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Biomedical subjects

N I Ivanova

Publications and source records attributed to N I Ivanova.

At least 19 recordsLinked to original sources

[Prevalence of bronchial asthma and allergic rhinitis in the adult population of St. Petersburg].

AIM: To evaluate prevalence of bronchial asthma (BA) and allergic rhinitis (AR) among adult population of St-Petersburg. MATERIAL AND METHODS: Responders to ECRHS and B. Sibbald & E. Rink questionnaires who gave at least one positive answer were examined clinically, functionally and allergologically. A total of 3634 responders aged 16 to 98 years participated in the study. RESULTS: By the answers of the responders prevalence of BA was 7.2%, of AR--9.9%. Such figures were much higher than official statistics. Atopic BA was most frequent among other types--64%. CONCLUSION: It became evident that BA and AR in many cases are diagnosed late or are not recognized at all. This leads to growing number of patients with moderate and severe course of these diseases and deteriorates effectiveness of BA and AR treatment.

Adolescent↗

[Effectiveness of detection of bronchial asthma with two international questionnaires].

AIM: Assessment of two questionnaires (ECRHS and IUATLD) for efficiency in bronchial asthma (BA) detection. MATERIAL AND METHODS: 196 patients aged 16-59 years seeking advice of a doctor for pulmonary or extrapulmonary complaints. All of them have not been previously examined for BA. At first stage of the study the patients filled in ECRHS and IUATLD questionnaires. At the second stage patients who had answered positively as least one question of the above questionnaires underwent clinical, functional and allergological examinations. RESULTS: BA was more frequently detected in patients with chronic bronchopulmonary and allergic diseases. New cases with mild disease predominated. CONCLUSION: Both questionnaires were effective for BA diagnosis but ECRHS showed a number of advantages which make it preferable for epidemiological surveys.

Adolescent↗

[Prevalence of Pseudomonas aeruginosa O serogroups].

The serological typing of 708 P. aeruginosa strains made it possible to determine serogroups in 97.9% of cultures. Serogroups O2 and O6 were the most prevalent (33.8% and 2.5% respectively); serotypes O1, O3 and O11 also occurred rather frequently (about 10%); O4, O7 and O9 were rare (3-8%), serotypes O10 and O12, very rare (less than 1%). The prevalence of P. aeruginosa strains O2 and O6 among the clinical strains was shown over a period of 10 years, serogroup O2 always playing the leading role. In serogroups, the predominance of strains with a definite combination of partial antigen was established; strains with the antigenic structure not described in the International Scheme of the Structure of O-Antigens were detected.

Antigens, Bacterial↗

[Sensitivity to virulent bacteriophages of Pseudomonas aeruginosa strains of different serogroups].

The data on the sensitivity of P. aeruginosa clinical strains to pyocyaneum, a therapeutic and prophylactic bacteriophage preparation, and to individual groups of phages contained in this preparation are presented. Out of 549 P. aeruginosa strains, 16% have proved to be nonlysing cultures. The proportion of phage-sensitive strains prevailed in serogroups 01, 03, 06, 09, while phage-resistant strains prevailed in serogroups 04, 07, 011, as well as among O-nontyped cultures. The expediency of introducing P. aeruginosa strains of different serotypes into the collection of cultures used for the production of pyocyaneum has been shown.

Bacteriolysis↗

[Distribution of phage-resistant Pseudomonas aeruginosa strains].

The sensitivity of a number of P. aeruginosa clinical strains to virulent bacteriophages has been studied. Phage-resistant strains have been found to constitute a considerable proportion among the tested P. aeruginosa strains. The strains under study fall into 19 groups differing in their sensitivity to the bacteriophages used in this investigation. The strains belonging to some groups are phenotypically identical to experimentally obtained P. aeruginosa phage-resistant mutants PAO. The use of bacteriophage mutants has made it possible to demonstrate that in most cases the resistance of P. aeruginosa natural strains to type phi k phages is due to disturbances in their adsorption, whereas their resistance to type phi m and phi mn phages is, seemingly, not linked with disturbances in their capacity for adsorption on the cell membranes of the bacteria.

Adsorption↗

[Comparative evaluation of biological properties of Salmonella typhimurium strains of different origin and genetic nature of resistance to antibiotics].

The results obtained in the comparative study of the biological characteristics of Salmonella typhimurium strains of different origin are presented. The circulation of two biovariants differing in a number of biological characteristics, mainly in their susceptibility to antibiotics, has been shown. R-plasmids, mostly with the markers of resistance to tetracycline and with a molecular weight of 64 Md, have been isolated from "hospital" and "sporadic" strains possessing multiple antibiotic resistance.

Animals↗