PubMed Health⌕ Search

Biomedical subjects

N G Bychkova

Publications and source records attributed to N G Bychkova.

At least 19 recordsLinked to original sources
PubMed2005

[Role of enteral feeding mixture based on soy in correction of immune status of patients with burn wounds].

The authors have studied the immune status of patients with burn wounds, which had early received to their complex therapy of burn disease an additional enteral feeding based on soy suspension. All populations of immunocompetent cells have been revealed to be activated, especially T-helper lymphocytes taking part in reparative processes, antibody production, synthesis of anti-inflammatory cytokines, thus contributing to regenerative processes taking place in burn wounds, speeding patients' recovering.

Adult↗
PubMed1994

[The assessment of the local immune reaction of the mucosa of the large intestine in patients with nonspecific ulcerative colitis].

The article presents data on the features of local immune reaction in lamina propria of colonic mucosa in patients with severe unspecific ulcerous colitis. Identification of immunocompetent cells with monoclonal antibodies, considered the most effective method to date, was used in the study. Number of immunocompetent cells in lamina propria of colonic mucosa was established to be significantly higher in patients with severe UUC as compared to that of the control group, subpopulations of B-lymphocytes prevailing. Production of all immunoglobulins, especially of IgG, was increased. This evidences sharp activation of local immune reaction and attempt of the body to strengthen both first and second lines of immune protection in colonic mucosa.

Antibody Formation↗
PubMed1993

[An evaluation of the efficacy of different methods for identifying peripheral blood T- and B-lymphocytes in patients with nonspecific ulcerative colitis].

Rosette-forming with sheep's erythrocytes (EAC-RF) and monoclonal antibodies (MCA) were used for account of cell populations and subpopulations in patients with ulcerative colitis and Crohn's disease. It was established that MCA technique does increase accuracy of quantitative determination of immunocompetent cells in such patients but on the whole EAC-RF which is at present more accessible method can be considered quite acceptable for estimation of immune reactivity in nonspecific inflammatory diseases of the colon.

Antibodies, Monoclonal↗
PubMed1993

[Drug and non-drug immunocorrection in peptic ulcer].

Drug immunocorrection and microwave resonance therapy allowed to normalize the immune status in 93% of patients with ulcer disease. This allowed to achieve clinico-endoscopic remission in 82%, reduce scarring time on the average by 6-7 days and to reduce markedly the recurrence frequency.

Acupuncture Points↗
PubMed1992

[Differentiated immunocorrective therapy in nonspecific ulcerative colitis].

A comparative study of the clinico-immunological efficacy of steroid hormones and thymus drugs in 50 patients with unspecific ulcerative colitis of different activity grades revealed that their efficacy was not similar at different phases of the disease and depended on the activity of the inflammatory process. Corticosteroids were more effective in inflammatory-destructive changes in the mucosa of the large intestine while in mild inflammation with prevalence of ulcerative-reparative processes, immunomodulators (thymalin) are preferred.

Adjuvants, Immunologic↗
PubMed1992

[Changes in the trace element content of the blood in chronic hepatitis].

Trace elements were examined spectrophotometrically in 45 patients with chronic hepatitis (persisting--31; chronic--14). Lead and cadmium showed a significant increase both in the healthy and hepatitis patients. A reduction of zinc and increase of copper was found in patients with chronic hepatitis. Changes in the content of microelements depended on the severity of the disease.

Adult↗
PubMed1991

[The T- and B-immunity systems in patients with digestive organ diseases and exposure to internal radiation].

Results are reported of an immunological examination of 534 patients with digestive diseases and 130 healthy persons. 282 patients subjected to radiation effects showed a marked and persistent T-lymphocytopenia, B-lymphocytosis, reduction of the content of T-helpers, T-suppressors, dysimmunoglobulinemia characterized by reduction of IgG content and excessive IgA secretion. These changes were observed during the period of exacerbation and remission requiring the use of immunocorrective agents.

Accidents↗
PubMed1991

[The characteristics of the clinical course of digestive organ diseases in persons subjected to ionizing radiation exposure resulting from the accident at the Chernobyl Atomic Electric Power Station].

Results of a study of 1905 persons are reported. Of them 1775 showed diseases of the digestive organs. Among them were were 275 who were subjected to the effect of ionizing radiation. In these 275 patients the most frequent pathology were erosive lesions of the gastric and duodenal mucosa, gastroesophageal reflux, esophagitis. There was a dependence of the onset of the disease and stay in the disaster Zone. The disease was accompanied by a stable T-cellular immunodeficiency that exacerbated the course of the disease. It is recommended to include immunocorrectors in the complex therapy of these diseases.

Accidents↗
PubMed1990

[Effectiveness of immunostimulants in nonspecific ulcerative colitis].

Clinical and immunologic efficacies of some immunostimulants (levamisole, sodium nucleinate, thymic preparations) included in therapeutic schemes in nonspecific ulcerous colitis both separately and in various combinations were under study. The efficacy of these stimulants was found to depend on the disease severity and proved to be the highest in the light course. Thymalin and sodium nucleinate showed the highest clinical and immunologic efficacies, particularly if used together. Levamisole administration was associated with frequent side effects and had no essential advantages over basic therapy. This permits a conclusion that immunostimulants are pathogenetically validated in therapy of ulcerous colitis, for they result in reduction or elimination of immunity insufficiency and their administration leads to a positive clinical effect in the majority of cases.

Adjuvants, Immunologic↗
PubMed1990

[The metabolic and phagocytic activities of the neutrophilic granulocytes in patients with nonspecific ulcerative colitis nd Crohn's disease].

Immune homeostasis is of importance in the pathogenesis of unspecific inflammatory diseases of the colon. The authors studied the state of unspecific resistance of patients with unspecific ulcerative colitis (UUC) and Crohn's disease (KD); 27 with UUC and 21 KD patients with chronic relapsing forms of the disease were examined. Patients in the acute form of the disease showed an activation of the metabolic processes in the neutrophil granulocytes that was more pronounced in UUC and a reduction of the phagocytic activity in KD. During the period of early remission these values were practically normal evidencing the prognostic value of factors of unspecific defense in unspecific inflammatory diseases of the intestine.

Adolescent↗