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Biomedical subjects

N Georgiade

Publications and source records attributed to N Georgiade.

At least 19 recordsLinked to original sources
PubMed1985

Efficacy of povidone-iodine in pre-operative skin preparation.

Cultures were obtained of the microbial flora from the skin of the operation site pre-operatively and following preparation of the surgical field with povidone-iodine (PVP-I). Preliminary results indicate that PVP-I is a reasonable and effective antibacterial agent when used to prepare skin for surgical operations.

Adolescent↗
PubMed1985

A flap for moderate-sized oral defects.

The use of a cervical musculocutaneous flap is described which is easily transferable to the oral cavity to cover an osseous and soft tissue operative defect, eliminating the need for a more distant and extensive musculocutaneous flap.

Aged↗
PubMed1982

Rationale for immediate reconstruction of the breast following modified radical mastectomy.

In 62 patients in whom modified radical mastectomy was accompanied by immediate breast reconstruction, the operative and pathologic findings are compared to the clinical results. Immediate reconstruction following modified radical mastectomy appears to offer several advantages over delayed reconstruction. The data indicate that immediate reconstruction provides excellent technical results, is associated with less expense and morbidity as compared to delayed reconstruction, and does not adversely affect the natural course of the disease within the follow-up period studied. No adverse effect of adjuvant chemotherapy on the reconstructive effect was noted in this series of 62 patients when the initiation of adjuvant chemotherapy was timed so as to avoid difficulties with hemostasis. The technical aspects of the immediate reconstruction are described.

Adult↗
PubMed1982

Nipple-areola reconstruction after mastectomy.

Hypopigmentation, fibrosis, and the risk of autotransplantation of malignant cells have resulted in diminished enthusiasm for preserving the nipple-areolar complex after mastectomy. Adequate color match for areola reconstruction can be obtained with a full-thickness medial groin graft after breast mound symmetry has been achieved. Both a single-stage and a two-stage technique are described for nipple reconstruction. These techniques use existing approaches with some modification, and provide nipple-areolar complexes that are symmetrical, have satisfactory color match, and provide good nipple projection. Most important, the contralateral nipple-areolar complex is not violated. It can be dealt with as deemed best in terms of cancer prophylaxis.

Breast↗
PubMed1982

Reconstruction with vascularized composite tissue in patients with excessive injury following surgery and irradiation.

The biological effects of a single high dose of radiation are examined. Both cellular injury and repair are reviewed during early, intermediate, and late phases. Anticipated composite tissue morbidity is detailed for therapeutic radiation doses administered to the head and neck, breast and thorax, and perineum. Patients who demonstrated excessive time-dose fractionation values were irradiated with lower x-ray energies. Those in whom there was an overlap of treatment fields presented a serious challenge to the reconstructive surgeon. Judicious selection of well-vascularized composite tissue outside the portals of irradiation, preferably with a long vascular pedicle, facilitated reconstruction. When possible, both donor and recipient vasculature should be outside the irradiated area to ensure uninterrupted blood flow to the transferred or transplanted tissue.

Adult↗
PubMed1981

Immunoglobulin localization in benign and malignant lesions of the human mammary gland.

Using direct imunofluorescence, lesions from 266 human breast specimens were studied for the presence of IgA, IgM, or IgG localization. The lesions included benign elements from 66 subcutaneous mastectomy specimens in which the absence of simultaneous breast malignancy was documented, primary breast carcinomas from 153 mastectomy specimens, and 47 biopsies containing metastatic breast cancer. A statistically significant association of IgA and IgM with benign lesions was contrasted to the association of IgG with malignant lesions. In both primary and metastatic lesions, IgG localization was associated with estrogen-receptor-poor primary cancers as compared with estrogen-receptor-rich primary cancers. Among primary breast cancer patients, IgG localization in the tumor correlated with relative lymphopenia. A shorter disease-free interval was noted in association with IgG localization among the metastatic breast lesions. No statistically significant association between stage of disease and immunoglobulin presence was demonstrable. Moderate-to-severe intraductal epithelial hyperplasias were more often associated with immunoglobulin G localization that were other benign lesions.

Adult↗
PubMed1981

A silent but lethal injury associated with facial trauma.

Without a careful evaluation of all patients with major facial injuries and a thorough search for possible associated injuries, traumatic transection of the aorta may be easily missed, if the patient survives the first 24 hours after injury. Any patient subjected to sudden deceleration injury, particularly following automobile or motorcycle accidents, should be evaluated carefully for traumatic aortic rupture. Patients with associated chest trauma should have chest x-rays in the emergency room, and repeat chest films several hours later should be obtained to identify subsequent development of a widening mediastinum. Proper management of possible aortic transection should include arteriograms when appropriate and prompt surgical intervention when indicated. All patients with major injuries should be thoroughly evaluated by a trauma team so that associated injuries may be quickly recognized and treated.

Accidents, Traffic↗
PubMed1980

Use of skin staples in plastic surgery.

Skin closure with stainless steel staples can be done economically, simply, quickly, and accurately. Stapling is indicated in a wide range of surgical procedures. Scarring is minimal and patient acceptance is excellent.

Dermatologic Surgical Procedures↗
PubMed1979

Production and secretion of proteolytic enzymes by normal and neoplastic cells.

A possible mechanism for tumor cell invasion of normal tissue might be secretion of proteolytic enzymes. This study compares and contrasts production and secretion of proteinases by cell cultures of normal and chemically transformed mouse epithelial cells. Lysates of normal and neoplastic cells contain similar amounts of neutral proteinase, cathepsin D and plasminogen activator. Neither collagenase nor elastase could be identified in lysates of, or serum-free culture medium bathing, normal or neoplastic cells. Neoplastic cells secrete ten times more plasminogen activator than normal cells. Our data support the hypothesis that plasminogen activator produced by neoplastic cells could fuction to activate latent proteolytic enzymes secreted by connective tissue cells which might result in spread of neoplastic cells into normal tissue.

Animals↗
PubMed1979

Cystosarcoma phylloides. A steroid receptor and ultrastructure analysis.

Six cases of cystosarcoma phylloides were evaluated by ultrastructure and steroid receptor analysis. Electron microscopy of the lesions supported previous reports of a heterogeneous tumor consisting of pleomorphic mesenchyme and normal or proliferative epithelium. In each case estrogen and progesterone receptor analysis indicated the presence of a nonsaturable estrogen and progesterone 4S binding protein rather than a specific steroid receptor as suggested by previous studies.

Adolescent↗
PubMed1978

Histopathologic study of subcutaneous mastectomy specimens from patients with carcinoma of the contralateral breast.

Fifty subcutaneous mastectomy specimens, each of which were removed from a patient who had previously undergone radical or modified radical mastectomy of the contralateral breast for carcinoma, were age and date matched to a control group of patients with which carcinoma was not associated. The patients were evaluated with regard to specific types of epithelial proliferative lesions and other entities of fibrocystic disease without knowledge of their group membership. The results included a statistically significant dominance of certain epithelial hyperplasias in the study population and a lack of statistical significance in intergroup difference of some previously suspected lesions, such as sclerosing adenosis and gross cystic disease. It is concluded that the recognition of those forms of epitheliosis associated with carcinoma may help in the management of patients at high clinical risk for carcinoma of the breast.

Adult↗