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Biomedical subjects

N Hibi

Publications and source records attributed to N Hibi.

At least 91 records · Page 5Linked to original sources
PubMed1979

Real time observation of left atrial myxoma with high speed B mode echocardiography.

Four patients with left atrial myxoma were studied using high speed B mode echocardiography with a mechanical sector scanning system. In all four patients, a mass of echoes was recognized in the left atrial chamber during systole. Its lower portion protruded into the left ventricle through the mitral orifice in diastole. The degree of protrusion of the tumor echo varied. An analysis of three cross sections, long axis of left ventricle, sagittal and horizontal axes, showed that the tumor moved anterosuperiorly to posteroinferiorly in the left-sided heart chambers. Its movement was clearly observed in real time. The echo pattern from the tumor had an appearance of mottling, not layering. The myxomas were successfully removed from the left atrial chambers by surgical intervention in all cases.

Adolescent↗
PubMed1979

Clinical study on the right-sided Austin Flint murmur using intracardiac phonocardiography.

Right heart catheterization was carried out on 14 patients with pulmonic regurgitation using intracardiac phonocardiography. All the patients showed pulmonic regurgitant murmur in the right ventricular outflow tract. In addition, seven out of the 14 patients showed mid-diastolic and presystolic murmurs maximally in the outflow tract of the right ventricle. Furthermore, inspiration increased the loudness of these diastolic murmurs in four patients. These findings were compatible with those of right-sided Austin Flint murmur due to functional tricuspid stenosis in pulmonic incompetence. Ten out of the 14 patients had pulmonary hypertension and all the subjects with a rightsided Austin Flint murmur showed elevated pulmonary arterial pressure. Thus, pulmonic regurgitation with pulmonary hypertension is thought to be closely related to the right-sided Austin Flint murmur and the turbulence resulting from antegrade flow across a closing tricuspid valve may be responsible for the genesis of the murmur.

Adolescent↗
PubMed1979

Cross-sectional and M-mode echocardiographic study on ventricular septal defect.

One hundred and eight patients with ventricular septal defect (VSD) including 20 operated patients were studied with real time cross-sectional echocardiography combined with M-mode echocardiography. The subjects were divided into 3 groups according to the cross-sectional echocardiographic findings. Group 1 included 34 patients in whom the defect area of interventricular septum (IVS) was demonstrated and they were diagnosed as VSD solely with this method. The majority of the patients in this group showed marked pulmonary hypertension and severe cardiac symptoms. Group 2 consisted of 13 patients who showed abruptly posterior movement of IVS toward the left ventricular cavity at early diastole and were suspected of VSD. Group 3 consisted of 41 patients with VSD showing normal cross-sectional echocardiograms without echo discontinuity of IVS. This group had a small defect of IVS with near normal pulmonary artery pressure. The analysis of cross-sectional echocardiogram combined with M-mode echocardiogram and the data of other cardiac examinations revealed that group 1 showed a larger left-to-right shunt at the ventricular level, severer pulmonary hypertension and more marked heart enlargement than groups 2 and 3. The patients with visualized defect of IVS had severe cardiac signs and symptoms and were indicated for the cardiac surgery. In the postoperative patients, the patch echo was clearly recognized as a linear strong echo. Real time cross-sectional echocardiography is available to visualize directly the defect of IVS in the majority of the patients with VSD and to estimate the condition of patients with this lesion.

Adolescent↗
PubMed1978

Studies on Epstein-Barr virus-related antigens. III. Purification of the virus-determined nuclear antigen (EBNA) from non-producer Raji cells.

The purification of Epstein-Barr virus-determined nuclear antigen (EBNA) was attempted on the basis of its biochemical and physicochemical properties and its immunological specificity, assayed by the indirect single radial immunodiffusion test and anti-complement immunofluorescence absorption test. When non-producer Raji cell extract was subjected to 20--60% saturated ammonium sulfate fractionation, followed by DNA-cellulose chromatography and immunoadsorbent chromatography, EBNA was purified more than 3,000 times with a 8% yield. Such purified protein was composed of three polypeptides with molecular weights of 100,000 +/- 5,000, 70,000 +/- 5,000 and 50,000 daltons, respectively, on SDS-polyacrylamide gel electrophoresis. Similar purification was achieved by heating the extract at 70 degrees C for 10 min, instead of ammonium sulfate fractionation, followed by DNA-cellulose chromatography and immunoadsorbent chromatography. This final preparation consisted almost exclusively of 100,000 +/- 5,000 daltons polypeptide, 50,000 polypeptide, and the 70,000 +/- 5,000 polypeptide passing through the adsorbent column. These findings suggest that EBNA is probably a molecular complex of three smaller subunits of heat-stable 100,000 +/- 5,000 and 50,000 daltons and heat-labile 70,000 +/- 5,000 daltons polypeptides, respectively.

Ammonium Sulfate↗
PubMed1978

Real time observation of left ventricular aneurysm by B mode echocardiography.

