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Biomedical subjects

N François

Publications and source records attributed to N François.

At least 19 recordsLinked to original sources
PubMed2006

Multilocus sequence typing reveals intrafamilial transmission and microevolutions of Candida albicans isolates from the human digestive tract.

Candida albicans is a human commensal that is also responsible for superficial and systemic infections. Little is known about the carriage of C. albicans in the digestive tract and the genome dynamics that occur during commensalisms of this diploid species. The aim of this study was to evaluate the prevalence, diversity, and genetic relationships among C. albicans isolates recovered during natural colonization of the digestive tract of humans, with emphasis on Crohn's disease patients who produce anti-yeast antibodies and may have altered Candida sp. carriage. Candida sp. isolates were recovered from 234 subjects within 25 families with multiple cases of Crohn's disease and 10 control families, sampled at the oral and fecal sites. Prevalences of Candida sp. and C. albicans carriage were 53.4% and 46.5%, respectively, indicating frequent commensal carriage. No differences in prevalence of carriage could be observed between Crohn's disease patients and healthy subjects. Multilocus sequence typing (MLST) of C. albicans isolates revealed frequent colonization of a subject or several members of the same family by genetically indistinguishable or genetically close isolates. These latter isolates differed by loss-of-heterozygosity events at one or several of the MLST loci. These loss-of-heterozygosity events could be due to either chromosome loss followed by duplication or large mitotic recombination events between complementary chromosomes. This study was the first to jointly assess commensal carriage of C. albicans, intrafamilial transmission, and microevolution. The high frequency of each of these events suggests that the digestive tract provides an important and natural niche for microevolutions of diploid C. albicans through the loss of heterozygosity.

Bacterial Typing Techniques↗
PubMed2005

[Mechanisms and treatment of psoriasis].

Psoriasis is a common dermatosis that affects 3-5% of the European population. Current treatments offer considerable clinical benefits, but their use is limited due to tolerance problems. Recent years have seen the development of new treatments, used separately or in combination to improve the chronic lesions caused by this disease. T cells play an important role in the pathogenesis of psoriasis. Various techniques target the T cells and the immunological mechanisms involved in their activation. In 2005, treatment of psoriasis is directed essentially towards immunological pathways.

Anti-Inflammatory Agents↗
PubMed2005

[Management of reproduction disorders in spinal cord injured adolescents].

Adolescence is a period of research of sexual identity. How does a teenager build himself when a paraplegic or quadriplegic? How can the team of nursing staff help him? First we shall study the erection and the sexual relations and secondly we shall study the procreation issue. It is necessary to have early concrete information really suitable for a neurologic definition of a spinal cord injury and to conserve sperm before having complications of urinary infections. We inform 24 paraplegic or tetraplegic teenagers at the CMPA in Neufmoutiers and the CECOS at the Cochin Hospital in Paris.

Adolescent↗
PubMed2000

Synthesis and antifungal activity of a ferrocene-fluconazole analogue.

A novel ferrocene fluconazole analogue was synthesized and its antifungal properties investigated against yeast strains of medical importance, including those intrinsically resistant to fluconazole. In vitro tests revealed a slight increase in fungal growth and a reversal of the effect of fluconazole at minimal inhibitory concentrations.

Antifungal Agents↗
PubMed1995

[Genital sexual and procreation disorders in patients with spinal cord injuries].

The first part of this report discusses techniques contributing to improved sexual relations in couples where either partner is paraplegic. The advantages and disadvantages of these techniques are described, in particular for intracavernous injections of vasoactive products. The second part considers procreative assistance for couples where the male is paraplegic, using mechanical, chemical and more recently surgical techniques. Surgery involves puncture of the ductus deferens. Significant experimental progress in medically assisted precreation is contributing to improved results. The importance of the psychological and emotional context must not be forgotten, as well as prevention of complications such as urological infections.

Female↗
PubMed1990

[Post-traumatic hemobilia caused by arteriobiliary fistula. A case report and review of the literature].

One new case of post-traumatic hematobilia due to an arteriobilary fistula is reported. This etiology is relatively rare, and its diagnosis is sometimes difficult if the three signs: pain, bleeding and jaundice are not observed. The most effective paraclinical examination still is selective arteriogrpahy, which makes the diagnosis possible, accurately locates the fistula and sometimes allows hyperselective embolization, as it did in this case. The use of embolization for the treatment of post-traumatic hematobilia due to an arteriobiliary fistula reduces operative mortality for this disease, which still has a poor prognosis.

Adult↗
PubMed1983

[Evaluation of fertility in paraplegic men].

The characteristics of the semen of the paraplegic men were studied on 57 examinations of the semen of 21 patients. The technic of ejaculation stimulation had an influence on the volume, which was much more important with vibromassage, and the spermatozoa mobility, which was lower with electrostimulation. The comparison with the semen of a reference population of fertile and infertile men reveals that the diminution of the volume, of the normal forms and specially of the mobility are the main semen characteristics of the paraplegic. All the parameters have higher values in the semen of the fertile paraplegic than in these of the infertile paraplegic.

Adolescent↗
PubMed1977

Scanning electron microscopy of ejaculated baboon (Papio anubis) spermatozoon.

Scanning electron microscopy has been used in order to provide the morphological study including comparative measurements of the main parts of the Baboon spermatozoon. If the dimensions of the head and the mid-piece are fairly close to the human spermatozoon, the Baboon spermatozoon is practically twice as long as the human one. In the Baboon spermatozoon, the head appears smooth with only a light ransversal furrow at the level of its posterior third, which probably marks the limit of the posterior border of the equatorial segment. The mid-piece, a conical trunk, is larger in its anterior part than at the level of its posterior extremity. The end-piece appears very short as compared with the total length of the sperm cell. The technical modalities of the preparation and the possibility of artifacts are briefly discussed.

Animals↗
PubMed1976

Expression of genetic markers of erythrocyte immunoglobulin G autoantibodies in autoimmune hemolytic anemia.

The Gm allotype constitution of the autoantibody molecules and the serum Gm phenotypes were determined in 19 patients with autiommune hemolytic anemia of IgG type. The results showed that the known heterogeneity of the antierythrocyte autoantibodies in this disease concerns not only the immunoglobulin class and the isotypic subclass, but also the genetic markers of these molecules. Evidence was obtained that the anomalous production of antierythrocyte autoantibodies is polyclonal, that thse autoantibodies belong mainly to the IgG1 isotypic subclass, and that they have a preference for the Gm(1) allotype. In addition, certain of the findings point to a preferential expression of the Gm(1,21) haplotype.

Anemia, Hemolytic, Autoimmune↗