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Biomedical subjects

N F Suttle

Publications and source records attributed to N F Suttle.

At least 55 records · Page 3Linked to original sources
PubMed1976

Copper metabolism in experimental Border disease.

The proposal that hypocupraemia and hypocuprosis are characteristic manifestations of Border disease and of aetiological significance has been investigated. Mean plasma copper concentrations in 65 affected and 47 unaffected lambs were similar and in a controlled experiment, plasma and tissue copper concentrations tended to be higher in affected lambs than in controls. It is concluded that hypocupraemia and hypocuprosis are not consistent features of Border disease and thus have no aetiological significance.

Animals↗
PubMed1975

The role of organic sulphur in the copper-molybdenum-S interrelationship in ruminant nutrition.

1. The ability of organic and inorganic sulphur to influence the copper and molybdenum metabolism of sheep was compared in a series of three 2 X 2 factorial design experiments. In each experiment, four groups of five to seven hypocupraemic ewes were repleted with a basal diet supplemented with 6 mg Cu/kg and containing S and Mo at one of two concentrations, 1 or 4 g S and 0-5 or 4-5 mg Mo/kg respectively. Sodium sulphate (Expt I), methionine (Expt 2) or cysteine (Expt 3) were used as the S sources. Cu and Mo concentrations in plasma were estimated in each experiment and in Expt 3 the concentrations of Cu in liver and Mo in urine were also estimated. 2. The effects of the three S sources on Cu and Mo metabolism were similar. Repletion of the plasma Cu pool was unaffected by Mo alone, reduced by S alone and totally inhibited by Mo+S. Plasma Mo was greatly increased by Mo supplements, slightly decreased by S supplements and unaffected by Mo and S supplements given together. 3. In Expt 3 the treatments were found to affect urinary Mo and plasma Mo in a similar manner; S prevented dietary Mo from increasing Mo excretion. The only group to show a significant repletion of the liver Cu pool was that given Mo alone. 4. Supplementation of the diet with organic S significantly reduced the within-treatment variation in plasma Cu and Mo. liver Cu and urinary Mo. 5. It is suggested that variations in dietary S and Mo within the normal range for herbage affect the Cu and Mo metabolism of the grazing animal, and that total S rather than inorganic S is the more useful measurement in the context of the Cu-Mo-S interrelationship.

Animal Nutritional Physiological Phenomena↗