This paper describes two cases of left ventricular aneurysm following myocardial infarction by real time B mode echocardiography with a mechanical sector scan. The most distinctive feature was the paradoxical movement of the aneurysmal wall; in systole, it moved posteriorly to form a bulge, whereas the remaining noinfarcted area was oriented toward the left ventricular cavity in contraction. The final diagnosis was verified by aneurysmectomy.

Adult↗
PubMed1978

Origin of the basal systolic murmurs in mitral stenosis. A study with intracardiac phonocardiography.

In order to study the origin of the basal systolic murmurs in mitral stenosis, left and right heart catheterization was performed in 18 patients with mitral stenosis using intracardiac phonocardiography. Our data revealed that the basal systolic murmurs originated in the aorta, the pulmonary artery, and the outflow tract of the right ventricle. In 14 cases, we noted the maximal ejection systolic murmur in the aorta near the aortic valve. However, in two cases, there was a loud systolic murmur in the pulmonary artery. These murmurs occurred in early to mild-systole and were crescendo-decrescendo in configuration. The pitch of the murmur ranged from low to medium frequency in the majority of cases. They are produced by the turbulence of blood flow in the aorta and the pulmonary artery. A late systolic murmur was also recorded in the outflow tract of the right ventricle in two patients. This is thought to occur due to functional or relative infundibular stenosis of the right ventricle. It differs in location and timing from those in the aorta and the pulmonary artery. The outflow tract of the right ventricle is regarded as the third origin of the basal systolic murmur in mitral stenosis.

Adult↗
PubMed1978

Enzyme-immunoassay of human alpha-fetoprotein.

An enzyme-immunoassay for the quantitation of human alpha-fetoprotein was developed employing the so-called sandwich method using filter paper discs as a solid-phase. Filter paper discs were activated with cyanogen bromide and the specific antibody to alpha-fetoprotein was covalently bound to the discs. The enzyme-labeled antibody was prepared by coupling the antibody to alkaline phosphatase with the aid of glutaraldehyde. The antibody-coated filter paper discs were incubated with the samples containing alpha-fetoprotein, which was bound to the discs, then the discs were incubated with the enzyme-labeled antibody solution. The enzyme activity bound on the discs was then measured, and was found to be proportional to the amount of alpha-fetoprotein in the sample. The present method provided an accurate measurement for human alpha-fetoprotein in test serum in a range of 40 approximately 1,000 ng/ml. The sensitivity was almost comparable to that of radioimmunoassay. alpha-Fetoprotein levels in the normal and patient sera tested with this method were in good agreement with the values obtained by the radioimmunoassay technique.

Alkaline Phosphatase↗
PubMed1977

Clinical application of high speed B mode echocardiography.

This study discusses the clinical application of high speed B mode echocardiography to a wide variety of heart diseases. We used a rapid mechanical sector scan at 30 frames per second and 120 scanning lines per frame, resulting in real time observation of cardiac structures. The sector angle was relatively wide (maximum 90 degrees). The tomograms were synchronized with the electrocardiogram and recorded on ordinary 35 mm or Polaroid film in conjunction with 8 mm cinematography. Heart cross sections could be recorded even in the presence of arrhythmia. We used a flat or focused, 10 mm diameter transducer made of lead zirconate-titanate with a resonant frequency of 2 or 3 MHz at a repetition rate of 3.6 kHz. High speed B mode echocardiography is a means of observing cross sections of the heart that can contribute to the improvement of accuracy in cardiac diagnosis.

Echocardiography↗
PubMed1977

Real time observation of the echo source of systolic hump in hypertrophic obstructive cardiomyopathy with high speed ultrasono-cardiotomography.

The present study was undertaken to discuss the echo source of systolic hump in hypertrophic obstructive cardiomyopathy (HOCM) from a viewpoint of B-mode echocardiography. Cross-sectional images were obtained from 4 patients with HOCM using a Sonolayergraph of Toshiba, SSL-51H. This equipment is characterized by its high speed mechanical sector scanning and wider angle. Recordings were made with ordinary 35 mm camera or Polaroid in conjunction with 8 mm cinecamera. Our data showed that systolic hump in this lesion was not caused by anterior systolic movement of anterior mitral leaflet, but was emanated from the chordae tendineae attached to the anterior or posterior mitral leaflet. In systole, the anterior mitral leaflet moved backward for closure, while the chordae tendineae approached the bulged interventricular septum resulting in the formation of systolic hump.

Adolescent↗
PubMed1977

Clinical study on the acoustic phenomena in coronary venous system with intracardiac phonocardiography.

In order to study the intracardiac murmurs in coronary venous system, right heart catheterization was carried out on 35 patients with or without mitral regurgitation. The double-lumen phonocatheter of A. E. L. was used for 33 cases but for 2 the microtip phonocatheter of Millar was employed. As a rule, simultaneous recording of intracardiac and external phonocardiograms was made with the pressure tracing in the majority of cases. The examined subjects were divided into 3 groups; 9 cases with mitral regurgitation confirmed by left ventriculography (Group I), 20 without mitral regurgitation (Group II), and 6 with functional systolic murmur (Group III). In Group I, a loud systolic murmur was recorded in 7 cases (MR 5, MR + AR 1, ECD 1), but in none of IHSS in the coronary sinus or great coronary vein. In Group II, no systolic bruit was noted in VSD and other lesions except ASR in the coronary venous system. The same was true in patients with functional systolic murmur (Group III). Intracardiac phonocardiography is thought to be useful to record mitral regurgitant murmurs in the coronary venous system, since the latter is in the close proximity to the mitral posterior commissure or mitral annulus.

