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N I Iakovleva

Publications and source records attributed to N I Iakovleva.

52 records · Page 3Linked to original sources
PubMed1979

[Effect of tissue hypoxia on the structure of cerebral cortex neurons (light--electron microscopic study)].

An examination of the cerebral cortex of rats exposed to sublethal doses of potassium cyanide has revealed changes in the neurons characteristic of the developing histotoxic hypoxia. The neurons of the large hemisphere cortex showed a pronounced hydropic reaction in their cytoplasm with prevalent involvement of the mitochondria. This form of the pathology was observed irrespectively of the duration of the animals live after the poisoning. In rats which survived for a longer time there appeared hyperchromic neurons the number of which gradually increased. This fact was interpreted as addition of the hypoxic state of the neurons to the cyanide intoxication: this was confirmed by development of signs characteristic of hypoxic hypoxia at this stage. The degree of the changes in the mitochondria was found to correlate with the depth of the impairment of vitally important neuron structures. The data obtained show that the primary morphological changes in the neurons develop in their cytomembranes. The degree of the impairment of the mitochondrial membranes can serve as a criterion of reversibility or irreversibility of the pathological process in the nerve cells.

Animals↗
PubMed1978

[Effect of cytotoxic hypoxia on the metabolism and ultrastructure of cortical synaptosomes and mitochondria].

The study is concerned with morphochemical changes in the metabolism and ultrastructure of the mitochondria and synaptical endings from the cortex of the hemispheres in rats under the influence of cyanide (7mg/kg) following 30 min, 2 hours and 24 hours after its administration. Subfractions of the light and heavy synaptosomes, as well as in the mitochondria of the cell bodies showed changes in the activity of the enzyme systems (cytochromoxidase, K+, Na+-ATPase and Mg2+-ATPase) and disturbances of the ultrastructure of the eliminated organella. After 24 hours the metabolism normalized, which may be explained by a biochemical brain plasticity at the subcellular level under conditions of histotoxic hypoxia.

Adenosine Triphosphatases↗
PubMed1977

[Localization of plasma proteins and beta-lipoproteins in the walls of arteriosclerotic coronary arteries].

Immunofluorescent analysis was used to study the topography of plasma proteins and beta-lipoproteins in the wall of human coronary arteries in cases of atherosclerosis. The dynamics of protein fractions deposits is not uniform in the process of the formation of the disease. Along with the progress of atherosclerosis, the infiltration of proteins, lipoproteins and lipids is increasing. A regular combination of beta-lipoproteins and gamma-globulin localizations was established. The role of the examined components in the wall of the coronary arteries and their participation in the formation of atherosclerotic plaques is discussed.

Adolescent↗