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Biomedical subjects

N Gruden

Publications and source records attributed to N Gruden.

At least 19 recordsLinked to original sources
PubMed1987

Cadmium-manganese interaction in the rat's duodenum.

Five-week-old female albino rats were given different doses of cadmium chloride (0.002-5.0 mg) by gastric intubation daily for 3 or 7 days. Manganese-54 was used as marker to assess manganese transfer through and retention in the duodenal wall by the "everted gut sac" method. No significant differences were found in these parameters between rats receiving no cadmium and those receiving 0.002 mg cadmium daily, irrespective of the period of treatment. A daily dose of 0.02 mg cadmium decreased manganese transfer significantly but only in animals treated with cadmium for 3 days. Daily doses of 0.2 mg cadmium or higher always decreased manganese transfer and intestinal uptake significantly--an effect which was independent of whether the rats were killed on the 4th or on the 8th days of the experiment. On the whole, the effect of cadmium was much more intense in the 3-day-than in the 7-day-treated animals and it was more pronounced on manganese transfer than on its intestinal uptake.

Animals↗
PubMed1984

The effect of lactose and iron on strontium absorption.

In rats fed on a milk diet with or without the addition of lactose and/or iron the transileal strontium-85 transfer was higher by 14-38% and the intestinal strontium retention lower by 6-23% than in control rats fed on standard laboratory food.

Animals↗
PubMed1977

Influence of lead on calcium metabolism.

Five-week-old female albino rats were given 0.2 or 20.0 mg of lead acetate by gastric intubation daily for seven days. Calcium-47, applied orally or intraperitoneally, was used as marker to assess calcium retention in the body and its excretion by faeces and urine. The animals were killed three days after the last application. Calcium metabolism was unaffected by the 0.2 mg lead dose, while 20.0 mg lead per day increased its absorption from the intestinal tract.

Animals↗
PubMed1977

Suppression of transduodenal manganese transport by milk diet supplemented with iron.

The effect of iron on manganese transport through, and its retention in, the duodenal wall was studied in 5-week-old female albino rats. Animals were fed only cow's milk supplemented with different doses of ferrous sulphate (0.60-19.0 mg Fe/100 ml) for 3 days before killing. Manganese transport was studied in vitro by the method of 'everted gut sac.' In all rats fed milk supplemented with iron the manganese transport through, and its retention within, the intestinal wall was signifcantly lower than when no iron was given (0.001 greater than p less than 0.001). The suppression of both the transfer and intestinal retention of managanese suggests a saturation effect produced by iron which levels off above 5 mg Fe/100 ml milk.

Animals↗
PubMed1975

Transfer of lead through the rat's intestinal wall.

The transfer of 203Pb through the wall of the duodenum, jejunum and ileum in 6- and 26-week old female albino rats was studied by the in vitro method of "everted sacs". The lead transport through, and the lead uptake in the wall was practically the same in all intestinal segments. The influence of age on these parameters of lead metabolism was not observed by the method we used. It seems that active transport of lead in all segments of the small intestine in 6-week old rats is negligible.

Age Factors↗
PubMed1975

Lead and active calcium transfer through the intestinal wall in rats.

5-week-old female albino rats were given daily doses of lead as acetate ranging from 2 mug to 20 mg by gastric intubation for 1 week. The animals were sacrificed on the 8th day of the experiment. Calcium-45 and (in some experiments) strontium-85 were used as markers to assess their active transfer through the duodenal wall by the everted gut sac method of Wilson and Wiseman. The active transport ratios of both calcium and strontium, as well as their retention in the intestinal wall were unaffected by the lead treatment of the animals. As the total calcium transport was found earlier to be diminished by lead treatment it is concluded that lead influences the passive transport, possibly by fixation to the intestinal wall.

Animals↗