Biomedical subjects

N Hazemoto

Publications and source records attributed to N Hazemoto.

3 recordsLinked to original sources

PubMed1992

Enantiomeric difference in percutaneous penetration of propranolol through rat excised skin.

The percutaneous penetration of R-(+)- and S-(-)-propranolol (PL) through rat excised skin was investigated in vitro. The flux of S-(-)-PL after application to normal skin was high compared with that of R-(+)-PL. On the other hand, in damaged rat skin, the flux of R-(+)-PL was almost equivalent to that of S-(-)-PL. It is suggested that there is an enantiomeric difference between S-(-)- and R-(+)-PL in terms of penetration through rat stratum corneum.

Animals↗

PubMed1976

Electrode sensitive to sulfa drugs.

An electrode sensitive to sulfa drugs was constructed by using the iron(II)-bathophenanthroline chelate embedded in a liquid membrane. Rapid and Nernstian responses were exhibited against solutions of sulfamerazine and sulfisomidine ranging between 10(-3) and 10(-1) M in concentration. High selectivity was observed in the presence of urea, glycine, aminopyrine, or p-amino-benzoic acid. These chemicals are known to interfere in the usual colorimetric analysis of sulfa drugs.

Chemical Phenomena↗

PubMed1976

Ion selective electrode for 2,4-dichlorophenoxyacetic acid.

An electrode responsive to 2,4-D (2,4-dichlorophenoxyacetic acid) was constructed by dissolving tetrazolium derivatives as an ion exchanger in a liquid membrane. The electrode exhibited rapid and Nernstian response to solutions of 2,4-D over the concentration range 10(-1) to 10(-4)M. The presence of diverse substances such as acetate, benzoate, and 3-indoleacetate showed no appreciable effect on the electromotive force of the electrode.

2,4-Dichlorophenoxyacetic Acid↗