Biomedical subjects

N Heisig

Publications and source records attributed to N Heisig.

3 recordsLinked to original sources

PubMed1978

[Endoscopic findings in Whipple's disease (author's transl)].

In a patient with massive ascites, bouts of fever of unknown aetiology and cachexia, duodenoscopy and laparoscopy revealed white-yellow, partly confluent, nodules and plaques on the duodenal mucosa, and the surface of the liver and the peritoneum of the upper right abdominal quadrant, leading to the diagnosis of Whipple's disease. Histological examinations of these deposits revealed an accumulation of PAS-positive macrophages (SPC cells = sickle-form particle containing cells) and lysosomal bacterial inclusions under the electron-microscope. This raises the possibility of a simple endoscopic method for diagnosing Whipple's disease.

Biopsy↗

PubMed1977

[Effects of a coffee-antacid-mixture and a commercial coffee with regard to gastrin, pH and gastric secretion (author's transl)].

The influence of a coffee-antazid-mixture was investigated at 30 patients with diseases of the stomach (17 with duodenal ulcer, 6 with gastric ulcer and 7 with chronic gastritis) in comparison to a commercial coffee. The parameters measured were the gastric basal acid output, the continuous registration of the pH by an intragastric electrode and the serum gastrin concentration before and after the application of the tests substances. 75% of the patients with duodenal ulcer showed a positive effect by means of a greater elevation of the intragastric pH after application of the mixture in comparison to coffee. The effect was strongly correlated to the basal acid ouptput. In the group with gastric ulcer and that with duodenal ulcer under the influence of the mixture the pH after the initial rise decreased to less deeper values. There was a close relationship to the patterns of gastric ulcer as well with chronic gastritis there was an additional facourable effect on the symptoms of abdominal pain which occured after coffee and not after the mixture. The group with chronic gastritis showed no difference between the pure coffee and the coffee-antacid-mixture. A possible relationship of the products of coffee roasting and the adsorptive properties of the antacid is discussed.

Adult↗

PubMed1976

[On the alpha-fetoprotein in the diagnosis of primary liver carcinoma (author's transl)].

The existence of Alpha-Fetoprotein was investigated in sera of 544 patients with laparoscopically and/or histologically proved chronic liver diseases and cancer of the liver. The applied methods were the double-diffusion technique (micro-Ouchterlony), the counter immunelectrophoresis and the latex agglutination test. In 15 patients with primary cancer of the liver there was a positive result for Alpha-Fetoprotein with the first two methods, 73,3 and 80,67%, respectively. In other liver diseases (liver cirrhosis, chronic hepatitis, malignant tumors with liver metastases) there were only a few positive results (4,17% in patients with liver metastases of unknown origin and less than 1% for the other disease groups). In this group the latex test showed a higher frequency of positive tests for Alpha-Fetoprotein, however with a concomitant rise of positive Waaler-Rose test in 80-93%. In the case of a positive rheumatic factor the latex test will therefore demand a cautious judgement because the latex particle coated with rabbit-anti-Alpha-Fetoprotein-globulin could be agglutinated by anti-rabbit-globulin existing in human serum. A correlation between the existence of Alpha-Fetoprotein and clinical parameters or laboratory datas does not exist. Increases of Alpha-Fetoprotein shown by counter immunelectrophoresis exist in primary cancers of the liver and embryonic tumors, sometimes and only temporarely in acute viral hepatitis, in some sorts of liver cirrhosis of indian children and in the case of pathologic gestation. If these last-named diseases are excluded a positive test for Alpha-Fetoprotein by precipitation methods is highly suggestive for primary cancer of the liver. Finally, the determination of this substance has a certain value for the therapeutic control of Alpha-Fetoprotein positive malignant tumors.

Adolescent↗