Biomedical subjects
Publications and source records attributed to N Flores.
We report a case of right intrathoracic kidney associated with a complex somite malformation that comprised vertebral fusion and right intrathoracic supernumerary ribs. The interpretation of this association as a disease model of nature allows us to propose a unifying hypothesis on the pathogenesis of this form of renal dystopia.
We report here the construction and analysis of insertional mutations in each of the three genes of the gltBDF operon and the nucleotide sequence of the region downstream from gltD. Two open reading frames were identified, the first of which corresponds to gltF. The gltB and gltD genes code for the large and small subunits, respectively, of the enzyme glutamate synthase (GOGAT). gltF codes for a protein, with a molecular mass of 26,350 Da, which is required for Ntr induction. Histidase synthesis was determined as a measure of Ntr function. First, insertions in gltB, gltD or gltF all prevent Ntr induction. Second, complementation analysis indicates that high-level expression of both the gltD and gltF genes is required for the induction of the Ntr enzymes under nitrogen-limiting conditions, indicating that the phenotype of the gltB insertion probably results from polarity on gltD and gltF. Third, glutamate-dependent repression of the glt operon appears to be mediated by the product of the gltF gene. Thus, the gltBDF operon of Escherichia coli is involved in induction of the so-called Ntr enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis.
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In the context of a misleading diagnosis of paraurethral abscess, we report a case of unrecognized metastatic squamous cell carcinoma of the male urethra that mimicked a picture of paravertebral abscess with accompanying massive caval vein thrombosis. Fine needle aspiration cytology of both paravertebral abscess and urethral nodule allowed the diagnosis. This report calls the attention of clinicians to think of a malignant process in case of a paravertebral abscess. Fine needle aspiration cytology once more proves a useful tool in the diagnosis of unsuspected malignancies.
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Presentation of one case of a 61-year old male with a non-Hodgkin lymphoma, where a renal cell adenocarcinoma was unexpectedly discovered during and extension study. Review of the pathogenic significance of such association in the light of the various explicative hypothesis of this concurrence.
A case of focal Salmonella sp. urinary infection in an elderly diabetic patient is described herein. The therapeutic approach in this uncommon type of infection is discussed.
Clinico-pathological study of six patients with cerebral metastasis from vesical carcinoma with no prior administration of systemic chemotherapy. In two cases the symptoms of intracranial mass were the initial reason for infiltrant vesical carcinoma examination. Despite the rarity of such occurrence, the possibility of vesical tumours showing in such a way must be taken into account. The singularity of cerebral metastatic seeding throughout the natural history of a vesical neoplasia is analyzed. Also, a review is made of the factors hypothetically responsible for the increase of cerebral metastasis establishment following current chemotherapy.
Display of the clinico-pathological correlation of three cases of adenomatoid tumour (AT) of the male reproductive organs. From the anatomo-pathological point of view we observe the architectural patterns traditionally described, and discuss their controversial mesothelial origin. From the clinical point of view we highlight the benignancy of the process, often underdiagnosed, as well as its association to post-inflammatory hydrocele in one case. Such coincidence could favour the assumption that inflammation plays a decisive role on the production mechanism.
Presentation of a new case of synchronic concurrence of renal adenocarcinoma and papillar carcinoma of renal pelvis on the same kidney. The origin of this double malignant renal tumour remains unknown, although several hypothesis have been raised. We believe that coexistence of both tumours is more than casual and we would underscore the morphogenetic interpretation of such coincidence.
We describe a case of metastatic nephroblastoma presenting as renal rupture. Histology was "favorable". Lung metastases were discovered early during follow-up. Radiotherapy and surgical excision were therefore combined with intensive chemotherapy. Ten years later, the patient is symptom-free.
A cellular variant of congenital mesoblastic nephroma (CMN) occurring in a newborn is presented. Coincidental findings were congenital hypertrophic pyloric stenosis (CHPS) and nephrocalcinotic hypercalcemia that reverted after nephrectomy. As of the day of writing, this multiple association has not been reported. The authors believe that both CMN and CHPS could be interpreted as fibroblastic proliferative-related entities. Transient hypercalcemia seems to be a paraneoplastic phenomenon.
A 61-year-old man presented with macroscopic haematuria. Infiltrating transitional cell carcinoma of the urinary bladder was diagnosed after transurethral resection, and he was treated first with three doses of cisplatinum (100 mg/m2 at three week intervals) and then by radical cystectomy. Eleven months later he complained of progressive diplopia, which was found on computed tomography to be caused by a retro-orbital metastatic mass. There was no evidence of a space occupying lesion in the brain or of other metastases. The patient died four weeks later and permission for necropsy was refused. Despite the fact that carcinoma of the urinary bladder rarely metastasis in this way, urologists should be aware that it can happen.
The autopsy finding of congenital mesoblastic nephroma in a stillborn hydropic fetus is reported. We discuss the pathogenetic relation of both entities and summarize the optimal therapeutic attitude to follow in order to prevent this misfortunate outcome.
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A case of renal adenocarcinoma arising in a 18 year-old boy is reported. This is a rare entity in childhood and adolescence that displays a similar histology to the adult form. The recent literature on its clinical and pathological features is reviewed. We conclude that, despite its rarity, adenocarcinomas must be included in the differential diagnosis of solid renal masses in early life.
We present a case of urinary bladder carcinoma in a child aged 13 that followed a benign course. This confirms the idea that epithelial bladder cancer in children pursues, a much less aggressive behaviour than in the adult, possibly on the basis of its well-differentiated nature. Despite the rarity of the lesion, it should not be overlooked in the differential diagnosis of haematuria in children.