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Biomedical subjects

N Fiumara

Publications and source records attributed to N Fiumara.

8 recordsLinked to original sources

Ampicillin allergy presenting as secondary syphilis.

This article reports a case of ampicillin rash with oral and skin lesions, including lesions on the palms and the soles. The distribution of the lesions in a young, sexually active man was suggestive of secondary syphilis. The history, the nature of the delayed rash of ampicillin, and the treatment are reviewed.

Adult↗

Treatment with levamisole of recurrent herpes genitalis.

A double-blind study was carried out to investigate the possibility of therapeutic effect of levamisole on recurrent progenital herpes. One hundred and nine patients, including 53 females, entered the study, but only 75 completed. Levamisole, 50 mg three times daily for 3 days, was started at the first sign of recurrence. The study period consisted of 6 visits or 12 months, whichever came first. No statistical differences were observed between levamisole and placebo groups when comparing the duration of the lesion and the degree of pain, although less pain was observed among those on levamisole. The interval between attacks was increasingly prolonged in the levamisole-treated group, and reached a significant level at the sixth visit. However, analysis on the basis of mean cumulative number of days between attacks showed no significant differences throughout the study period. Because of occasional neutropenia and generalized urticaria, and because of the absence of clear-cut clinical improvement of statistical significance, levamisole was considered of limited benefit to patients with recurrent genital herpes infection.

Adult↗

Genital herpes: Treatment with methylene blue and light exposure.

Fifty-six patients with genital herpes were treated by photodynamic inactivation of herpesvirus by methylene blue (36 patients), proflavine (101 or neutral red (10). The first 35 patients were randomly selected for treatment with one of the three dyes. All the others were initially treated with methylene blue. The disease was temporarily eradicated in about 70% of instances by exposure of the lesions to light plus topically applied methylene blue, neutral red or proflavine. Relapses, however, were not prevented or appreciably reduced.

Acridines↗