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Biomedical subjects

N G Andreev

Publications and source records attributed to N G Andreev.

8 recordsLinked to original sources
PubMed2001

[Use of ednit in the treatment of portal hypertension in patients with chronic hepatitis and liver cirrhosis].

AIM: To study ednit (ACE inhibitor) effectiveness in the treatment of portal hypertension in patients with chronic hepatitis (CH) and hepatic cirrhosis (HC). MATERIAL AND METHODS: The examination of 87 patients with active CH and 54 patients with HC at the preascytic stage included two-dimentional ultrasonic scanning of the abdominal organs with doppler fluometry of the vessels in the territory of the portal vein, tetrapolar rheohepatography, ultrasound investigation, angiography of the abdominal vessels. The patients received combined therapy with ednit in a dose 5 mg twice a day for at least 5 weeks. RESULTS: Patients with active CH and HC having portal hypertension treated with adjuvant ednit in the above dose achieved marked clinicobiochemical remission quicker, portal-hepatic circulation improved. CONCLUSION: The addition of ednit to therapy of active CH and HC with portal hypertension is effective as it lowers total peripheral vascular resistance which eventually results in a fall of pressure in the territory of the portal vein and improvement of hepatic circulation. The highest effect is reached in administration of 5 mg twice for 24 hours.

Adolescent↗
PubMed2000

[24-hour monitoring of gastric juice pH in assessment of anti-ulcer treatment].

AIM: Comparison of various schemes of three-component eradication of duodenal ulcer (DU) using 24-h monitoring of gastric juice pH. MATERIALS AND METHODS: 62 DU patients in aggravation period have undergone 24-h monitoring of gastric juice pH and esophagogastroduodenoscopy with biopsy and H.pylori test of the treatment beginning and end. Patients of group 1 (n = 28) received ranitidin, metronidazole and amoxicillin while patients of group 2 (n = 34) took quamatel, metronidazole and amoxicillin. RESULTS: 24-h monitoring of pH of the gastric juice demonstrated that three-component therapy consisting of quamatel (20 mg/day, metronidazole (500 mg 4 times a day), amoxicillin (750 mg 3 times a day) maintains the level of intragastric acidity optimal for quick scarring of duodenal ulcer defect and led to eradication of H.pylori in 91.2% of cases. CONCLUSION: 24-h monitoring of gastric juice pH is a significant method of assessment of antiulcer treatment efficacy.

Adult↗
PubMed1991

[Drug therapy of pulmonary and portal hypertension in liver cirrhosis].

Detailed examination of hemodynamics in patients with portal and pulmonary hypertension was performed upon acute drug tests and course administration of nitrosorbide++, corinfar and propranolol. Ultrasound and rheography investigations were employed to elucidate the relations between portal and pulmonary hypertension in cirrhosis patients. Criteria of early diagnosis are discussed. Nitrosorbide++ produced positive effect on hepatic blood flow, corinfar improved pulmonary hemodynamics in lack of its influence on hepatic blood flow, while propranolol resulted in the drop of both portal and pulmonary hypertension, normalization of general hemodynamics.

Adult↗
PubMed1991

[Liver function in biliary tract dyskinesia].

The authors analyze data obtained in a complex clinico-instrumental study of the functional activity of the liver, portal and hepatic blood flow in 77 patients with different forms of dyskinesias of the biliary tract. Obtained data evidence in these patients development (against the background of cholestasis) functional insufficiency of the liver and involvement of its parenchyma associated with a moderate pressure increase in the portal vein, reduction of the hepatic blood flow intensity, increase of its lability that may be a proof of development (in patients with functional bile secretion disorders) of chronic diffuse inflammatory process in the liver with subsequent appearance of clinically clear portal hypertension.

Adolescent↗