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Biomedical subjects

N I Gerasimenko

Publications and source records attributed to N I Gerasimenko.

At least 19 recordsLinked to original sources
PubMed1985

[Isolation of diphosphatidylglycerol, phosphatidylethanolamine and phosphatidylcholine from the bull heart].

A novel efficient procedure based on silica gel column chromatography has been developed for isolating chromatographically pure diphosphatidylglycerol, phosphatidylethanolamine and phosphatidylcholine. For this purpose the lipid extract is treated with aqueous MgCl2, whereas aqueous ammonia is added to the eluent systems. To raise the yield of lipids, a fractional loading of columns with portions of lipid extracts is employed, each loading being followed by partial elution of neutral lipids with chloroform. Optimal phospholipid--silica gel ratio is 1:20 for such a procedure. The presence of cation exchange between the lipid extract and silica gel is confirmed and its influence on the efficacy of phospholipid separation is discussed.

Animals↗
PubMed1983

[Hemodynamic indicators, phase structure of the systole of the left and right heart ventricles and the state of pulmonary circulation and microcirculation in patients with hypertension treated with adelphane-esindex].

A total of 58 patients were treated with adelphane-esidrex for hypertension, Stage II. Their general condition improved considerably and arterial blood pressure obviously decreased. The hypotensive effect of the treatment was associated with a considerable fall of high systemic peripheral resistance in most patients, and with reduced systolic and minute blood volume in others. An improvement was noted in the phasic pattern of left and right ventricular systole, pulmonary circulation, external respiratory function and also microcirculation.

Adult↗
PubMed1977

[The phospholipid composition of organs and tissues of rabbit].

The phospholipid compositions of 11 organs and tissues of rabbit (brain, heart, lung, liver, muscles, kidney, spleen, bone marrow, pancreas, adrenula, and blood plasma) were comparatively studied by micro-thin-layer chromatography. Total lipid extracts of liver and brain are the most abundant in phospholipid (61,8% and 56,3%, respectively) and that of bone marrow and spleen are the poorest (1,6% and 7,1%, respectively). All the organs and tissues, except blood plasma, contain phosphatidyl choline, phosphatidyl ethanolamine, phosphatidyl serine, phosphatidylinositol, sphingomyelin and diphosphatidylglicerol; the majority of organs contain phosphatidic acid. Lyso-phosphatidyl-choline was detected in blood plasma, bone marrow, adrenula and liver. Phosphatidylglicerol was found only in the lungs. Brain has the lowest content of phosphatidyl choline (34,3%) and the highest contents of phosphatidyl ethanolamine (36,2%) and phosphatidyl serine (12,6%), whereas the heart is the richest in DPG (about 11%). Diphosphatidyl glycerol is the most abundant in the heart (approximately 11%) and phosphatidyl inositol-- in the adrenula (8,1%). Plasma is found to have a high content of choline-containing lipids; however, phosphatidyl serine and phosphatidic acid are absent altogether. Some of the organs and tissues have a similar phospholipid composition; namely brain and kidney, spleen and bone marrow, adrenula and liver.

Animals↗