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N GOLDBLUM

Publications and source records attributed to N GOLDBLUM.

30 records · Page 2Linked to original sources
PubMed1957

Production of formalinized poliomyelitis vaccine (Salk-type) on a semi-industrial scale.

This article describes a semi-industrial method for the production of formalinized poliomyelitis vaccine developed during 1956. The general technique followed that originally devised by Salk with modifications developed locally. The vaccine was tested for safety and innocuity according to the Minimum Requirements laid down by the United States Public Health Service. Seitz filtration was found to be essential for the production of a non-infectious vaccine; filtration through glass filters proved to give inconsistent results. High initial virus titres, proper filtration methods, and the use of a sensitive tissue-culture system for safety testing were considered to be of prime importance for the production of a safe and effective vaccine. Over 60 000 infants and young children were inoculated with this vaccine in a country-wide immunization programme during the winter and spring of 1957. No untoward effects were noted; an immunological evaluation of its performance in those inoculated is in progress.

Child↗
PubMed1952

Complement-fixing antibodies to type 2 (Lansing) poliomyelitis virus in a normal population of a subtropical area.

Sera collected in 1950 from the native population in the vicinity of Cairo, Egypt, have been tested for complement-fixing antibodies to Type 2 (Lansing) poliomyelitis virus. Complement-fixing antibodies are confined to the age of 1 to 9 years if a serum dilution of 1:4 is used in the test, or to the age of 1 to 4 years with a serum dilution of 1:16. A comparison has been made of the findings obtained in this study with the results for neutralizing antibodies previously reported. Complement-fixing antibodies were found to be temporary in nature while neutralizing antibodies were maintained for long periods of time. On this basis, criteria for "recent," "old," or "no infection" in poliomyelitis have been established. Sixteen of the children were bled again in 1952, 18 months after the first bleeding and both series of sera were compared in complement fixation and neutralization tests. All children who were negative in 1950 and who developed c-f antibodies by 1952, also developed neutralizing antibodies to a titer of more than 1:250 during the same period. Some children who failed to develop c-f antibodies, did develop neutralizing antibodies although of lower titer than found in children in whom c-f antibodies made their appearance. These findings are discussed in the light of theories regarding the mode of acquisition of antibodies to poliomyelitis virus.

Antibodies↗