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Biomedical subjects

N F Khmara

Publications and source records attributed to N F Khmara.

At least 19 recordsLinked to original sources
PubMed1991

[Lipid peroxidation and the antioxidant system in the therapeutic effect of hypobaric hypoxia in patients with neurologic manifestations of lumbar osteochondrosis].

The hypobaric therapeutic effect dependence on the initial state of lipid peroxidation (LPO) and on its short-term activation after 3-4 sessions has been shown. The peroxidation action of hypobaric therapy (HBT) was consistent with a substantial increase of the correlation coefficient and regression between diene conjugates (DC) and tocopherol as well as a decrease of ascorbic acid and glutathione peroxidase activity. LPO activation did not take place in patients without changes in the clinical symptoms. Clinical improvement was shown by 94% of patients with the initial content of DC less than 2 o. u/ml. At higher DC values the therapeutic effect was lacking in 50% of cases and in 14% of cases where HBT was employed in combination with unithiol++. The normal level of LPO did not require the use of antioxidants in HBT. Recommendations have been made for differentiated use of HBT and of HBT plus antioxidants. The role of the prooxidant action of HBT in the formation of adaptation mechanisms is discussed.

Adult↗
PubMed1989

[The pH of the culture medium as a factor regulating the functional properties of thrombocytes].

Thrombin-induced time-dependent alteration of light-transmission was studied in platelet suspensions with varying pH in calcium-free media, and in the presence of calcium ions. It has been shown that thrombin-induced platelet aggregation and preaggregation stage character are determined by the pH-dependent structural and functional state of the platelet membrane systems.

Adenosine Diphosphate↗
PubMed1986

[Role of glycosaminoglycans in the pathogenesis of vertebral osteochondrosis (clinico-experimental study)].

Glycosaminoglycans (GAGs) and their fractions were measured in relation to age. The material for examination consisted of labile intervertebral disks (27 cases) obtained during operations for discogenic lumbosacral radiculites and disks obtained from people (n = 35) who had died in accidents. The findings showed marked deviations in the total GAGs and their fractions in labile disks, which differed from age-specific changes. The changes revealed in animals with cholesterol atherosclerosis (50 rabbits) and chronic papain degeneration (56 rabbits) resembled those characteristic of vertebral osteochondrosis. It is concluded that degenerative dystrophic changes in osteochondrosis may be induced by both atherosclerotic process and an elevated activity of lysosome enzymes.

Adult↗
PubMed1984

[Chemiluminescence of thrombocytes in thrombin-induced aggregation].

Chemoluminescence induced by thrombin and aggregation of thrombocytes as well as effect of aspirin on the reactions were studied. Intensity of thrombin-induced chemoluminescence correlated with accumulation of malonic dialdehyde and hydroperoxides in cells. Chemoluminescence of thrombocytes appears to occur after the thrombin stimulation of cyclooxygenase pathway of arachidonic acid oxidation in cells.

Arachidonic Acid↗
PubMed1983

[pH-dependent conformational changes in thrombocyte proteins].

A study was made of the medium pH influence on structural states of platelets by optical methods. Within the pH range (6-8), two pH induced reversible changes of platelet state were observed. A conclusion is made that the structural rearrangements in platelets induced in the medium by changes in hydrogen ion concentration may involve some rearrangements in platelet proteins, and thus acting as a factor regulating platelet function.

Blood Platelets↗
PubMed1976

[Thrombocyte lactate dehydrogenase isoenzymes in patients with ischemic stroke].

It was established that in the acute period of the ischemic stroke in the maiority of cases a change of isoenzyme structure of LDG thrombocytes was due to a decrease of LDG3 activity. In a number of patients the dominant change in the spectrum was determined by LDG and LDG4 fractions. The changes were of a stable character up to 10 weeks. LDG4 increase was characteristic of the isoenzymes spectrum in the patients with a severe development of the disease and in the patients in the remote period of the stroke. The obtained data can serve as a criterion for evaluating the adaptive changes in acute brain ischemia.

Adult↗
PubMedDate not supplied

[Activity of lactate dehydrogenase and its isoenzymes in the thrombocytes in different forms of cerebral circulatory disorder].

In thrombocytes of patients with ischemic and hemorrhagic insult a transformation in the isozyme spectrum of lactate dehydrogenase was observed without an alteration in the reaction rate. In this case LDH3 was decreased and LDH1 and LDH4 were increased. The correlation was not found between the type of insult and the character of the isozyme spectrum. The alterations were considered as an adaptive mechanism and the reflected the extent of immediate or intermediate effect of ischemia on thrombocytes.

Adolescent↗
PubMedDate not supplied

[The chlorine e6-photosensitized inhibition of human thrombocyte aggregation].

ADP-induced aggregation of platelets in the presence of chlorin E6 under the action of visible light depending on the pigment concentration and the time of light action was studied. It was shown that the photosensitized effect of chlorin E6 on the platelet-enriched plasma results in platelet aggregation inhibition.

Adenosine Diphosphate↗