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N I Kustova

Publications and source records attributed to N I Kustova.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Individual immunogenetic characterization of patients with diffuse toxic goiter and autoimmune thyroiditis].

Statusmetry as a variant of a method of collective image recognition was used for evaluation of integral immunogenetic characterization of patients with toxic goiter (TG) and autoimmune thyroiditis (AT). Typing of 40 HLA antigens, class I, was performed in 114 TG patients, 106 AT patients and 500 healthy subjects, however this analysis employed the frequency of expression of 26 most informative specificities (9 alleles of locus A and 17 alleles of locus B of the HLA system). Functional models and decision rules to recognize TG, AT, remission and recurrence (decompensation) of TG were worked out. Recognition probability by the zero threshold was 68.4-78.3%. It was proposed that individual immunogenetic statusmetry should be used as part of diagnostic methods for TG and AT, their differential diagnosis, and a long-term prognosis of medicinal recurrence (decompensation) of TG.

Alleles↗
PubMedDate not supplied

[The HLA system in diffuse toxic goiter].

The paper is concerned with the determination of class I antigens of the HLA system in 104 patients with diffuse toxic goiter and in 643 donors. A study was made of the distribution of antigens, haplotypes and phenotypes of the HLA system. An increase in the frequency of antigens A28 and B8, haplotype [correction of haploptin] A1-B8 and phenotype B7, B8 and a decrease in the frequency of antigens B13, B17 and Cw4 were revealed. Immunogenetic indices showed no correlation with clinical, hormonal and immunological manifestations of the disease, neither did they influence the therapeutic prognosis of diffuse toxic goiter. A great genetic difference was revealed between patients with a relapse (decompensation) and those at remission.

Adolescent↗