Biomedical subjects

N Gavrilov

Publications and source records attributed to N Gavrilov.

10 recordsLinked to original sources

PubMed1987

[Experimental studies on a decrease in hypotrophy in newborn piglets in commercial swine raising].

The birth of hypotrophic piglets with 2-3 times lower live weight than the normally born ones, which die till the 40th hour, because of the abruptly decreased vitality is described. Their percent is 7 for the reproductive bases and 10 for a commodity swine breeding complex. Studies were carried out on 402 pregnant pigs, treated with protein hydrolysate and glucose (injected) together with vitamin-mineral additions to the forage. For a control were used 395 pregnant pigs under the same conditions, but not treated with the above mentioned medicines. A two fold decrease of the birth of hypotrophic piglets was achieved. The rest of the pigs are with a higher live weight and vitality which is the reason of their suffering from coli bacteriosis and other diseases of the conditions at a considerably lower extent. It is supposed that the irreplaceable (limited) amino acids are at the base of that biological phenomena for the prophylaxis of the hypotrophy in the pathology of the hybrid industrial swine breeding. That model scheme as a method can be realized in reproductive and nuclear bases for hybrid swine breeding because of its undeniably great and economic effect.

Animal Feed↗

PubMed1987

[Multicausality in the pathology of commercial swine breeding].

Studied were more than 100,000 samples of pathologic tissue material, 1,900 whole blood and blood serum samples, 8,000 fecal samples, 2,600 washings samples, swab samples, and other sampled material via the employment of a number of bacteriologic, virologic, morphologic, hematologic, biochemical, parasitologic, and other routinely applicable laboratory methods over a period of 5 years. All materials were taken from 15 stock swine breeding complexes, 3 reproduction and 2 nucleus bases for hybrid pigs, and 3 swine breeding farms with a practice of extensive raising technology. It was demonstrated that the adaptive capacity of the animals of the Camborough hybrid sharply dropped when the pigs were kept under unconventional conditions of raising, leading to deviations in the application of industrial technology methods. This was the reason to observe the simultaneous manifestation of conditionally substantiated disease outbreaks (multiple causality), with great economic losses. Studied were the etiology and pathogenesis of coli bacteriosis, salmonellosis, gastric ulcer, hypotrophy, atrophic rhinitis, geohelminthiases, chlamydial infections, and erysipelas. Suggested is the use of programmes and methods of prophylaxis and treatment, of expedient diagnosis and control on immunity.

Animal Husbandry↗

PubMed1985

[Pathology in hybrid pig breeding due to mixed infections].

A total of 7,500 samples from 5 swine breeding complexes with 200,000 hybrid Camborough pigs were studied morphologically and bacteriologically. The raising technologies used on all complexes were of industrial type or semi-industrial and extensive. A description is given of the simultaneous participation of the following nosologic units: colibacteriosis, responsible for 13 to 14 per cent of the total mortality rate in newborn pigs; bronchopneumonia--causing 6 to 39 per cent losses in the other age groups; and dysentery with salmonellosis--inflicting 5 to 9 per cent losses. Underlined is the great advantage of the industrial technologies of animal raising as against the conventional ones in the prevention of these diseases in hybrid pig breeding. Tested were effective programmes for the prophylaxis associated with the individual nosologic units. More essential were the following: active immunoprophylaxis with live attenuated vaccines against colibacteriosis and salmonellosis; elimination of the alimentary stress factor in dysentery; disinfections of premises by gassing with a mixture of ammonium nitrate and chlorinated lime in a 1:2 ratio. However, all measures proved effective when the principle of "all in, all out' was observed which is essential part of the Camborough industrial raising technologies.

Animal Husbandry↗

PubMed1985

[Commercial method of aerogenic immunization of pigs against swine fever].

An industrial method is presented through a model with a chamber for aerogenic immunization of about 250 pigs, aged 2.5 months. The experiments were carried out with more than 1,000 pigs of the Camborough hybrid under industrial conditions of raising. The process of immunization was feasibly carried out when the pigs passed through the chamber using aerosol at mixing them upon transference from the growing section to the fattening one, according to the provisions of the raising technology. A lapinized K-vaccine against fever, obtained from rabbits or tissue cultures was used in a dispersed state. Essential proved the high titer of the vaccine. Used were the aerosol devices DAG-2 or Microjet Fogmaster mounted at 1.5 m above the chamber floor. They guarantee the production of highly dispersed aerosol of an average arithmetic size of 7-10 microns, its concentration reaching 3,000,000 particles per 1 cm3. The animals were exposed for 30 min with Fogmaster and 45 min with DAG-2. It was shown that they tolerated perfectly this group immunization. A single procedure with the vaccine conferred immunity at 2.10(5) LT50 and protected the pigs from fever over the entire fattening period. The method was evaluated as a biotechnology.

Aerosols↗

PubMed1978

[Clinical and pathomorphological studies of rabbits injected with virulent and lapinized swine plague virus].

