. Humeral head cavities and erosions, with cortical boundaries, could be seen more accurately at CT than at conventional radiography. The HU of their contents corresponded to those of soft tissue, being granulomatous in nature at surgery. In 8 humeral heads CT disclosed large areas of fatty degeneration of bone marrow with HU between -10 HU and -76 HU that were not visible on the conventional radiographs. These "fatty cysts" had no cortical boundaries, unlike inflammatory granulomas, but both lesions may influence the surgical approach to hemiarthroplasty.

Adult↗

PubMed1994

Posttraumatic osteolysis of the pubic bone simulating malignancy.

Posttraumatic osteolysis (PO) of the os pubis is a diagnostic entity characterized at radiography by rapidly progressing destructive changes in fractures of the pubic body or rami. Fourteen patients with PO are here reported of whom in 8 the radiographic course of the condition was followed. They were all post-menopausal women and 7 were predisposed to osteopenia. The primary fractures were related to mild trauma in 7 patients and 7 had insufficiency fractures. Four patients had bilateral symmetrical PO. All 14 patients had concomitant insufficiency fractures of the sacrum observed at radiography, CT, scintigraphy or MR, probably due to pelvic instability caused by the PO of the os pubis. Symptoms of the sacral fractures usually dominated the clinical condition. Bony healing of the PO did not occur in any of the patients, but in all 8 patients followed radiographically, the fractures of the sacrum healed clinically and at CT. Knowledge about the condition is important to avoid unnecessary biopsy of the PO considered a metastatic lesion and/or extensive diagnostic search for a primary tumor.

Aged↗

PubMed1993

Radiographic assessment of sagittal knee instability in weight bearing. A study on anterior cruciate-deficient knees.

In 16 patients with chronic, symptomatic anterior cruciate ligament-deficient knees, sagittal displacement was studied in the standing position using fluoroscopic control and a simple device to support the knee. In slight weight bearing all knees but one had normal femorotibial alignment in the lateral view. During full weight bearing sagittal displacements between 2 mm and 17 mm were recorded in 14 patients. The largest displacements were obtained at different angles of inclination of the leg and flexion of the knee joint and were independent of the point of support of the knee joint. The reproducibility of this new standing technique was within 2 mm. A high correlation with previous methods of radiographic measurements of sagittal laxity was found. By the use of the normal relationship between the tibial eminence and the femoral condyles it is possible to record and measure sagittal displacements on a single lateral radiograph of the standing knee joint.

Adolescent↗

PubMed1993

Size of osteonecrosis of the knee.

In the Swedish Multicenter Study of Knee Arthroplasty, 115 knees in 110 patients with knee osteonecrosis represented all reported cases treated with knee arthroplasty in the period from 1975 to 1986. Primary medial femoral condyle osteonecrosis was the most common osteonecrosis reported (89%). Preoperative roentgenograms were staged according to the type of osteonecrosis and classified according to the grade of arthrosis. Detailed measurements of the size of the lesion were also performed. For primary medial femoral osteonecrosis, the width of the lesion averaged 45% of the condyle. The mean width of the lesion (anteroposterior size) was 21 mm and the mean length (lateral size) was 34 mm. The mean depth on lateral roentgenograms was 6 mm. There was a high correlation of results among the various methods of measurement. Using regression analysis, it was possible to approximate the volume of the lesion even from a single measurement of the width on anteroposterior view. The size of osteonecrosis of the knee can be used to plan resection and select the implant design.

Adult↗

PubMed1992

Instability after anterior cruciate ligament rupture. Measurements of sagittal laxity compared in 11 cases.

Manual tests and 2 external devices were used together with roentgen stereophotogrammetry (RSA) and an active weight-bearing radiographic method to measure the sagittal laxity in 11 knees with anterior-cruciate-ligament rupture. In 5 knees no ligament surgery had been performed (unstable knees) and in 6 knees a reconstruction had been performed one year before the examination (stable knees). There were positive correlations between all methods, including the manual tests when all knees, both stable and unstable, were analyzed together. However, the mean values of the total displacement differed between the methods, especially when comparing the weight-bearing radiographs with the three other methods. Some knees with substantial displacement during passive loading did not show any displacement when weight bearing; the measurements thus depended on both the ligamentous laxity and the patient's neuromuscular control of the joint. When the stable knees were analyzed separately, higher mean values were recorded with the external devices than with RSA using 180 N load. This could be explained by an error from soft tissue deformation which added to the skeletal displacement when the external devices were used.

