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Biomedical subjects

N Gabrielsson

Publications and source records attributed to N Gabrielsson.

35 records · Page 2Linked to original sources

Diminutive colonic polyps--clinical significance and management.

Of 300 diminutive polyps (up to 5 mm) found at colonoscopy, 114 were neoplastic (37 per cent) and thus possible precursors of carcinoma. This suggests that all colonic polyps, regardless of size, should if possible be extirpated or coagulated. As polyps of this small size often escape detection roentgenologically, especially by conventional technique, colonoscopy should be extended to involve the entire colon. This is because diminutive polyps, especially of neoplastic type, are common also in the proximal part of the colon.

Adult↗

Malignancy of colonic polyps. Diagnosis and management.

The risk of malignant degeneration of colonic polyps has traditionally rested on various roentgenographic criteria such as broad base, irregular surface and size larger than 1 cm. With the aim of facilitating the choice of treatment of colonic polyps, an appraisal is made of the morphology of 200 polyps removed from 154 patients. The results of barium enema and double contrast techniques are compared with those obtained at colonoscopy. Radiography is found to have considerable shortcomings in evaluation of the appearance of the polyp. As the correlation of the gross morphology of the polyp of histology is weak endoscopic polypectomy should be performed whenever possible.

Colon↗

Recurrent carcinoma of the colon in the anastomosis diagnosed by roentgen examination and colonoscopy.

After resection for cancer of the large bowel recurrence at the anastomosis occurs in about 10%. In 30 operated cases roentgenography and colonoscopy were performed. In 18 cases roentgen examination gave rise to suspicion of recurrence at the anastomosis but this was confirmed by colonoscopy and surgery only in 6 cases. In two additional cases with normal roentgenographic findings recurrence at the anastomosis and a second primary cancer were diagnosed by colonoscopy in one case each. The clinical symptoms provided no guidance in the diagnosis of recurrence. Roentgen examination is admittedly less conclusive than colonoscopy for discovery of recurrent and metachronous carcinoma. The methods are, however, complementary and both examinations should be regularly carried out in order to establish an early diagnosis.

Adenocarcinoma↗

A new technique for insertion of the colonoscope through the ileocaecal valve.

At colonoscopy it is important to examine the distal part of ileum in inflammatory diseases particularly. Different techniques for insertion of the colonoscope into the ileum have been described. In our experience these methods require considerable skill and practice. We have therefore worked out a technique for easier access to the ileum with a colonoscope. A closed biopsy forceps is used for identification of the ileocaecal valve by dislodging the upper lip. The forceps is manoeuvred through the ostium and then the colonoscope can be inserted into the ileum with the forceps as a guide.

Biopsy↗

Crohn's disease of the appendix: remission obtained by total parenteral nutrition.

A woman, aged 37 years, who had been suffering from advanced Crohn's disease for many years, was treated with long-term total parenteral nutrition (TPN), given in two 2-month periods at an interval of 6 months. Prior to the introduction of TPN there was inflammation of the appendix, the terminal ileum, and the entire colon. During the first period of TPN there was a temporary clinical and radiological improvement in the state of the intestinal tract, including the appendix. Two months after the first period of TPN abdominal pain recurred, and colonoscopy disclosed renewed severe inflammation of the mucosa from the cecum to the rectum. At operation, on day 45 of the second period of TPN, due to remaining stenosis of the terminal ileum, there was no longer any inflammation of the appendix, confirmed by histological examination.

Adult↗

Endoscopically inserted endoprosthesis in inoperable biliary obstruction.

Attempts were made to introduce an endoprosthesis into the biliary tract using endoscopic technique in 13 patients with unresectable extrahepatic biliary obstruction. In all but one papillotomy was performed. Successful insertion of the prosthesis was achieved in 11 patients, 10 of whom had effective palliation of jaundice. Mean survival was 4 1/2 months (range one week-13 months). One patient developed pancreatitis following prosthesis insertion. No further complications occurred in the series. This method is an attractive alternative to biliodigestive bypass procedures in patients with inoperable pancreaticobiliary lesions. When compared with internal and/or external drainage by the percutaneous transhepatic technique the method to place an endoprosthesis endoscopically has several advantages.

Aged↗