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N Feuerstein

Publications and source records attributed to N Feuerstein.

42 records · Page 3Linked to original sources
PubMed1981

Leukotrienes C4 and D4 induce prostaglandin and thromboxane release from rat peritoneal macrophages.

The present study examined the effect of leukotrienes C4 and D4, the products of the 5'lipoxygenase pathway on prostaglandins and thromboxane release from rat peritoneal macrophages. Incubation of rat peritoneal macrophages with leukotrienes C4 and D4 enhanced the release of prostaglandin E2 (PGE2), 6-keto PGF1 alpha and thromboxane B2 (TxB2) in a dose-dependent manner. The increase of PGE2 was more pronounced than that of 6-keto-PGF1 alpha and TxB2. Lipopolysaccharide, a known stimulator of these cells elicited a similar pattern of increase of the arachidonate metabolites assayed. These results suggest that leukotrienes C4 and D4 are potential activators of macrophages. Since leukotrienes C4 and D4 are produced by these cells, it is suggested that endogenous leukotrienes may be involved in activation of macrophages.

Animals↗
PubMed1980

The effect of indomethacin on isoprenaline-induced renin secretion in the cat.

In vivo isoprenaline infusion (0.1 micrograms/kg.min)) into the renal artery of unilaterally nephrectomized cats elicited a 5-fold increase in plasma renin concentration (PRC). This increase was suppressed by concomitant administration of propranolol (0.3 mg/kg.min). Indomethacin (250 micrograms/kg.min) intrarenally infused prior to the administration of isoprenaline, abolished the isoprenaline-induced increase in PRC. It is suggested that prostaglandins mediate beta-adrenergic-activated renin release.

Animals↗
PubMed1980

The role of the renin-angiotensin system in mediation of adrenal catecholamine secretion in the cat induced by intrarenal beta-adrenergic stimulation.

Isoproterenol infusion (0.1 microgram/kg per min) into the renal artery of the cat induced an increase in plasma renin concentration (PRC) from 14.3 +/- 5.7 (mean +/- SE) ng angiotensin I/ml per hr to 56.8 +/- 7.7 after 70 minutes (P < 0.05) and an increase in catecholamine secretion rate from 38.7 +/- 6.0 ng/kg per 10 min to 180.0 +/- 40.0 after 70 minutes (P < 0.001). Intravenous infusion of the same dose of isoproterenol had no significant effect on adrenomedullary catecholamine secretion rate. Isoproterenol induced preferential norepinephrine release: the ratio of norepinephrine to epinephrine secretion changed from 11.5:23.7 during the control period to 130.0:40.1 70 minutes after the start of isoproterenol administration. Intrarenal infusion of propranolol (3.0 mg/kg per min) inhibited renal renin release and adrenal catecholamine secretion in response to intrarenal isoproterenol. Intravenous infusion (0.4 microgram/kg per min) of an angiotensin II antagonist [Sar1, Ileu8]angiotensin II abolished the catecholamine response to intrarenal isoproterenol infusion. It is suggested that intrarenal isoproterenol infusion stimulates renal renin release and angiotensin production which, in turn, stimulates a preferential secretion of adrenomedullary norepinephrine.

1-Sarcosine-8-Isoleucine Angiotensin II↗
PubMed1979

Endogenous prostaglandins modulate adrenal catecholamine secretion.

Adrenal catecholamine secretion induced by haemorrhage in the cat was increased by administration of indomethacin to intact or to bilaterally nephrectomized animals. Infusion of PGE2 (but not of PGF2 alpha) suppressed the increased catecholamine secretion caused by indomethacin.

Adrenal Glands↗