In patients with severe contusion of the brain, the concentration of ACTH in blood increases from the 2nd and to the 10th day after the trauma whereas the level of 11-OCS remains on a significantly high level during the entire period of treatment. The potential reserves of the adrenal cortex are reduced on the 5th day. The ACTH level returns to normal by the end of the 3rd week. Neurohormonal shifts play an important role in the pathogenesis of the trauma and cause the development of its clinical manifestations.

11-Hydroxycorticosteroids↗

PubMedDate not supplied

[Neuroendocrine disorders in contusion of the brain in the adrenergic-corticoid stage of stress].

The adrenergic-corticoid stage of stress in contusion of the brain is distinguished by a long duration and marked neuroendocrine changes, which must be taken into consideration in applying therapeutic measures. The duration of the neuroendocrine disorders in craniocerebral injury is determined by the severity of brain damage.

11-Hydroxycorticosteroids↗

PubMedDate not supplied

[Phasic character of neuroendocrine disorders in cerebral contusions].

A phase character of neuroendocrine disorders and their relationship with the neurological symptoms were established in patients with contusion of the brain. A long duration of the adrenergic-corticoid stage depending on the severity of the craniocerebral trauma was revealed. Regression of the neurological symptoms occurs in the stage of corticosteroid concentration reduction. Not all hormonal disorders disappear in the anabolic stage and the stage of restoration of the fat resources; this calls for pathogenetic correction with due consideration for the phase character of the course of the craniocerebral trauma.

11-Hydroxycorticosteroids↗