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Biomedical subjects

N G Starosel'tseva

Publications and source records attributed to N G Starosel'tseva.

5 recordsLinked to original sources

The polysynaptic spine-stem reflex in clinical neurology.

Data from 25 years of studies of the spinobulbospinal (SBS) reflex in normal conditions and in a variety of nervous system diseases with lesions of the afferent and efferent systems, subcortical brain formations, and musculature (contracture of the expressive muscles, myofascial pain syndrome) are presented. The instability of many characteristics of the reflex (latency, amplitude, duration of response, presence) is shown to characterize this reflex in normal conditions. These measures become more stable in central nervous system pathology, which is evidence for impairment of programs which construct and execute movements. Lesions of the peripheral neuromotor apparatus produced no significant changes in the characteristics of the SBS reflex.

Electromyography↗

[Brain somatosensory evoked potentials in myofascial pain syndromes].

Brain somatosensory evoked potentials were studied in 113 patients with chronic myofascial pains. Comparing to milder pain, pronounced pain syndrome revealed more significant functional changes (generators for pathologically enhanced excitability), on higher levels of nervous system. At the same time, in milder pain, a large quantity of low activity generators were detected that may indicate subnormal antinociceptive system activity. After treatment, the number of generators of pathologically enhanced excitation decreased significantly with migration to caudal nerve system regions. These changes may be a neurophysiological basis for myofascial pain exacerbations.

Adult↗

[Spinal-bulbo-spinal polysynaptic reflex in clinical neurology].

The data of 25-year study on "bulbar" spinal reflex (BSR) in health and different neurological diseases with afferent and efferent system damages, subcortical brain lesions and muscle lesions (mimic muscle contracture, myofascial pain syndrome are presented). The instability of the majority of the reflex characteristics (latency, amplitude, response duration, display) was shown to be its key feature in normal conditions. In a case of central nervous system pathology, stabilization of these parameters takes place that evidence for defect in the movement programming and performance. In damaging peripheral sections of neuromotor system, any substantial BSR characteristics changes were not detected.

Adolescent↗

[Fibromyalgia (generalized tendomyopathy): defect of a program of movements and their realization].

It was established that fulfillment of any motor action implies a design of the program of action in CNS and its realization by peripheral elements of locomotor system. A program includes an acceptor of the result of action and efferent synthesis on a central level (parietal-premotor area, pallidostriatal system, lymbico-reticular complex, ex cetera). A very motor act is realized by the activity of a segmental apparatus of the spinal cord and skeletal muscles. Acceptor of the result of action provides a control of the coincidence between afferent parameters of the result of an action and its real characteristics by means of the reverse feed-back (P.K. Anokhin, 1975). Incoordination of its parameters is a condition for the existence of a physiologic functional system for the construction of the necessary movement, while a coincidence of their indices resulted in the disintegration of this system. Appearance of myofascicular hypertonus in this system distorts a real parameters of the movement because of a deficit and imbalance of the proprioception in a segmental apparatus and central formations. A proprioceptive desafferentation promotes disinhibition of the neurons and formation of the generators of pathologically increased irritation with positive feed-back on rubro-segmental (A), pallido-thalamic (B), strio-piramidal (C) and parietal-premotor (D) levels of the construction of the movement according to N.A. Bernshtein (1966). Its appearance on the B and C levels prevents destruction of the physiologic system of organization after realization of its activity and promotes its reformation into the pathologic one. It manifested clinically in appearance of a pathologic dynamic stereotype. Additional integration of lymbico-reticular complex, and high centers of autonomic supplement into this system promotes a formation of the stable neurotic, depressive reactions and autonomic disorders. Such reactions are transitory and have adaptive character at normal program of construction and fulfillment of the motion, while at pathologic one they have desadaptive character. Clinically they are known as multiple psychoautonomic syndromes combined with muscular, fascial and ligamental pains of different location.

Electromyography↗