Biomedical subjects
Publications and source records attributed to N I Levchenko.
Toxic properties of acetopropyl alcohol were studied. Symptoms of CNS damages predominated in toxicodynamics. A maximal single concentration is 0.2 mg/m3 (4th class of danger).
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The authors compare the efficacies of methods for assessing osmolality (OSM) and analysis of medium molecules (MM) in the prediction of the post-stroke period course in the first 7 days from the stroke onset. Prognostically unfavorable MM and OSM values were found, predicting the possible lethal outcome. On the whole the MM index was found 1.7 times more sensitive for this prediction than the OSM index; the possibility of predicting a lethal outcome from the MM value within the first 24 hrs was 3 times higher and within the first 48 hrs 4 times higher vs. the OSM value.
Critical conditions that develop because of hypoxia of different genesis are accompanied by endogenous intoxication induced to a considerable degree by the appearance in the blood of an excess amount of medium-sized molecules (MSM). An appreciable increase of the content of MSM was demonstrated since the very first days after the brain stroke as a result of examining 100 patients who suffered brain stroke, including 83 patients during the first week of the disease and 17 patients of the reference group with a history of acute impairment of cerebral circulation which had occurred over a month before. A reverse correlation was established between the level of endogenous intoxication and the clinical status of the patients which could be observed every day during the acute disease phase. The critical level of MSM was determined in the patients' blood plasma. In the majority of cases, the attainment of the above level resulted in a lethal outcome irrespective of the pattern of acute impairment of cerebral circulation. The data obtained make it possible to recommend using the level of MSM as one of the simple and rapid quantitative methods for assessment of the patients' status gravity and monitoring of persons with acute impairment of cerebral circulation.
Patients with severe Guillain-Barre syndrome were entered into 2 groups: group I was treated with hormones alone, group II with hormones plus plasmapheresis. The results were not significantly different. In view of recognized effectiveness of plasmapheresis for treatment of the syndrome, corticosteroid addition is inappropriate.
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The liver monooxygenase system activity was studied in 100 workers by measuring the half-life period of antipyrine and its clearance from saliva. The examined contacted with lead (22 cases), vanadium (11 cases), manganese (14 cases), fluorine (53 cases). In average, in a half of those examined the antipyrine half-life period shortened to less than 10 hours. The contributors hold that the new technique of functional examination of the liver can hardly be applied to for diagnosing toxic affections of the liver. Anyhow the technique demonstrates that metals contribute to liver monooxygenase, which, in case of a combined effect, can increase metabolism of other compounds.
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The authors analyze the development of optic disc congestion in patients with acute polyradiculoneuritis. Basing on an analysis of the brain hydrodynamics examined with the aid of the subarachnoidal infusion test, the authors come to the conclusion that the main pathogenetic factor responsible for the development of intracranial hypertension and optic disc congestion in the patients examined is the syndrome of the decreased cerebrospinal fluid absorption. It is emphasized that basic to the treatment of intracranial hypertension and optic disc edema during the disease in question should be measures aimed at the improved drainage of the cerebrospinal fluid to the cerebral venous system.
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