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Biomedical subjects

N Elkin

Publications and source records attributed to N Elkin.

4 recordsLinked to original sources
PubMed1999

The International Prognostic Index predicts for outcome following autologous stem cell transplantation in patients with relapsed and primary refractory intermediate-grade lymphoma.

We analyzed a group of 51 patients with primary refractory and relapsed intermediate-grade lymphoma (IGL) from the time of initiation of three cycles of second-line chemotherapy, ifosfamide, carboplatin and etoposide (ICE), in whom the intent was to administer curative high-dose chemoradiotherapy and autologous stem cell transplantation (ASCT). We sought to determine if the International Prognostic Index (IPI) assessed immediately prior to ICE, second-line IPI (sIPI), was predictive of outcome. The response rate to ICE-based chemotherapy was 69%, and 47% of the transplanted patients remain failure-free at 2.5 years. Stratification of patients based upon the sIPI demonstrated a superior 2.5 year failure-free survival (FFS) curve for patients with low (I) or low-intermediate (II) risk disease vs. those with high-intermediate (III) and high (IV) risk disease (45% vs. 9%, P<0.001). When the analysis was restricted to those patients with chemosensitive disease, the sIPI (I/II vs. III/IV) also separated patients into two distinct prognostic groups (59% vs. 20%, P = 0.04). Patients with sIPI I and II disease have a favorable outcome with ICE chemotherapy and ASCT. However, patients with sIPI III and IV disease derive limited benefit from this treatment strategy, and new approaches are needed in this patient group.

Adult↗
PubMed1997

Severe hepatopathy in geese and broilers associated with ochratoxin in their feed.

The feeding of a shipment of imported corn was associated with a severe reduction in growth and increased mortality in geese, and increased mortality in broilers. Pathological examinations revealed hepatopathy, visceral gout and mild nephropathy in geese, and in broilers an hepatopathy, which was often severe, and ascites. Samples of feed from affected geese farms were examined for up to 24 mycotoxins, and ochratoxin was found in 6 of 15 samples at levels up to 930 ng/g. The syndrome was experimentally reproduced by feeding geese and broilers suspect feeds with the natural ochratoxin contamination. It is believed that another, unidentified, mycotoxin was the major cause of the hepatotoxicity, and that ochratoxin served in this case as an indicator of a multi-mycotoxin involvement.

Animal Feed↗
PubMed1985

Load bearing and suspension characteristics of airsplint as a temporary prosthesis.

Maximum weight bearing observed, using a static weighing scale, in above-knee amputees wearing an airsplint, with a foot, was 10 kg and in below-knee amputees 11 kg with inflation pressures of 40 mmHg. While airsplints with a foot permitted greater weight bearing before deformation occurred, the increase is judged to be of little clinical advantage. Use of an airsplint without a foot would be more efficient for immediate post-operative dressing and for early ambulation in the parallel bars as it is less cumbersome and not subject to toe drag in the swing phase of gait. With the type of airsplints studied inflation pressures above 45 mmHg offered no advantage in terms of weight bearing in the below-knee amputee. In the above-knee amputee similarly, inflation pressures over 40 mmHg offered no advantage and had the effect of reducing the suspension of the prosthesis on the stump.

Air Pressure↗