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N Freudenberg

Publications and source records attributed to N Freudenberg.

137 records · Page 8Linked to original sources
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AIDS and health education.

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Acquired Immunodeficiency Syndrome↗
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[An immunohistochemical study of the steroid hormone receptors in endometrial hyperplasia].

AIM: Evaluation of the estrogen and progesterone receptors (ER and PR) in different degrees of endometrial hyperplasias. METHODS: 10 cases of each degree of endometrial hyperplasia (simple, complex and atypical) were analyzed using the avidin-biotin-peroxidase technique and monoclonal antibodies applied to formalin-fixed, paraffin-embedded tissue. RESULTS: We found similar, high level of both ER and PR in simple and complex hyperplasias and a significant decrease of these in atypical hyperplasia. CONCLUSIONS: Endometrial hyperplasias develop in a setting of estrogen excess. This explains the high level of endometrial receptors and the response to progesterone in typical hyperplasia. In atypical hyperplasia, the decrease of steroid receptors results in a low sensibility of this lesion to progestative therapy, but there are cases with high receptor levels which could have a chance for hormonal therapy.

Biomarkers↗
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[p53 and steroid receptors support double endometrial carcinogenesis].

AIM: This study investigated the p53 positivity correlated with the receptor status, in different grades and stages of endometrial carcinoma. METHODS: The study included 88 endometrioid-type carcinomas and 5 non-endometrioid-type carcinomas. Paraffin sections were used for the ordinary histological diagnosis and for immunohistochemical diagnosis by avidin-biotin-peroxidase technique. RESULTS: p53 positivity was identified in 10 endometrioid-type carcinomas (11.4%) and 3 non-endometrioid type carcinomas (60%). Most of the p53 positive cases were receptor negative and observed in advanced stages and histological grades. No associated endometrial hyperplasia was p53 positive, while a positive intraepithelial non-endometrioid carcinoma was identified. CONCLUSIONS: p53 positivity is most frequently identified in non-endometrioid type, receptor negative adenocarcinomas, even in a precursor lesion as it is intraepithelial carcinoma, while in endometrioid, receptor positive carcinomas it appear in late stages of development, never being identified in precursor lesions.

Carcinoma↗
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Immunocytochemical analysis of ascitic fluid due to cirrhosis. A contribution to understanding the origin of markedly atypical cells.

In some cases of ascitic fluid due to cirrhosis, benign mesothelial clusters may be observed, accompanied by markedly atypical cells that have been proposed to be abnormal macrophages, mesothelial cells or necrotic cells of hepatic origin. The aim of this study was to determine the origin of these cells with the use of a panel of monoclonal antibodies (MAbs) against cell surface antigens. Furthermore, the lymphocyte subpopulations were analyzed for a possible correlation with the presence of abnormal cells. Markedly atypical cells were found in 4 of 12 cases. They showed no phagocytosis of latex particles and were negative for MAbs My4 (CD14), HLE-1 (CD45), Leu M1 (CD15), CEA 3-13 and HEA-125. They reacted positively with BMA-120 and HLA-1. This staining pattern demonstrated the mesothelial origin of the markedly atypical cells. The profile of the lymphocyte subpopulations in the cases with markedly atypical cells was not different from the other cases. We propose that these cells are abortive cluster formations of mesothelial cells.

Adult↗
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An evaluation of community-based HIV services for women in New York State.

The proportion of women in New York State diagnosed with acquired immune deficiency syndrome (AIDS) is increasing dramatically. In 1987, only 12% of cumulative AIDS cases in New York were among women; by 1993, 26% of new cases of AIDS were. This evaluation describes community-based HIV programs that provide services to women in New York State and are funded by the State Department of Health's AIDS Institute. The evaluation assesses the success different programs have had in reaching and engaging women. It also describes the problems organizations face in serving their target populations. Four sets of data were collected and analyzed to assess the care being received by female clients. Programs appear to be reaching women who are human immunodeficiency virus (HIV) positive or at high risk of HIV infection, and once engaged, female clients find the services helpful. However, agencies report difficulties in finding and using the strategies that are most effective with women. Agencies appear to do a better job of addressing their female clients' economic needs than those related to gender, such as reproductive health care, family services, and access to clinical trials.

Adolescent↗
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Gender differences in attitudes and use of condom availability programs among sexually active students in New York City public high schools.

In 1991, the New York City Board of Education expanded HIV/AIDS education to include condom availability in public high schools. A three-year study was initiated to assess the program's impact on student risk behavior, the schools' social environments, and patterns of communication about HIV/AIDS and condoms among students, their parents and teachers in 12 randomly selected New York City high schools. Findings on gender differences in both attitudes and use of the program among sexually active students are reported here. Sexually active girls' attitudes toward using condoms and the condom availability program were more positive than those of sexually active boys, yet boys were more likely to have used the program. Girls reported embarrassment and confidentiality concerns as the main deterrents to using the program. Data suggest that schools need to examine the address gender-specific attitudes that contribute to reluctance to use the program among sexually active girls.

Adolescent↗