Biomedical subjects
Publications and source records attributed to N Ertekin.
The synthesis of a series of thiazolo[3,2-a]pyrimidine derivatives were described. The structures of the compounds were elucidated by IR, 1H-NMR, 13C and elementary analysis. The compounds were evaluated for their calcium antagonistic activities using nifedipine as standard compound. All of the compounds were found to be less potent than nifedipine.
Fifteen chronic alcoholic male patients with impotence have been investigated with the electrophysiological method of sympathetic skin potentials recorded from the genital skin and with the electrically induced bulbocavernosus reflex. Both electrophysiological tests did not differ from those of normal controls. It was proposed that there is no obvious role of the peripheral neuropathic factors in the pathogenesis of impotence in chronic alcoholism.
Skin potentials (SP) were evoked by peripheral nerve stimulation from the hands and feet of 41 and from the genital skin of 28 male, controls. The same methods were also applied in 10 functionally impotent cases, 32 diabetic impotent and 8 diabetic normopotent cases. The SP was easily obtained from all 3 sites in all normal subjects and in 10 functionally impotent cases. The SP recorded from the genital skin was either absent or abnormal in 53% of diabetic impotent cases with or without polyneuropathy, while the incidence of abnormalities encountered in the hand and/or foot recordings was 28%. In 8 diabetic normopotent cases the SP recorded from the genital and extremity skin were completely normal. SP recorded from the genital skin is a useful method of evaluating the autonomic-sympathetic dysfunction causing impotence, especially in patients who may have autonomic disorders either located in lumbosacral spinal cord and its efferents, or generalized autonomic-peripheral dysfunction.
In 64 patients with various central and peripheral nervous system disorders, the lumbar erector spinal muscle responses evoked by electrical stimulation of the brachial plexus at Erb's point or of the posterior tibial nerve in the popliteal fossa while standing were recorded. These responses were either absent or delayed in patients with involvement of the posterior columns. The latency of the responses was the same in patients with cerebellar syndromes, Parkinsonism, spastic hemiparesis or vestibular ataxia as in normal subjects. The size of the responses was diminished in patients with cerebellar syndromes and increased in those with Parkinsonism and spastic hemiparesis as compared with normal subjects.
In 55 normal adult subjects standing erect, stable EMG responses could be recorded from the lumbar erector spinae muscles in response to unilateral sudden are abduction produced by single electrical stimuli applied to the brachial plexus at Erb's point, or to knee and ankle movement produced by stimuli to the posterior tibial nerve in the popliteal fossa.
The effects of continuous vibration on sural nerve action potentials were investigated in 15 subjects. The results show that continuous vibration applied to the sural nerve innervated skin area produces an amplitude reduction of the sural nerve action potentials on both painless and painful stimulation conditions. This amplitude decrease is attributed to an impulse blockage of the large diameter afferent nerve fibers.
The conduction velocity along the nociceptive flexor reflex afferent nerve fibres was investigated in human subjects. The posterior tibal nerve was stimulated at two sites by single painful electrical shocks of 1.0 ms duration and with adequate intensity and the reflex EMG discharges were recorded from the short head of the biceps femoris muscle. The fastest reflex conduction velocity along the posterior tibial nerve between the ankle and the popliteal fossa was about 10-25 m/s. Thus the fastest flexor reflex afferent fibres associated with a painful sensation were thought to be included in the A-delta group of cutaneous afferent nerve fibres.