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Biomedical subjects

N I Kochetygov

Publications and source records attributed to N I Kochetygov.

At least 19 recordsLinked to original sources
PubMed1998

Side reaction caused by the perfluorocarbon emulsions in intravenous infusion to experimental animals.

The perfluorocarbon (PFC) emulsions are infusion gas-transporting media and are usually called the artificial blood. However anaphylactoid reaction were observed during intravenous infusion of PFC emulsions. The cause of side reactions is the activation of the complement system. An indirect sign of the intravascular activation of the complement is the neutropenic effect in the peripheric blood. Taking into consideration the phenomen, the method of evaluation of anaphylactoid reaction caused by PFC emulsions has been elaborated using the neutropenic index. We evaluated the biocompatibility of 26 PFC emulsions of different composition in intravenous infusion to rabbits using this index. Emulsions evoked reactions of different extent. Some emulsions did not cause the neutropenic effect at all. Results of this work allow to reach conclusion, that influence of PFC emulsions on the complement system is explained not only by emulsifying agent proxanol: the stability of emulsions in the vascular bed and in the period of storage in frozen state is of great importance as well.

Akathisia, Drug-Induced↗
PubMed1996

Study of therapeutic efficiency of new blood substitutes in experimental hemorrhagic shock.

In experiments on dogs, which were anesthetized and underwent hemorragic shock, the hemodynamics, oxygen transport and acid-base status were studied. Cardiac function was studied using ultrasound equipment. It was established that administration of Volekam and Polyoxidin corrects hypovolemia with subsequent restoration of arterial pressure in the aorta and cardiac cavities and increase in the myocard contractility and cardiac output. Comparative analysis has shown that Polyoxidin exerts a more prolonged action than Volekam. In addition, Polyoxidin decreases the blood and plasma viscosity, lowers the blood cells aggregation which promotes the restoration of peripheral circulation. The efficiency of Volekam and Polyoxidin is not inferior to that of the well known blood substitute Polyglukin (dextran group) and, in respect of some parameters, is even superior to that of the latter.

Animals↗
PubMed1996

[Modezhel' erythrocyte preservative as an experimental and clinical blood substitute].

The model of hemorrhagic shock in dogs was used to show that the infusion of "Modegel" normalizes the arterial pressure, substantially increases the minute volume of blood circulation. The circulating blood volume rises up to the initial level at the expense of the increased plasma volume. "Modegel" gives stable correction of the acid-base balance of blood. In clinic "Modegel" was used for filling the apparatus of artificial circulation and compared with the blood substitute "Gelatinol" for operations on the open heart. Examinations of the patients have shown that "Modegel" unlike "Gelatinol" does not induce hypercalcemia and hyperosmolarity of plasma while moderate hyperoncoticity of plasma is responsible for the circulating blood volume and favorable conditions for microcirculation.

Animals↗
PubMed1993

[Infusion therapy of experimental hemorrhagic shock using the antihypoxic drug oliphen].

The authors studied the potential of an antihypoxic drug oliphen in raising the efficacy of hemorrhagic shock treatment with sodium chloride isotonic solution. The severity of the shock and the efficacy of treatment were evaluated by parameters of central hemodynamics, microcirculation, oxygen regimen and acid-base condition. Dog and white rat experiments showed that the addition of oliphen to solution treatment produced better results than sodium chloride solution alone.

Animals↗
PubMed1991

[Study of chemically modified hemoglobin as an artificial oxygen carrier in the model of hemorrhagic shock in dogs].

Hemodynamic and gas-transporting properties of the chemically modified hemoglobin solution have been studied on the model of hemorrhagic shock in dog. It has been shown that the polymerized hemoglobin solution exerts the hemodynamic action just as the plasma substitute "polyglucin" does. However, in contrast to the latter, polyhemoglobin circulating in the vascular bed for a prolonged period of time increases the blood oxygen capacity and oxygen delivery to tissues with the resultant increase in body total oxygen taking-up.

Animals↗
PubMed1990

[Activation of the complement system of plasma and the changes in various parameters of homeostasis in rats after intravenous administration of emulsion of organoperfluorine compounds].

Anticomplementary activity of emulsion based on the organoperfluorine compounds (PFC) perfluorodecalin and perfluorotripropylamine (7:3) has been shown in vitro. A temporary reduction of the neutrophil number up to 25% of the initial level was recorded 5 min after intravenous plethoric administration of 1.0 ml of this emulsion to rats. A drop in the arterial pressure and blood minute volume was observed in half of the animals, 30 and 60 min later impairment of the body oxygen regimen resulting in tissue hypoxia was recorded in all the rats. It has been suggested that the disorders observed in the animals are caused by the action of varying mediators produced due to the intravascular activation of the complement by PFC.

Animals↗
PubMed1989

[Experimental study of hemodynamics and oxygen regimen in the body during replacement of massive blood loss with a suspension of erythrocytes in a solution of modified deionized gelatin].

In experiments on dogs with acute massive hemorrhage the effectiveness has been studied of red blood cell suspension in glucose-saline solution N 8 prepared in the Central Research Institute of Hematology and Blood Transfusion, and in a preservative based on gelatin developed in the Leningrad Research Institute of Hematology and Blood Transfusion. The advantage of the colloid preservative has been proved by the parameters of macro- and microdynamics of the blood, oxygen-basic state, oxygen budget and rheologic properties of the blood.

Animals↗
PubMed1989

[Characteristics of the effect of various erythrocyte-containing media on central hemodynamics, microcirculation and oxygen consumption during the treatment of massive hemorrhage].

Experiments in 30 rats have shown that transfusion of autologous erythrocytes suspended in the modified deionized gelatin exerts a more pronounced positive effect upon central hemodynamics, microcirculation and oxygen regimen as compared with transfusion of the whole autologous blood and erythrocyte mass.

Animals↗
PubMed1988

[Erythrocyte-containing media in programs of infusion-transfusion therapy in massive blood loss].

The article presents data on medical effects of the whole glucose-citrated blood, erythrocyte mass and erythrocyte suspension in the solution of modified gelatine used in the scheme of the infusion-transfusion therapy for massive blood loss in experiment. The advantages of erythrocyte suspension in the gelatine solution was confirmed by data on systemic hemodynamics, oxygen regimen and acid-base state of the organism.

Animals↗
PubMed1985

[Systemic hemodynamics and regional microcirculation in diffuse peritonitis].

A complex study of the central and peripheral hemocirculation in 134 patients and direct control of the microcirculation bed by the method of contact microscopy in 15 experiments in dogs were used in order to study the character of disturbances of microcirculation depending on the phase of diffuse peritonitis. It was established that a reactive of peritonitis is characterized by an active spasm of microvessels changed by their paralytic dilatation followed by stasis, aggregation of formed elements, edema and infiltration of tissues.

Acute Disease↗
PubMed1984

[Effect of lysosomal enzymes on myocardial electrical and contractile activity in burn shock].

Marked depression of the amplitude of isometric contractions of myocardial preparations, which was induced by lysosomal enzymes from the liver of control animals, was demonstrated in isolated rabbit papillary muscles. The decrease of contractility was not accompanied by remarkable changes in the amplitude or in the duration of intracellular action potentials. The negative inotropic action of lysosomal enzymes was similar to that of blood plasma of the burnt animals. Based on the appearance and subsequent activation of lysosomal enzymes in blood of the animals by the 20th to 60th min after thermal injury it is suggested that lysosomal enzymes might be one of factors that depress myocardial contractility in burn shock.

Action Potentials↗