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N I Krutilina

Publications and source records attributed to N I Krutilina.

4 recordsLinked to original sources
PubMed2005

[Application of peptide bioregulator in complex treatment of elderly cancer patients].

Improvement of elderly cancer patients' treatment is an acute issue in oncology. The results of stage III rectal and colon cancer complex treatment are far from being satisfactory in this category of patients. In this connection the search for new adjuvant drugs supplementing radio and chemotherapy is urgent. The article describes pioneer experience in complex radical treatment of elderly cancer patients with immunomodulator Vilon included into the scheme of treatment. The obtained preliminary results of investigation suggest recommendation of Vilon application to increase 2-year survival of patients, prevention of post-operative complications, remote complications, recurrences and tumor dissemination, as well as the improvement of the quality of life after employment of aggressive methods of treatment.

Adult↗
PubMed1993

[A comparative study of the reactions of the peripheral blood neutrophils from donors and from lymphogranulomatosis patients to arachidonate stimulation of the cells].

Arachidonate-induced aggregation and generalization of active oxygen forms (OAF) by peripheral blood neutrophils in donors were studied in donors and Hodgkin's disease patients. Leukocytes of the latter had incomplete ability to produce AOF in response to cell stimulation with arachidonic acid. The study of arachidonate-induced aggregation of neutrophils indicated no differences in the speed of the process in the patients and donors. AOF catchers did not act on the rate of leukocyte aggregation in the patients though accelerated the process in the donors. It is inferred that Hodgkin's disease is associated with dysfunction of oxygen activation by neutrophils. The findings suggest that defects in leukocytes ability to activate oxygen in Hodgkin's disease may entail deranged regulation of other processes essential for functional activity of polymorphonuclear leukocytes.

Adult↗
PubMed1991

Enterosorption in oncotherapy.

Patients with lymphogranulomatosis undergoing radiotherapy according to the radical scheme were treated with fibrous carbon enterosorbent VESTA in tablets for 14 days (group I, 23 patients) from the moment of leukopenia development (lower then 2.2 x 10(9)/l) or were traditionally treated using parenteral administration of hemostimulants, hemosubstitutes and detoxicants (group II, 23 patients). After 14 days leukopenia was cured in 18 patients of group I (78%) and in 11 patients of group II (48%), with an average number of leukocytes in the patients of groups I and II growing by 2 and 1.6 times, respectively. The administration of enterosorbents enabled interruptions in radiotherapy caused by the development of leukopenia and the deterioration of health status to be greatly shortened and the requirements in expensive transfusion media to be sharply reduced.

Adult↗