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N I Blinova

Publications and source records attributed to N I Blinova.

12 recordsLinked to original sources
PubMed1978

[Role of normal microflora in the treatment of vibrio carrier state in rat gnotobionts].

Materials on the study of interactions between Vibrio cholera El Tor and some indigenous bacteria of human intestinal tract, which proved to be active antagonists in vitro, are presented in this work. Experiments were conducted on gnotobiotic rats (Fisher), using various combinations and variants of the order of the microorganism administration; there were revealed no antagonistic relations between Virbrio cholerae El Tor and Escherichia coli M-17, Lactobacillus fermenti, Lactobacillus plantarum. Vibrio cholera El Tor disappeared completely from the intestinal tract of the rats after its contact with the fecal microflora of healthy rats.

Animals↗
PubMed1977

[Change in the normal microflora of the intestinal tract of rats in the process of their decontamination].

The authors studied a possibility of decontamination of animals by using antibiotics and a sterile diet, and also a combination of both methods. A reduction of the species composition of the intestinal microbial flora was noted in rats on sterile diet kept under conditions limiting the penetration of microbes into the organism from the external environment. Its greatest rarefaction -- practically to individual species -- was observed when the antibiotics were used in combination with a partial gnotobiotic isolation. In studying the action of antibiotics on the bacterial flora it is recommended to use the gnotobiotic isolation chamber to prevent the entrance of vulgar microbial flora from the surrounding environment.

Animal Feed↗
PubMed1976

[Model of a chronic Vibrio cholerae carrier based on gnotobiotic rats].

Germ-free monoflora (contaminated with nonpathogenic spore-bearing bacillus) and common albino rats (OFA) were infected with V. cholera El Tor, of Ogava and Inaba serological types (6 milliard microbial cells per 1.5 ml of physiological solution per rat). Approximately one week after the infection the number of vibrios reached hundreds of millions per 1 g of feces and persisted at this level for over 100 days (observation period). Newborn rats were infected by natural way from adult vibrio carriers and also became vibrio-carriers. The number of vibrios excretedby the animals which were germ-free and monoflora before the infection was approximately the same. Cholera vibrios perished completely in the enteric tract and were never revealed in the feces of common (control) rats.

Animals↗