Adult↗
PubMed1976

Real-time observation of cardiac movement and structures in congenital and acquired heart diseases employing high-speed ultrasonocardiotomography.

Echocardiography has proved useful for cardiac diagnosis during the past several years; however, the conventional one-dimensional ultrasound pulse echo method cannot easily visualize the anatomical relationships of the various cardiac structures. To overcome the limitation, the authors attempted a real-time observation of cardiac structures and introduced high-speed ultrasonocardiotomography with a Sonolayergraph Model SSL-51H (Toshiba) having a logarithmic amplifier. Thirty sector images are produced per second by a mechanically operated, single flat or 75 mm. focus transducer measuring 10 mm. in diameter. The angle of a sector image composed of about 120 scanning lines is arbitrarily changeable from null to 65 degrees. The fast succession of images produced enables clear observation of the movement of cardiac structures in real time. Study of 230 patients by means of the proposed system suggests that it is advantageous as a quick method to provide two-dimensional echocardiograms for cardiac diagnosis and assessment, especially in noninvasive diagnosis.

Adult↗
PubMed1976

Clinical study on the flow murmurs at the defect area of atrial septal defect by means of intracardiac phonocardiography.

In order to study flow murmurs through atrial septal defects, right heart catheterization was performed on 48 patients of secundum type, four of primum type, and five of probe-patent foramen ovale, with the double-lumen phonocatheter of Lewis, at the tip of which barium titanate was mounted. The flow murmurs at the defect area were classified into three patterns: v murmur, atriosystolic murmur, and mid-diastolic murmur. V murmur was continuous, extending from late systole to diastole, of low to medium pitch, closely related to atrial v wave and augmenting with expiration. It had no significant correlation to the ratio of left-to-right shunt. It was recorded in 32 out of 48 cases of secundum type and one of primum type, but not observed in probe-patent foramen ovale. Atriosystolic murmur was noted in 17 of 48 cases of secundum type and one of primum type. It was connected with atrial a wave. Mid-diastolic murmur was found at the defect area in four subjects of secundum type. It was thought to be an independent entity from v murmur and to be another one due to shunt flow through the septal defect, since it had no relation to v wave but it was localized between v and a waves in the pressure curve of the right atrium. It is different in localization from mid-diastolic murmur due to relative tricuspid stenosis at the inflow tract of right ventricle.

Adult↗
PubMed1976

Real-time observation of ruptured right sinus of Valsalva aneurysm by high speed ultrasono-cardiotomography. Report of a case.

A two-dimensional echocardiographic manifestation of a ruptured right sinus of Valsalva aneurysm is described in this case report. The ultrasono-cardiotomograms demonstrated the aneurysm cut longitudinally and protruding into the outflow tract of the right ventricle. The configuration of the aneurysm was consistent with the contrast medium-filled sinus demonstrated by angiocardiography. In systole, the aneurysmal sinus moved anteroinferiorly together with the aortic wall. The echocardiogram revealed an abnormal two-layered horizontal echo in the right ventricle which showed the aneurysm when the ultrasonic beam passed through the interventricular septum near the aortic root and mitral leaflets. During the operation, the protruding sinus and a small interventricular septal defect in the membranous septum under it were observed through the opened right ventricle. After the closure of the aneurysm, the two-dimensional echocardiogram no longer showed an abnormal configuration.

Adult↗
PubMed1976

Differential diagnosis of pulmonic stenosis by means of intracardiac phonocardiography.

The purpose of the present paper is to describe the origin of the systolic murmur in pulmonic stenosis and to discuss the diagnostic possibilities of intracardiac phonocardiography. Right heart catheterization was carried out with the aid of a double-lumen A.E.L. phonocatheter on 48 pulmonic stenosis patients with or without associated heart lesions. The diagnosis was confirmed by heart catheterization and angiocardiography in all cases and in 38 of them, by surgical intervention. Simultaneous phonocardiograms were recorded with intracardiac pressure tracings. In valvular pulmonic stenosis, the maximum ejection systolic murmur was localized in the pulmonary artery above the pulmonic valve and well transmitted to both right and left pulmonary arteries, the superior vena cava, and right and left atria. The maximal intensity of the ejection systolic murmur in infundibular stenosis was found in the outflow tract of right ventricle. The contractility of the infundibulum greatly contributes to the formation of the ejection systolic murmur in the outflow tract of right ventricle. In tetralogy of Fallot, the major systolic murmur is caused by the pulmonic stenosis, whereas the high ventricular septal defect is not responsible for it. In pulmonary branch stenosis, the systolic murmur was recorded distally to the site of stenosis. Intracardiac phonocardiography has proved useful for the differential diagnosis of various types of pulmonic stenosis.

Adolescent↗