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Biomedical subjects

N Franco

Publications and source records attributed to N Franco.

11 recordsLinked to original sources
PubMed1991

A new family with chorioretinal dystrophy, spinocerebellar ataxia and hypogonadotropic hypogonadism (Boucher-Neuhäuser syndrome).

A family is described in which two brothers have spinocerebellar ataxia, hypogonadotropic hypogonadism and chorioretinal dystrophy. This report provides further evidence to support the previous suggestion that this triad of manifestations represents a specific single-gene disorder, designated Boucher-Neuhäuser syndrome. Analysis of affected individuals shows that neurological signs usually develop during adolescence or young adulthood (range: early childhood-fourth decade) and are slowly progressive or non-progressive, whereas ophthalmologic manifestations have an age of onset which varies from the first to the sixth decade of life and a pronounced variability in progression.

Adult↗
PubMed1984

[Nickel sensitivity in an atopic patient].

A case of atopic dermatitis with it's classics signs in face and extremities, with an eight years evolution is reported. It was treated with corticoids (local and systemic) with no favorable results. In the allergic investigation it was found a sensibilization to nickel. She was cured by eliminating the nickel from her diet and from the objects in contact. Clinic and etiopathogenic considerations between allergic dermatitis by contact to nickel in the atopic and the non-atopic are made.

Adult↗
PubMed1982

Autonomic neuropathy in the skin: a histological study of the sympathetic nerve fibres in diabetic anhidrosis.

In diabetics with the anhidrotic syndrome, autonomic nerve fibres were studied in skin biopsies using argentic techniques and light microscopy. The Minor test was used to differentiate normal from anhidrotic skin areas. In the anhidrotic areas, histology of the nerve fibres showed beading, spindle-shaped thickening and fragmentation adjacent to the sweat glands. These changes were similar to those observed in two patients who had previously undergone lumbar sympathectomy. No abnormalities of the sympathetic nerve endings could be found in biopsies taken from normal areas of the forearm of the same patients. We conclude that the diabetic anhidrotic syndrome, a form of diabetic autonomic neuropathy, is due to a lesion of the sympathetic nerve supply to the skin. It is suggested that the Minor test or a skin biopsy should be performed in diabetic patients who are being considered for surgical sympathectomy.

Adrenergic Fibers↗
PubMed1982

[Retarded bullous dermographism].

A case of what we denominate Bullous Delayed Dermographism in a woman who had neither allergic nor urticarial antecedents is registered. We comment the features of the lesions which appeared after a period of 4 to 12 hs. This lesions appeared by friction or percussion. We describe the existence of an endocrine and psychological predisposition mechanism and the non specificity of the histopathological characters. The nonexistence of bibliographical antecedents of the illness is noted. Also its difference with bullous and pressure urticaria. This differentiation is based on clinical features, and the nonexistence of allergic antecedents and urticarial lesions. Also on the existence of friction mechanism different to the simple pressure and the nonexistence of immunoglobulins in the subepidermal blister.

Female↗
PubMed1976

[Ultrastructural study of the follicular cells of the adenohypophysis of the chicken].

As in other species, a network of follicular cells linked together by functional complexes can be observed by electron microscopy in the adenohypophysis of the chick. No secretory granules are seen in the follicular cells. They are connected with each other by thin and long processes inserted between the glandular cells and the perivascular spaces. They limit, by their follicular pole, submicroscopic cavities of irregular size and shape. They are empty or occupied by a material of variable density. These cells exist very precociously in the embryo but their characteristic organisation to form a network is observed only on the 16th day of incubation. Our experimental study made it possible to evoke, as a number of other authors, that they play a role in the functions of support, exchange, transport of secretory material or phagocytosis.

Animals↗
PubMed1975

[Immunocytochemical study of corticotropic cells in the adenohypophysis of the chick embryo].

Corticotrophin cells of the pituitary have been studied immunocytologically with I.S. anti-A.C.T.H. (1-24) and I.S. anti-A.C.T.H. (17-39). These sera show differentiated cells as soon as the 8th of incubation. These cells remain located within the anterior part of the adenohypophysis. They are not "revelated" by I.S. anti-beta-M.S.H. and I.S. anti-beta-LPH.

Adrenocorticotropic Hormone↗