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Biomedical subjects

N I Rybakov

Publications and source records attributed to N I Rybakov.

At least 19 recordsLinked to original sources
PubMed1980

[Immune status of patients with rectal cancer].

Studies on the status of immune response in patients with rectal cancer have shown significant changes in the number of immuno-competent cells prior to the treatment, which were still more pronounced during and following the radiation therapy. The degree of immune suppression is dependent on the tumor spread, patient's age and a radiation dosage.

Adult↗
PubMed1979

[Oxygen effect in the therapy of lung cancer].

Nine lung cancer patients were subjected preoperatively to radiotherapy under hypoxia with inhaling of GHM-10 (gas hypoxic mixture). The patients were followed up during 7--12 months. The results obtained evidence the rationality of further studies in this direction, that is of special importance due to introducing of reconstructive--plastic operations on the trachea and bronchi into oncological practice. Thus, there will be a possibility to preserve, in some cases, a porton of the lung. Since the functional status of the lung after surgical and radiation treatment is of primary importance for the duration of patients' survival, the lung tissue protection from side-effects of radiation in irradiating lung tumors may offer good perspectives.

Adenocarcinoma↗
PubMed1976

[Study of the virustatic action of rimantadine based on a phage-bacterium model].

The action of rimantadin on the lambda phages was studied. The maximal inhibitory effect on the compound was observed on the 1st-6th minutes after the infection. There was no such effect on the T-4 and lambda phage replication. According to the data of incorporation of the radioactive precursors into the phage DNA, RNA, and proteins, and the manifestation of the rimantadin action on phage replication it was supposed that the inhibitory effect of rimantadin was determined by its influence on the RNA-polymerases, preponderantly on the phage RNA-polymerase.

Adamantane↗
PubMed1976

[Effect of the combined action of rimantadin and dimethyl sulfoxide on phage reproduction].

Separate and combined action of Dimethylsulfoxid (DMSO) and Rimantadin on the reproduction of phages T--3, T--4, T--7 and lambda was studied. The maximum activation of reproduction of phages T--3 and T--7 by DMSO was observed for 6 minutes of latent period. At the same time this compound did not render the action on reproduction phages T--4 and, because they utilize cell RNA-polimerase. It was shown that DMSO stimulated the synthesis of T--3 phage DNA by action on T--3 phage RNA-polymerase. Combined application of both DMSO and Rimantadin eleminated in some degree its reciprocal effect on T--3 phage macromoelecules synthesis and complet eliminated inhibitory action of Rimantidin on infective phage T--3 production.

Adamantane↗
PubMed1971

Experiments with micro-organisms and human cell cultures in the Zond 5 and Zond 7 flights.

Lysogenic strains of Escherichia coli were exposed to space conditions aboard the flight of Zond 5 and Zond 7. Space flight factors appeared to affect the state of episome systems of bacteria, as judged by data obtained with F-Lac+ donor cells which also carried genetic markers for threonine and leucine. Observations on phage induction are discussed and compared with results obtained aboard Biosatellite 2. A number of monolayer cultures of human cells (HeLa cells, fibroblasts, and A-1 cells) were repeatedly exposed to the space environment. In one instance, HeLa 19 cells increased in size after exposure to space conditions, a change which appeared to be genetically stable. HeLa 19 cells which were carried on six separate space flights showed a higher viability than corresponding cultures which were exposed only once aboard Zond 5.

Cell Physiological Phenomena↗