Privacy and publication.
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Biomedical subjects
N Hoeldtke
Publications and source records attributed to N Hoeldtke.
Little knowledge and limited practice: emergency contraceptive pills, the public, and the obstetrician-gynecologist.
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Contraceptives, Oral↗
Metabolic parameters that predict response to clomiphene citrate in obese oligo-ovulatory women.
OBJECTIVE: To determine whether the presence of insulin resistance in obese subjects would adversely affect the rate of ovulation induction by clomiphene citrate. RESULTS: Fasting hyperinsulinemia was associated with the failure to ovulate in response to clomiphene. In addition, other parameters found to correlate with insulin resistance and clomiphene citrate non-response were elevations of total and free testosterone and lower serum sex hormone-binding globulin. CONCLUSIONS: The existence of the presence of endocrine abnormalities associated with hyperinsulinemia and insulin resistance may serve as clinical indicators to help predict which obese patients are likely to respond to clomiphene citrate therapy.
Adult↗
Effects of lipopolysaccharide on interleukin-6 production in perfused human placental cotyledons.
OBJECTIVE: To determine if lipopolysaccharide (LPS) alters production of interleukin-6 (IL-6) or vascular tone in perfused placental cotyledons. METHODS: Control and study cotyledons from nine placentas were perfused for 3 h. Study cotyledons received LPS in concentrations of 0.01 mcg/ml (n = 3), 0.1 mcg/ml (n = 3), or 1.0 mcg/ml (n = 3). Effluents were collected at 30, 60, 120, and 180 min following infusion with LPS. IL-6 concentrations were measured by enzyme-linked immunosorbant assay. Perfusion pressures were recorded at 10-min intervals. Data were analyzed using ANOVA for repeated measures. RESULTS: IL-6 production significantly increased over time in both the study and control cotyledons (P = 0.002). LPS treatment did not affect IL-6 production (P = 0.85) and there were no observable dose effects (P = 0.13). Perfusion pressures did not differ (P = 0.16). CONCLUSIONS: The isolated perfused placental cotyledon produces IL-6 and concentrations increase over time. LPS does not alter production of IL-6 or fetoplacental vascular tone.
Dose-Response Relationship, Drug↗