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Biomedical subjects

N H Sternby

Publications and source records attributed to N H Sternby.

At least 55 records · Page 3Linked to original sources
PubMed1978

Pathology of centenarians. II. Urogenital and digestive systems.

The urogenital and digestive systems in 23 centenarians (7 males and 16 females) were examined pathologically. In the urogenital system, macroscopic scar formation, chronic pyelonephritis and arterio- and arteriolosclerosis of the kidney usually were pronounced. Six instances of prostatic glandular hyperplasia were demonstrated, and three of these were associated with well-differentiated adenocarcinoma. The testis, ovary and uterus usually showed a strong tendency toward atrophic changes. In the digestive system, senile atrophy of the liver and formation of colonic diverticula were noted. In this series of aged subjects, malignant lesions of the gastrointestinal tract were rare. It is also noteworthy that the unsuspected lesion of massive gastrointestinal hemorrhage associated with the various observed disorders might have been the cause of death in some of these centenarians.

Aged↗
PubMed1977

Latent carcinoma of prostate at autopsy in seven areas. The International Agency for Research on Cancer, Lyons, France.

A world-wide comparative study of the frequency and characteristics of latent carcinoma of the prostate was undertaken in seven areas, using standardized methods and "blind" microscopic evaluation in order to reduce selection and observer bias. The morphological features of 350 latent carcinomas found in 1,327 prostates were examined. Two Chinese populations, from Hong Kong and Singapore, showed a low frequency of latent carcinoma in comparison with western Europeans in Sweden and the Federal Republic of Germany and negroes from Jamaica; an intermediate position was found for Israelis and black Ugandans. The frequency of small latent carcinomas was about 12% in all the areas investigated and did not vary with age. Rates for larger latent carcinomas increased sharply with age ans showed an area-to-area variation resembling that of clinical carcinoma of prostate. The small carcinomas were almost exclusively situated in the outer half of the prostate and latent carcinomas of all sizes were evenly distributed between the anterior and posterior halves of the prostate and the right and left sides of the outer prostatic shell. Certain disagreements in diagnosis were noted when the sections from each area were evaluated independently by a different pathologist. Most of these disagreements were resolved by re-reading the sections; their occurrence had no significant effect on the geographical comparisons.

Age Factors↗
PubMed1977

Effects of a health screening on mortality and causes of death in middle-aged men. A prospective study from 1970 to 1974 of mean in Malmö, born 1914.

All men born in even-numbered months in 1914 and domiciled in Malmö were invited in 1969 to participate in an investigation regarding risk factors for cardiovascular disease. Individuals with a blood pressure of 165/110 and over were treated and a sub-sample of heavy smokers were later invited to take part in a quit-smoking project. During the following five year period total and cause-specific mortality in the examined group was compared with corresponding data for men born in uneven months in 1914. Mortality in the examined cohort was lower than among controls and differed significantly from that in the control group with regard to cardiovascular mortality.

Cardiovascular Diseases↗
PubMed1976

Atherosclerosis and malignant tumours.

Aortic and coronary atherosclerosis were studied in subjects with a malignant disease and compared with those in the three atherosclerosis reference groups. In general, subjects with a malignant disease had little atherosclerosis, except for men with lung or prostatic cancer; in particular, men with lung cancer tended to have more extensive aortic atherosclerosis. Atherosclerosis was less extensive in subjects with tumours specific to females. The ratios between the different types of lesions was preserved and the change was therefore quantitative rather than qualitative. No proof of a real negative influence on atherosclerosis by malignant diseases was found but wasting could be one factor influencing the development of atherosclerosis in tumour subjects. Such subjects, except those with lung and prostatic cancer, could have been included in the low atherosclerosis group which was an index of the mean basic level of atherosclerosis in the populations studied.

Adult↗
PubMed1976

Atherosclerosis and peptic ulcer.

Aortic and coronary atherosclerosis and the frequency of coronary stenosis and myocardial lesions were studied in subjects with peptic ulcer, in two subgroups with acute and chronic peptic ulcer, and in subjects who had undergone a stomach operation. In all these respects the groups were similar to each other. Men with peptic ulcer had the same amount of aortic atherosclerosis as the standardized average coronary atherosclerosis group but less coronary atherosclerosis, while women with peptic ulcer had less aortic and much less coronary atherosclerosis. The prevalence of coronary stenosis, fresh myocardial infarction, and myocardial scar was very low in those with peptic ulcer, especially in women.

Adult↗
PubMed1976

Atherosclerosis in relation to tuberculosis and chronic lung disease.

The relation between atherosclerosis and tuberculosis and other chronic lung diseases was studied in extensive autopsy material. Aortic atherosclerosis in subjects with such conditions was generally similar in extent to that in the standardized atherosclerosis group and more extensive than that in the low atherosclerosis group, while coronary atherosclerosis was less extensive than in the standardized average group and, especially in women, approximated to that in the low atherosclerosis group. The prevalence of coronary stenosis and myocardial lesions was very low in subjects with tuberculosis and other chronic lung diseases. The presence of such diseases seemed to increase the development of atherosclerosis in the thoracic part of the aorta in relation to the abdominal part.

Adult↗
PubMed1976

Atherosclerosis and body build.

In a large autopsy series the relation between various measures of body build and aortic and coronary atherosclerosis, coronary stenosis, and myocardial lesions was studied. Stature was not associated with any of these variables. Various measures of obesity all showed an association between obesity and the above-mentioned variables. Obese people were found to have more coronary atherosclerosis, coronary stenosis, and myocardial lesions than thin people, a difference that persisted, in a reduced form, when hypertensives and diabetics were excluded. When compared with the standardized average atherosclerosis group to exclude the effect of "wasting diseases", and when hypertensives and diabetics were excluded, neither the extent of atherosclerotic lesions nor the prevalence of coronary stenosis were increased in obese subjects. Obese men but not obese women, however, had more myocardial lesions, especially fresh myocardial infarction.

Adult↗
PubMed1967

Comparative studies of atherosclerosis in swine.

A survey of spontaneously occurring fatty streaks and fibrous plaques, considered as atherosclerosis, in 1637 swine in different European countries and the USA, using a standardized procedure, was undertaken to determine whether significant differences exist in the occurrence and extent of the disease in various groups of animals. At the same time a preliminary study on the possible relation of any differences observed in atherosclerosis to certain environmental and constitutional factors was carried out with the ultimate goal of contributing to the understanding of analogous problems in man.STATISTICALLY SIGNIFICANT INCREASES OF FATTY STREAKS AND FIBROUS PLAQUES WERE NOTED IN RELATION TO: (a) increasing age, starting at 6 to 7 months, the earliest age period studied; (b) geographical locality; and (c) considerable as compared with moderate or slight physical activity at 1 year of age. Although not statistically significant, there was also a suggestive trend towards more atherosclerosis in pigs consuming soft water as compared with those consuming hard water.While these correlations may represent contributory factors to the increases of the changes noted in the abdominal aortas, it is not possible to pinpoint the importance of individual components because of the limited data and the large number of variables involved in this preliminary study. Studies in swine and other animals are being encouraged in which all variables but one are being kept constant to determine their possible role in the development of atherosclerotic lesions.

Age Factors↗