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Biomedical subjects

N H Cox

Publications and source records attributed to N H Cox.

At least 127 records · Page 7Linked to original sources
PubMed1988

The suitability of sunglasses used by patients following ingestion of psoralen.

We have investigated the types of eyewear which patients on photochemotherapy have obtained, and determined their suitability for providing adequate protection. Fifty-eight pairs of sunglasses from 53 patients were assessed. Spectral transmission was measured between 200 nm and 800 nm at 10 nm intervals. Thirty-eight pairs of glasses (66%) were found to be satisfactory. Particularly high UV transmission was recorded in 11 cases (19%), highlighting the need for increased awareness of the problem of ensuring that suitable protective eyewear is used.

Eyeglasses↗
PubMed1988

Nail dystrophy in chronic sarcoidosis.

We report details of five patients with nail dystrophy associated with sarcoidosis. All had bone cysts in the underlying terminal phalanx and had a chronic course of the disease. Radiological examination is indicated in patients with sarcoidosis and nail dystrophy as bone cysts are frequently asymptomatic.

Bone Cysts↗
PubMed1988

Effect of isotretinoin on eccrine gland function.

Sweat secretion rate, stimulated by iontophoresis of pilocarpine, was measured before and during treatment with isotretinoin in 20 patients. Sweat secretion was increased during treatment in 15 patients (75%), but the mean increase of 15% was not statistically significant (P = 0.085, paired t-test; 95% confidence limits-0.2% to +30%) and no patients had a clinically apparent alteration of sweating. We conclude that there is no important change in stimulated sweating associated with isotretinoin therapy.

Adolescent↗
PubMed1988

Thiomersal allergy and vaccination reactions.

Thiomersal is the preservative in all toxoid vaccines routinely administered to children in the UK, but exposure from other sources is uncommon. Delayed hypersensitivity to thiomersal was demonstrated in 1% of individuals attending the Contact Dermatitis Investigation Unit, and 50 of these patients with positive patch tests to thiomersal were studied. Cross-reaction with other mercurials occurred in 17 of 29 patients tested (59%). 31 of the patients replied to a questionnaire regarding vaccination reactions, and were compared with case-controls matched for age, sex, and site of dermatitis. 4 patients in each group reported reactions to vaccines which contained thiomersal, suggesting that thiomersal hypersensitivity was not associated with an increased risk of vaccination reactions. However, individual cases of severe reactions to thiomersal demonstrate a need for vaccines with an alternative preservative.

Adolescent↗
PubMed1988

Allergy to non-toxoid constituents of vaccines and implications for patch testing.

We report 3 patients with persistent symptoms at vaccination sites. All were allergic to aluminium and one to thiomersal and neomycin too. Aluminium allergy causes false positive patch test reactions and we propose methods of patch testing patients with symptoms at vaccination sites in order to avoid this problem. The practical relevance of allergy to non-toxoid constituents of vaccines is discussed.

Aluminum↗
PubMed1988

Contact allergy to clobetasol propionate.

Two cases of contact allergy to clobetasol propionate are described. Neither patient had positive epicutaneous tests to other structurally similar fluorinated steroids or to other steroids with the propionate ester, but both had multiple positive tests within the European standard battery. Comparison with previously reported cases reveals that multiple contact allergies are a frequent finding in patients with allergy to this topical steroid.

Administration, Topical↗
PubMed1987

Comparison of ketoconazole and griseofulvin in the treatment of tinea pedis.

Twenty-nine patients with mycologically proven tinea pedis were randomly allocated to oral treatment with either ketoconazole 200 mg daily or griseofulvin 1 g daily for a period of up to 8 weeks. Mycological cure rate at 4 weeks was 33% for ketoconazole and 29% for griseofulvin, and at 8 weeks was 53% and 57% respectively. The efficacy of both drugs in the treatment of interdigital tinea pedis is similar, and is considerably lower than that found with topical imidazole preparations where cure rates of over 70% are generally expected.

Double-Blind Method↗
PubMed1987

Prurigo pigmentosa.

Prurigo pigmentosa is a rare dermatosis which is most common in Japan. Although the histological features are non-specific, the clinical appearance is striking and is dominated by gross reticular pigmentation. A Chinese patient with prurigo pigmentosa is described.

Administration, Topical↗