Adolescent↗

PubMed1992

The natural history of recurrent dislocation of the patella. Long-term results of conservative and operative treatment.

From 1970 to 1978, 29 patients had a unilateral operation for bilateral recurrent dislocation of the patella. We examined 21 of them at a mean of 14 years postoperatively. Eighteen of these patients had evidence of generalised joint laxity. Six of the operated knees and four of the unoperated knees still had recurrent dislocations. The operated knees were clinically worse, with a significantly higher incidence of osteoarthritis. We concluded that the operations used to treat recurrent dislocation of the patella may have had short-term benefits, but did not cure the patients in the long term.

Adolescent↗

PubMed1992

Contribution of the umbilical and portal veins to the hepatic blood supply of guinea pig fetuses--an angiographic study.

The interlobular distribution of the umbilical and portal venous blood flow within the liver was examined in 35 guinea pig fetuses between 59 and 65 days of gestation. Contrast medium was injected into the umbilical or vitelline vein, and its passage through the liver was monitored by serial angiography. In four experiments, injections were made into both the umbilical and vitelline veins of the same fetus. To ease interpretation of the angiograms obtained in vivo, we also made a postmortem examination of livers in which the venous system had been filled with an aqueous suspension of barium sulphate in gelatin. These combined experiments demonstrated no passage of contrast medium from the placenta to the inferior vena cava, which is in accordance with independent evidence that the term guinea pig fetus lacks a functional ductus venosus. The area supplied by the umbilical and portal veins was clearly and consistently delineated. The umbilical vein supplied the left lobe and the left sublobe of the quadrate lobe. The portal vein supplied the right lobe, the smaller caudate lobe, and all or most of the right sublobe of the quadrate lobe. This pattern of distribution appears to be determined by flow and pressure gradients within the hepatic circulation.

Animals↗

PubMed1992

Cartilage regeneration after proximal tibial osteotomy for medial gonarthrosis. An arthroscopic, roentgenographic, and histologic study.

High tibial osteotomy for medial gonarthrosis was performed in 28 patients (28 knees). At the time of surgery, arthroscopy was also performed and a cartilage-bone biopsy was obtained. Postoperatively, 15 patients were randomized to a cylinder plaster cast, whereas 13 patients had a hinged cast brace for early knee mobilization. At follow-up examination, two years after surgery, 16 patients accepted an arthroscopic examination with a cartilage-bone biopsy. In overcorrected knees, cartilage regeneration was found in eight of 14 patients on the medial tibial condyle and in nine of 14 on the medial femoral condyle. The main repair feature was proliferation of fibrocartilage, which covered bone and areas of fibrillated cartilage and filled vertical clefts in hyaline cartilage. The hyaline cartilage showed an increased cellularity with numerous nests of proliferating chondrocytes. No correlation was found between clinical outcome and the degree of cartilage regeneration as observed by arthroscopy, biopsy, or roentgenography. Knees with a brace postoperatively had better knee flexion two years after surgery. No difference in cartilage regeneration was recorded between knees with a plaster cast or a cast brace postoperatively.

Adult↗

PubMed1991

Ten-year results of tibial osteotomy for medial gonarthrosis. The influence of overcorrection.

The results in relation to the correction achieved 1 year after surgery of a series of tibial osteotomies in 50 patients (52 knees) are presented with a total observation time of 10 years. Mean age at the time of osteotomy was 56 years. Overcorrected knees had a significantly better result after 10 years. Progress of gonarthrosis occurred in 6/34 overcorrected knees compared with 3/4 in the normo- and undercorrected group. One out of 34 overcorrected knees recurred in varus. Five knees were revised by knee arthroplasty or reosteotomy one of which was overcorrected.

Adult↗

PubMed1991

Legg-Calvé-Perthes disease: imaging with MR.

