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Biomedical subjects

N G Heselson

Publications and source records attributed to N G Heselson.

14 recordsLinked to original sources
PubMed1992

Case report 720. Multicentric mixed tumor of bone with pulmonary involvement.

A man presented with a mass in the left first metacarpal bone. Later, his chest radiograph showed extensive, bilateral, rounded opacities in both lungs with enlarged hilar lymph nodes, and he developed expanding lesions in the left radius, ulna, and metacarpal bones. The pulmonary lesions were treated with radiotherapy and cytotoxic agents, and the tumor mass in the first metacarpal was debulked. All biopsies showed similar features of a mixed tumor (pleomorphic adenoma) with metastatic or embolic pulmonary involvement; ultrastructural and immunocytochemical investigations supported this unique diagnosis. The patient remains well 15 years after the initial diagnosis. It is possible that the myoepithelial elements in this case had been displaced intraosseously during development. We are not aware of a similar case in the literature.

Adult↗
PubMed1989

Semilunar osteoblastic metastases in breast carcinoma. A new radiological sign.

Forty-seven cases of osteoblastic skeletal metastases were examined, of which 26 were from primary carcinoma of the breast. In two of these cases the metastases were of an unusual semicircular configuration. In each case the patient survived for at least four years after the discovery of metastases. This appearance may represent a better form of host response to metastatic disease.

Bone Neoplasms↗
PubMed1989

Spondylolysis of the axis. A case report and review of the literature.

Bilateral congenital defects in the pedicles of the second cervical vertebra were noted on conventional X-rays and tomography of a 42-year-old male. He had been assaulted after which he suffered upper neck and occipital pain. Subsequent CT scanning demonstrated the incomplete nature of the axis defects. This is felt to be important in prognosticating the likelihood of spondylolisthesis formation and counselling the patient with regard to acceptable future physical activity. The role of CT examination for this purpose has not been stressed before. The importance of differentiation from old trauma is emphasized.

Adult↗
PubMed1988

Chronic atlanto-axial dislocation with spontaneous bony fusion.

A case of long standing atlanto-axial subluxation following relatively minor trauma is reported. Progressive development of pain and spastic quadriparesis led to clinical and radiological investigation at Groote Schuur Hospital which revealed a spontaneous fusion of C1 and C2 with marked compromise of the spinal cord. The possibility of a pre-existing unfused odontoid process (os odontoideum) is discussed. A brief review of the literature is presented.

Atlanto-Axial Joint↗
PubMed1979

The radiographic manifestations of hypochondroplasia.

Hypochrondroplasia is an inherited skeletal dysplasia that resembles achondroplasia in mild degree. Radiographic manifestations encountered in 12 affected individuals in South Africa include slight shortening of all segments of the tubular bones, moderate caudal diminution of the lumbar interpedicular distances, increased lumbar lordosis with sacral tilt and distal prolongation of the fibula. Hypochondroplasia can be distinguished from other osteochondrodystrophies such as achondroplasia, pseudoachondroplasia and metaphyseal chondroplasia by the recognition of its clinical and radiographic manifestations.20

Adolescent↗
PubMed1979

The radiological manifestations of metaphyseal dysplasia (Pyle disease).

Pyle disease is a rare genetic skeletal disorder which is conventionally classified with craniotubular dysplasias. The radiographic manifestations in three affected adults included widening of the metaphyseal portions of the long bones which extended through a major portion of the diaphyses, with cortical thinning and mild cranial sclerosis. The femora presented the characteristic Erlenmeyer flask configuration. Pyle disease is clinically, radiographically and genetically distinct from craniometaphyseal dysplasia, a relatively common condition with which it has been confused.

Adult↗
PubMed1978

Malignant fibrous histiocytoma (malignant fibrous xanthoma: xanthosarcoma) of bone.

Seven cases of malignant fibrous histiocytoma of bone are documented. In addition to typical histologic features such as the presence of a storiform pattern, histiocytic and fibrocytic cell types and severe cellular atypism, in five cases there were areas in which osteoclast-type giant cells were prominent and the lesion resembled a giant cell tumor. Three of the seven patients developed pulmonary metastases within two years of amputation, one developed extensive local recurrence including soft tissue and vascular invasion, and the other three are without evidence of disease but have been followed for only short periods.

Adolescent↗
PubMed1978

Lethal chondrodysplasia punctata.

The radiological findings in five infants, with chondrodysplasia punctata, who died during the neonatal period are presented to illustrate the role of radiology in diagnosis and prognosis in this syndrome. Rhizomelic shortening of the limbs almost inevitably indicates an early demise. In the non-rhizomelic group, features such as excessive stippling and tracheal calcification are unreliable prognostic factors of early morbidity and mortality.

Chondrodysplasia Punctata↗
PubMed1977

Pseudoachondroplasia, a report of 13 cases.

Pseudoachondroplasia is a heterogeneous inherited skeletal dysplasia in which dwarfism is a major feature. Affected individuals have a normal craniofacial appearance and the skeletal malformations do not become apparent until early childhood. Radiographic changes observed in 13 affected individuals include shortening of tubular bones, flaring of metaphyses, variable epiphyseal maldevelopment and some degree of vertebral end-plate malformation. Diagnostic precision is essential for effective management and genetic counselling.

Achondroplasia↗
PubMed1976

Intrathoracic meningocele: a report of two cases.

Two cases of intrathoracic meningocele are reported: their association with neurofibromatosis is stressed. The likelihood of a posterior mediastinal mass occurring in a patient with neurofibromatosis being a meningocele is emphasised. A review of the literature is presented. In view of the relatively few cases of intrathoracic meningocele with neurofibromatosis documented since 1933, we feel justified in reporting these 2 cases.

Adult↗
PubMed1976

Bone infarction complicated by sarcomatous change: a case report.

A patient with a sarcoma of the tibia associated with multiple bone infarcts and a history of alcoholism, is presented. This is a rare association. The possible aetiological role of bone infarcts in relation to the development of a sarcoma is discussed.

Fibrosarcoma↗
PubMed1976

The multiple sclerotic osteogenic sarcoma of early childhood.

Two cases of sclerosing osteogenic sarcoma that occurred in early childhood are reported. They and the similar cases reviewed are unusual in their development at an unusually early age, their multicentric presentation and their densely sclerotic nature. These are uncommon manifestations of osteogenic sarcoma and are considered due to proliferative metastatic osteoid formation in areas of rapid bone growth.

Child↗