[The effect of prazosin and korinfar on the central hemodynamics and liver blood flow in hypertension patients (based on 2-dimensional Doppler echography)].
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Biomedical subjects
Publications and source records attributed to N F Beresten'.
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A separate estimation of blood flow in the portal and hepatic veins using ultrasonic two-dimensional tomography and impulse Doppler echography of the liver was tried in 30 chronic sufferers with hepatitis versus 31 healthy controls. Two-dimensional impulse Doppler echography recorded the blood flow spectrum in the right hepatic vein at the site of its entering of vena cava inferior as well as in the portal vein at the portal fissure simultaneously with ECG. The index of portal blood flow and that of right hepatic vein flow in systole are proposed. The above method warrants a separate estimation of hepatic circulation in hepatic pathology whereas its combination with ultrasonic tomography increases its diagnostic potential at early stages of hepatic impairment. The analysis of the central and hepatic hemodynamics established hepatic circulation participation in regulation of central hemodynamics.
The cytogenetic activity of food dyes was examined in the experiments on male C57B1/6 mice which were orally given during 5 days the following daily doses: Tartrasine (E102), 0.5 and 5.0 mg/kg; Indigo carmine (E132), 1.4 and 14 mg/kg; Canset yellow (E110), 0.17 and 1.7 mg/kg; Cochenillerot A (E124), 0.63 and 6.3mg/kg; Azorubin (E122), 1 and 10 mg/kg and Patentblau V (E131), 0.08 and 0.8 mg/kg. Five hundred metaphase slides each were analyzed in the control and experimental test series. The findings may conclude that the dyes tested within the above dose ranges do not induce any increase in the level of cells with chromosomal damages in the inbred animals.
The present paper describes the possible clastogenic activity of the following synthetic sugar substitutes, such as cyclamate in daily doses of 11 and 110 mg/kg, saccharin, 5 and 50 mg/kg, acesulfam, 15 and 150 mg/kg, sucralose, 15 and 150 mg/kg, aspartame, 40 and 400 mg/kg, orally given to C57Bl/6 mice during 5 days. No clastogenic activity was found in the compounds tested.