Biomedical subjects

N I Kazakova

Publications and source records attributed to N I Kazakova.

3 recordsLinked to original sources

PubMed1999

[Changes in the acid-base status of the synovial fluid in rheumatoid arthritis patients].

AIM: The study of changes in joint fluid (JF) acid-base balance in RA patients to evaluate severity of joint lesions, efficacy of on-going therapy and to predict appearance and persistence of RA remission. MATERIALS AND METHODS: A routine examination and measurements of JF pH of the affected joints and venous blood before and during the treatment were performed in 65 RA patients with articular or articular-visceral forms (46 and 19 patients, respectively). 19 patients were seropositive and 20 seronegative by rheumatoid factor. A group of 17 patients suffering from osteoarthritis deformans with synovitis served control. RESULTS: Inflammation in RA is running with lowering of JF pH in the affected joints and with acidic shift in the acid-base balance manifesting as compensated metabolic acidosis in blood. JF pH of the affected joints inversely correlated with activity of the inflammation. Its changes were more pronounced in RA systemic lesions and in the seropositive variant. CONCLUSION: JF pH may be used for assessment of inflammation activity in RA.

Acid-Base Imbalance↗

PubMed1997

Studies in developmental cytomechanic.

One of the most promising trends in modern developmental and cell biology, recently defined as < >, or < >, is directed towards revealing the role of mechanical stresses, chemomechanical transduction and active stress responses of cells antissues of developing embryos. We review here the results obtained in this field by our research group and compare them with those from other labs. Our studies relate to the buds of hydroid polypes and to amphibian embryos. We describe the space-temporal patterns of mechanical stresses in these species, analyze their morphogenetical role and the tissue responses to the experimental modulations of stress patterns. In hydroid polypes we explore also the molecular events involved in mechanochemical coupling. A model, linking the passive mechanical stresses with the active stress-responses of embryonic tissues is suggested. We consider these investigations as a first approach to a developing embryo as to an < >.

Animals↗

PubMedDate not supplied

[Ultraweak emissions from chicken eggs and embryos: the nonadditive interaction of 2 emitters and stable nonequilibrium].

Ultraweak emission of the optic range from developing, unfertilized, and dead chicken eggs and their components (isolated blastoderm and embryo, entire yolk, white, and shell) was measured at the normal and abnormal temperatures of incubation using a photomultiplier tube. Two sources of ultraweak emission were found: blastoderm and yolk from the fertilized eggs until day 4 of incubation and shell from all eggs, including the unfertilized and dead ones. Emission from the former source was weaker and almost light independent, was recorded only at the temperature of incubation, and had a wavelength of no more than 3000 nm. Emission from the latter source was distinctly light dependent, less temperature dependent, and had a wavelength of 600-800 nm. Ultraweak emission of the entire fertilized eggs was not equal to those of their components: at the early stages of incubation, the internal components of the eggs mostly stimulated ultraweak emission of the shell, while from day 9 of incubation on, they inhibited or absorbed the latter. Absorption and emission of photons by the shell increased as the development proceeded. As compared to the unfertilized and dead eggs, emission from the entire developing egg was characterized by a greater sensitivity to temperature gradients and resistance against small temperature fluctuations in the optimal temperature range. Analysis of the curves of afterillumination decrement of ultraweak emission suggests a significant coherence of emission from the entire developing egg and whole shell, rather than from the unfertilized and dead eggs and shell fragments.

Animals↗