Prophylactic Anticonvulsants for Prevention of Immediate and Early Postcraniotomy Seizures.
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Biomedical subjects
Publications and source records attributed to N H Horwitz.
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The treatment alternatives for the patient who becomes comatose following nontraumatic infarction of the cerebellum are discussed. The acute hydrocephalus produced by the swollen cerebellum is readily diagnosed by computed tomography scan and is identified as a hypodense mass without contrast medium uptake that obliterates the fourth ventricle. Two typical cases are described, one managed medically and one surgically. All available reports in the world literature of similar patients treated surgically are reviewed. Based on the outcome analysis of the foregoing, a strategy is offered for the handling of future cases.
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The authors review 531 consecutive operations for lumbar disc herniation performed on 496 patients by one neurosurgeon to determine the effect of prophylactic antibiotics upon postoperative wound infections. In this retrospective analysis 16 instances of sepsis were found, 11 considered to be major and five minor. In the 128 cases in which no antibacterial agents were given, 11 major and 1 minor infection occurred. Four minor infections developed in the 402 occasions when antibiotics were given in the perioperative period. Men had a significantly greater risk of developing infection than women. These data suggest that pre- and postoperative antibiotic therapy directed at a narrow spectrum of microorganisms reduced the incidence of significant wound infections in patients undergoing laminectomy for lumbar disc herniation.
A device that permits accurate dispensing of individual doses of 133Xe from multicurie ampuls is described. The advantages include economy, flexibility in dose selection, and radiologic safety.
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