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Biomedical subjects

N Falser

Publications and source records attributed to N Falser.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Papilloma of the larynx. Immunology (author's transl)].

Electron-microscopic and immunohistological studies show the cross-reactivity of an antigen in verruca plana, condyloma acuminatum and laryngeal papilloma. If this antigen is identical with papova virus or a tumor-performed antigen, cannot be distinguished definately. The fact that sera of patients bearing condylomata acuminata show strong antigen-antibody-reaction with tissue-sections of laryngeal papilloma by means of immunofluorescence microscopy, is discussed in a probably therapeutical point of view.

Antigens, Viral↗
PubMed1977

[Immunohistochemical and radioimmunological demonstration of alpha1-fetoprotein in nonmalignant changes of human gastric mucosa (author's transl)].

The occurrence of alpha1-fetoprotein in nonmalignant changes of the gastric mucosa was investigated by means of immunohistochemistry and radioimmunoassay. The investigations were performed in tissue sections, cytological imprint preparations as well as in homogenized tissue samples (obtained by gastroscopy). alpha1-fetoprotein could be demonstrated by immunohistochemistry in about 90% of the samples originating from the surroundings of gastric ulcer and the region of gastrojejunostomy after B II-resection. The RIA was positive in about 75% of the tissue samples, whereas from gastric juice only 40% of positive results could be obtained. No alpha1-fetoprotein-activity could be demonstrated in serum samples. These investigations indicate that alpha1-fetoprotein is not exclusively synthesized by embryonic or neoplastic tissues and also can be synthesized also by regenerating cell-systems. It may be supposed that this synthesis represents an unspecific answer to growth-stimulation.

Cell Division↗
PubMed1977

[Rare late complications following thorotrast arteriographs (author's transl)].

Hematemesis in a thorotrastosis patient with severe liver dystrophy led to a tentative diagnosis of portal hypertension. The possibility of portal hypertension was eliminated via angiography. The cause of the hematoemesis was multiple bleeding stomach ulcers. In spite of severe damage to the liver parenchyma, portal hypertension with thorotrastosis does not usually occur. This has been confirmed in the literature and by histologic investigations. In second thorotrastosis patient, the cause of pain and swelling was a sterile abscess formation in the area of the thorotrastoma.

Aged↗
PubMed1976

[Effect of long-term treatment with synthetic oestrogens on plasma lipids and arterial vessels in male rabbits (author's transl)].

The effects of long-term treatment with synthetic oestrogens (Retalon retard, Sanabo Ltd., Wien, 5 mg/kg i.m. at weekly intervals) were investigated in 12 male rabbits and compared with the data obtained in 9 saline-treated control animals. After 6 months of treatment the oestrogen group showed significantly higher plasma phospholipid (p less than 0.005) and cholesterol (p less than 0.01) concentrations than the control group. However, histological examination of various important arterial vessels (the aorta and the coronary, cerebral, limb and renal arteries) revealed no pathological changes indicative of premature atherosclerosis in either the oestrogen group or in the control group. It is concluded that long-term treatment with synthetic oestrogens does not result in a higher incidence of atherosclerosis in rabbits.

Animals↗
PubMed1976

Occurrence of alpha-1-fetoprotein in the mammary gland tissue of men with gynecomastia.

Immunohistochemical proof of A1FP production in the mammary gland of a man with gynecomastia is published here for the first time. The immunohistochemical proof of this fetal alpha-1-globulin in the intraductal epithelium of the mammary gland is described on the basis of the case history of a 25-year-old man with a metastasizing malignant teratoblastoma of the gonads. The question, to what extent A1FP-neosynthesis is characteristic for malignant tumors or whether it is a cellular response to specific, in this case hormonal growth stiumli of primary tumors, is also discussed.

Adult↗
PubMed1975

[Immunohistochemical studies on non neoplastic and neoplastic gastric mucosa. Determination of embryonic and specific antigens (author's transl)].

The distributions of acid alpha1-glycoprotein, alpha1-fetoprotein, beta-galactosidase and gastrin in gastric carcinoma and gastric ulcer as well as in the neighbourhood of these lesions were studied by means of immunohistochemical methods on imprint preparation. We could not find significant differences between gastric carcinoma and the nonneoplastic lesions, except for the acid alpha1-glycoprotein. The results of this first study indicate that the immunochemical and immunohistological assay of acid alpha1-glycoprotein might be of practical value in diagnosing malignant changes of gastric mucosa.

ABO Blood-Group System↗
PubMed1975

[Serological identification of carcinospecific antigens (and their significance as donor screening or for specific groups of diseases)].

Alpha-1-fetoprotein is an example of a circulating, measurable tumor product of diagnostic and therapeutic value. The involvement of its synthesis could be a result of a premalign cellular change in cell biochemistry. Contrary to the synthesis of trophic hormones in certain undifferentiated neoplasms, alpha-1-fetoprotein in hepatoma is specific for the organ origin of the tumor. Unlike the immunoglobulins in myeloma or the corticosteroids in adrenocortical tumors, it is a protein that normally can be synthetized in the fetus only. The purpose of the present paper is to discuss a new method for testing serum samples of blood donors being suspected of an alpha-1-protein by means of counterelectrophoresis. The diagnostic value is shown in a blood donor who could be singled out as a suspect of primary liver carcinoma only by means of serological testing.

Adult↗
PubMed1975

[Balanced parenteral nutrition following total pancreatectomy. (Metabolic data)].

The replacement of components of normal metabolism getting lost during operation is an important problem for the clinician. On the basis of a case of total pancreatectomy because of carcinoma of the pancreas this essential problem for the postoperative treatment is demonstrated. After control of the predominant metabolic parameters of the patient over a relatively long postoperative period, we want to formulate our conclusion as follows: In spite of the massive surgery we found only relatively small destruction of the patient's metabolic system. The evident variations in blood sugar level were probably caused by the often changing kinds of nutrition (the patient having been some weeks at home). As the most distinctive sign of a well performed therapy we regard the results of the daily weight control. In spite of the heavy physical stress over many months we could stabilize the patient's body weight after a short postoperative loss.

Aged↗