Biomedical subjects
Publications and source records attributed to N G Dedukh.
Physical and technological parameters of carfecillin powder and carfecillin with auxiliary substances in the form of the powder mixture and granulate were studied comparatively. Possible preparation of carfecillin capsules characterized by high levels of the antibiotic dissolution was shown.
A procedure for dry granulation of antibiotics consisting in dry compacting of a powder-like composition followed by its grinding to granules was developed. The advantages of dicloxacyllin capsules manufactured by dry granulation over the capsules manufactured by moist granulation are shown with respect to the content of the light absorbing admixtures during the capsule manufacture and storage. The conditions for estimation of the antibiotic dissolution from the capsule were developed with the use of a "Rotating Basket" apparatus. Comparative evaluation of disintegration and dissolution of the capsules prepared by dry or moist granulation showed practical equivalence of both types of the capsules with respect to these characteristics.
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