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Biomedical subjects

N F Gumpert

Publications and source records attributed to N F Gumpert.

8 recordsLinked to original sources
PubMed1982

Establishing a research fund in a hospital pharmacy department.

Development of a fund to support research in the pharmacy department of a community hospital is described. Finding research money difficult to obtain from industry or government sources, members of the pharmacy staff created a research fund from their own resources. Staff members donated time spent preparing and presenting educational programs such as seminars and workshops, and profits from these programs were designated for research. In addition, the hospital allowed direct contributions to the fund through payroll deductions. A board comprising pharmacists, physicians, and the hospital's legal counsel was formed to request, receive, and review grant proposals and to award funds. Objectives of the research fund were to facilitate staff development and recognition; improve communication and managerial skills of those planning the program, administering it, and conducting the actual research; and enhance recruitment efforts. More than +21,000 has been raised, and the first project, a microcomputer-based pharmacokinetic dosing program, has been completed.

Pharmacy Service, Hospital↗
PubMedDate not supplied

Gentamicin nephrotoxicity: application of multivariate analysis.

A retrospective study was conducted to identify patient risk factors associated with gentamicin nephrotoxicity using multivariate analysis. Patients were evaluated for nephrotoxicity using an algorithm that considers serum creatinine, previous general experience with the drug, alternative etiologic candidates, timing of events, drug concentrations or evidence of overdosage, dechallenge, and rechallenge. There were 220 patients who met the criteria for inclusion in the study (103 men and 117 women). Variables found not to be significant discriminators between toxic and nontoxic patients included height, weight, sex, dose, estimated peak gentamicin concentration, age, and initial renal function. Variables that were found to enter into the discriminant analysis included presence of complicating factors with nephrotoxic potential, number of concurrent potentially nephrotoxic drugs, intensity index or estimated trough gentamicin concentration, and the total dose or treatment duration. Two models were developed; the probability of correctly classifying a patient as toxic was 63.5% and 65.4%, and as nontoxic was 72.1% and 68.8% for the two models, respectively. Although the discriminant models developed were statistically significant, the discrimination between toxic and nontoxic patients was not satisfactory to allow development of a generalized predictive model. Multivariate techniques were found to be essential in allowing for the differentiation of variables causing gentamicin nephrotoxicity.

Adult↗