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Biomedical subjects

N Ferguson

Publications and source records attributed to N Ferguson.

8 recordsLinked to original sources
PubMed1996

Multiplicity of fibronectin-binding alpha V integrin receptors in colorectal cancer.

Current data from in vitro and in vivo animal models indicate that fibronectin-binding integrin receptors expressed by colon cancer cells may regulate tumour growth. While individual members of the beta 1 subfamily of integrins have now been clearly identified in colorectal cancer, little information exists with respect to the alpha V subfamily. In the present study we show that alpha V can associate with multiple and different beta subunits capable of binding fibronectin in this tumour type. This is likely to have functional implications for growth and spread of colorectal cancer.

Antigens, CD↗
PubMed1992

Sexuality in a natural population of bacteria--Bacillus subtilis challenges the clonal paradigm.

Reproduction by binary fission necessarily establishes a clonal genotypic structure in bacterial populations unless a high rate of genetic recombination opposes it. Several genetic properties were examined for a wild population of Bacillus subtilis in the Sonoran Desert of Arizona to assess the extent of recombination in a natural population. These properties included allozyme variation revealed by multilocus enzyme electrophoresis, phage and antibiotic resistance, and restriction fragment length polymorphism with Southern hybridization. Evidence of extensive genetic recombination was found along with evidence of modest clonal structure. Recombination must be frequent relative to binary fission in this population. This mixed population structure provides broader options for bacterial evolution than would a purely clonal structure.

Bacillus subtilis↗
PubMed1975

Pictographs and prereading skills.

This paper draws upon data collected in conjunction with the Schools Council (Great Britain) Research and Development Project in Compensatory Education to demonstrate that a picture reading task can provide a fairly good prediction of the later reading performance of 100 5-year-olds and that it is a sufficiently interesting clinical tool to merit further consideration from nursery and infant school teachers. The test's success seems to relate to its ability to measure differences in children's understanding of the nature and purpose of reading.

Child Development↗