Magnetic resonance (MR) imaging studies were obtained to evaluate the shape of the cartilaginous femoral head and the adequacy of femoral acetabular containment in 35 children with Legg-Calvé-Perthes disease (LCPD). MR results for 24 of the 35 children were compared with results at arthrography. The shape of the cartilaginous femoral head was well identified with MR imaging, but, with arthrography, less information could be obtained about the medial and lateral aspects of the cartilaginous capital epiphyses in nine and three cases, respectively. Thirteen children underwent surgery; remodeling and regained femoroacetabular congruity of the articular surfaces following derotation varus osteotomy was identified in seven of 10 who underwent repeat MR imaging. In addition, MR images and conventional radiographs of the hips were compared. The radiographically identifiable distribution of the bone necrosis of the capital epiphysis correlated well with that demonstrated on MR images. MR imaging is a valuable non-invasive procedure with which to obtain information about the status and treatment of the cartilaginous femoral head in children with LCPD.

Child↗

PubMed1991

Proteoglycan epitope in synovial fluid in gonarthrosis. 28 cases of tibial osteotomy studied prospectively for 2 years.

High tibial osteotomy was performed for medial gonarthrosis in 28 patients. Preoperatively, and at 3, 12, and 24 months after surgery, clinical and radiographic examinations were made, and joint-fluid samples were aspirated. Arthroscopy was performed preoperatively and at 24 months. Immunoassay of proteoglycan epitope in joint fluid showed an increase in concentration at all times as compared with a reference population with normal knee joints. An increase in both the concentration and the total amount of proteoglycan epitope in joint fluid was noted at 3 months postoperatively with a return to preoperative values at later times. Regrowth of fibrocartilage did not correlate with proteoglycan epitope data.

Adult↗

PubMed1991

Prognosis for patients with medial gonarthrosis. A 16-year follow-up study of 189 knees.

All 189 knees (157 patients) that had had primary medial compartment arthrosis in 1972 were followed until 1988. After 14 years, tibial osteotomy had been performed in 85 knees and arthroplasty in 33 knees. No major surgery had been performed in 71 knees; of these 71 knees, 31 patients (40 knees) had died. Of the remaining 23 patients (31 knees), the majority had an unsatisfactory knee and managed only on a low activity level. In 20 of 24 knees, progress of the arthrosis was recorded roentgenographically. Because natural course of medial gonarthrosis has a poor prognosis, the majority of patients suffering from this condition will eventually have major knee surgery.

Activities of Daily Living↗

PubMed1990

Diagnosis of displaced ulnar collateral ligament of the metacarpophalangeal joint of the thumb.

In a prospective study of 24 consecutive patients with posttraumatic instability of the metacarpophalangeal joint of the thumb, clinical examination including instability tests and palpation of displaced ulnar collateral ligaments was used to separate the patients into two groups--nondisplaced and displaced ruptures. Palpable displaced ruptures were treated surgically, whereas nonpalpable ruptures were interpreted as nondisplaced and were treated with plaster, irrespective of the instability. At follow-up 1 year later both groups showed similar results with respect to stability, strength, and function. Our results indicate that a clinical examination with palpation of the torn ligament ends identifies displaced ruptures of the ulnar collateral ligament, i.e., those cases needing surgery. Nondisplaced ruptures might be treated nonoperatively.

Adolescent↗

PubMed1990

CT scans and lipohaemarthrosis in hip fractures.

Computed tomography was performed on 40 patients with recent hip trauma. Radiographs of 25 showed a fracture of the femoral neck with slight displacement; 24 of these had intra-articular fluid and 20 had a lipohaemarthrosis on the CT scan. In 15 patients, radiographs at the time of admission were normal but suspicion of fracture remained. A fracture was later verified in five patients, four of whom had lipohaemarthrosis on admission. In the remaining 10 patients no fracture could be detected; only one patient had a hip joint effusion but no free fat. Thus all 24 patients with lipohaemarthrosis had an intracapsular fracture of the hip. We suggest CT for patients with hip trauma and negative radiographs. The presence of a lipohaemarthrosis of the hip strongly suggests an intra-articular fracture of either the femoral neck or the acetabulum.

Aged↗