Investigations were carried out to establish the clinical and morphological reactions in rabbits following the consecutive infection with the virulent Vratsa strain and the lapinized K strain of the swine fever virus. It was found that although the virulent strain did not cause a thermal response there were morphological lesions in the body of the rabbits, characterizing the presence of an immune response. The latter was shown to inhibit the thermal reaction in the animals after infecting with lapinized strain. It is stated that such inhibition of the thermal reaction which is typical for strain K is invariably generated if the lapinized virus is injected 120 hours after the injection of the virulent virus.

Animals↗

PubMed1978

[Control of immunity against swine plague by the viral neutralization test on rabbits].

An idea may be got on the properties of the vaccine by applying a specific gamma-globulin against swine fever in pigs, mixed in definite amounts with lapinized K-vaccine and this mixture is injected to rabbits. By studying the mixture of sera from pigs, vaccinated against swine fever prior to a fixed period of time, and the K-vaccine, applied to rabbits, an idea may be obtained on the tension of the immunity and re-vaccination requirements may be assessed.

Animals↗

PubMed1977

[Practical aerogenic immunization of swine against plague].

A total of 3,500 pigs were immunized against hog cholera (swine fever) using an aerosol lapinized vaccine strain K, immediately after weaning the animals in the fattening sectors of two cooperative swine-breeding farms. Ordinary premises for pigs were used as chambers where the vaccine was dispersed at the rate of 10 ml per cu. m with the aid of the Soviet-made apparatuses DAG-2. This type of immunization proved effective, being well tolerated, causing troubles whatever in the treated animals. The immunity produced protected them from swine fever in the course of at least ten months, which was sufficient for the pigs in the fattening sector. This positive result is obtainable at a single aerosol treatment both for pigs of sows that have not been immunized and for pigs of sows that have regularly been immunized against hog cholera.

Aerosols↗

PubMed1975

[Activity of several serum enzymes in swine with acute plague].

Nonvaccinated pigs were infected with a pathogenic virus of swine fever in order to follow up the changes with some enzymes in their blood serum. It was found that there is a dependable rise in the values of the blood serum GOT (2.6.1. 1.) - From about 38 to approximately 108 mU per cu. cm; GPT (2. 6; 1.2.;-From about 12 up to 66 mU/cu. cm; LAP (3. 4. 1. 1)-from about 13 to 27 mU/cu. cm; and ALD (4. 1; 2. 7.) - from about 6 up to 19 mU/cu. cm. These changes were noticed as early as the 48th hour of infection, prior to the manifestation of the clinical symptoms of swine fever. They remained stable up to the end of the infection process. The activity of LDH (1. 1. 2. 7.) and amylase (3. 2. 1.1 .) was said to rise (not dependable statistically), and that of cholinesterase (3. 1 1. 8) - to drop gradually with the development of the infection process. The two phosphomonoesterases (3. 1. 3. 1 and 3. 1. 3. 2.) showed no essential changes. The changes taking place in the activity of these enzymes did not depend on the extent of the hemorrhagic diathesis characteristic of swine fever. So, this test, which has been unknown so far, is referred to as a characteristic paraclinical symptom of swine fever.

Acid Phosphatase↗

PubMed1975

[Antibody formation in swine vaccinated with a lapinized K-vaccine and serum against hog cholera].

Immunized were experimentally a total of 10 pigs with 2 cu. cm lapinized K vaccine and 10 cu. cm swine fever serum each. Reimmunization was performed a month later using only vaccine. After three and a half months the experimental pigs were included into the group of pigs producing serum against swine fever that were preliminary simultaneously immunized against hog cholera by the classical method. Swine fever antibodies in the serum of the experimental pigs showed a concentration that was equal to that in the serum of the regular donors as in both cases the serum titer ranged within the limits of 0.10 to 0.12 cu. cm per kilogram body weight. It is concluded that pigs intended for serum producers can be immunized with a lapinized K vaccine and serum against swine fever on the farms supplying the animals. After building up the basic immunity, which lasts about three and a half months the pigs could be bought over and included for serum production. Thus, the pathogenic hog cholera virus of the simultaneous immunization at the Institute (producer of serum) will be eliminated, economizing forage and labor and premises for several months, which are necessary for serum producing pigs.

Animals↗

PubMed1975

[Immunological reactivity of suckling pigs born to sows immunized against the lapinized K vaccine].

The lapinized K vaccine was used to immunize 25 five-day-old pigs and 27 ten-day-old pigs. A group of 10 pigs were also included in the experiment as controls. All animals originated from eight sows treated with a lapinized K vaccine on the 70th day of pregnancy. On the 14th day following vaccination part of the pigs of the two test groups were revaccinated. Three months later half of the immunized pigs were infected with a pathogenic swine fever virus. The remaining animals were infected then in a six months time following immunization. Systematic clinical and morphological investigations were carried out. It was concluded that the 5-day-old animals possessed much lower immunologic responsiveness to the lapinized K vaccine against swine fever as against the 10-day-old ones. Revaccination with the same vaccine on the 14th day led to a weaker immune response as compared to single vaccination. The immunity of the vaccinated 10-day-old pigs, originating from sows that had been immunized with the same vaccine during pregnancy, lasted about three months.

Age Factors↗