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N Fujimura

Publications and source records attributed to N Fujimura.

86 records · Page 5Linked to original sources
PubMed1978

Comparative controlled clinical trial of pivmecillinam and nalidixic acid in patients with acute simple urinary tract infections.

We performed a controlled double-blind clinical study with PMPC to investigate its therapeutic usefulness in acute simple cystitis in comparison with NA, with the results as follows: 1. In both treatment groups, PMPC proved to be remarkably more active (MIC) than NA against the bacterial isolates tested in vitro. 2. PMPC, administered in dosis (200 mg per day) one-tenth those of NA (2,000 mg per day), produced a greater improvement (therapeutic effects) than NA. 3. Side-effects were apparently less frequent with PMPC, as compared to NA. The results indicate a remarkable usefulness of PMPC in the treatment of acute simple cystitis.

Acute Disease↗
PubMed1977

[The investigation of the absorption of 99mTc gamma-rays by bone and soft tissue (author's transl)].

UNLABELLED: Recently, the scintigram with 99mTc-labeled compounds has been routine procedure, because of it's ideal physical characteristics. The short physical half life of six hours, the absence of beta emission, and the gamma rays of 140 keV permit the administration of large amount of radioactivity. For scintigram of deep or large organ, the absorption of 99mTc gamma-rays by bone and soft tissue should not be negligible. For example, bone scintigram with 99mTc-phosphorous compounds shows different pictures depending upon the anterior and the posterior views, because of it's rather lower energy. Therefore, the linear attenuation coefficient and the half value layer of bone and soft tissue were measured with 99mTc gamma-rays and others (197Hg, 203Hg, 131I, 198Au, 85Sr). RESULTS: 1) The linear attenuation coefficient of 99mTc gamma-rays was: bone -0.240 cm-1, acrylite -0.173 cm-1, Mix D -0.155 cm-1. 2) The half value layer of 99mTc gamma-rays was: bone -2.89 cm, acrylite -3.98 cm, Mix D -4.47 cm. It was concluded that the lower photon energy of 99mTc was influenced by bone and soft tissue, but it appeared to be most suitable for the present imaging devices. Therefore, pictures of multiple views are necessary in case of the scintigram was 99mTc-labeled compounds.

Absorption↗
PubMed1976

Clinical experience with gentamicin in complicated urinary tract infections (author's transl).

Gentamicin 40 mg was intramuscularly admininistered two times daily to 15 patients with complicated urinary tract infections. The results are as follows 1. The clinical efficacy of gentamicin was excellent in 12 cases (80.0%), good in 2 cases (13.3%) and null in 1 case (6.7%). The effective rate was 93.3%. 2. Bacteria disappeared in 16 strains (84.2%), colonized in 3 strains (15.8%) out of 19 isolates. 3. BUN, GOT and GPT values were determined before and after GM administration, and no significant abnormal finding attributable to GM was observed in this clinical study.

Adolescent↗
PubMedDate not supplied

The effects of midazolam and ketamine on D-tubocurarine-induced twitch depression in septic rat diaphragm.

The aim of this study was to elucidate the effects of midazolam and ketamine on neuromuscular blockade induced by non-depolarizing muscle relaxants (NDMRs) under the condition of sepsis induced by panperitonitis. A CLP operation (laparotomy, cecal ligation, and puncture of the cecum; septic group) or sham laparotomy (sham group) was performed on rats under O2-isoflurane anesthesia. At 18 hours after the operation, isometric twitch tensions of rat nerve-hemidiaphragm preparations elicited by indirect or direct stimulation at 0.1 Hz were measured. Midazolam enhanced the dTc (1 microM)-induced twitch depression (p < 0.05) at a high concentration (10 microM) in the septic group but not in the sham group. Ketamine enhanced the dTc (1 microM)-induced twitch depression in the sham group (p < 0.01) but not in the septic group. Midazolam and ketamine had no effect on directly elicited twitch tensions in either group. The results indicate that sepsis facilitates the midazolam-induced enhancement of the neuromuscular blocking effect of dTc but, conversely, inhibits the ketamine-induced enhancement. Sepsis elicits manifold alterations in the influence of intravenous anesthetics and sedatives on NDMR-induced neuromuscular blockade.

Anesthetics, Dissociative↗
PubMedDate not supplied

Clinical evaluation of hepatic artery embolization: comparison between Gelfoam and Lipiodol with anticancer agent.

Transcatheter embolization of the hepatic artery for hepatomas was performed with the use of Gelfoam and Lipiodol-ADM in 98 patients (Gelfoam 63 patients; Lipiodol-ADM 35 patients). The cumulative one-year survival rate was 52.9% for the Gelfoam group and 28% for the Lipiodol-ADM group. Response to hepatic embolization was most remarkable in the nodular type; CR was obtained in five patients and PR in 31 patients (response rate: CR + PR = 57.1%) in the Gelfoam group, with no CR and six PRs (response rate, 17.6%) in the Lipiodol-ADM group. Alfa-feto protein (AFP) decrease of more than 50% was observed in 78.1% of the Gelfoam group and 40% of the Lipiodol-ADM group. The side effects were transient and controlled with conservative treatment. Gelfoam seemed to be more effective in the treatment of hepatoma, but the damage to normal tissue was more severe with this embolic material.

Aged↗